Elucidation of extracellular vesicles derived from the atherosclerotic microenvironment

• Project/Area Number: 25K12065
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: 栗山 直也 旭川医科大学, 医学部, 助教 (50837911)
• Co-Investigator(Kenkyū-buntansha): 菊地 信介 旭川医科大学, 医学部, 准教授 (80596297)
• Project Period (FY): 2025-04-01 – 2030-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2029: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2028: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2027: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2026: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2025: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 動脈硬化 / 細胞外小胞

Outline of Research at the Start

糖尿病増加を背景に深刻化する下肢末梢動脈疾患(LEAD)の動脈硬化微小環境において、細胞外小胞(EV)が果たす役割を解析する。in vitroの系で患者由来病変EVの機能評価を行った後、その機能を示すmiRNAを同定するためmiRNA網羅的解析を実施し、動脈硬化進展の新規メカニズム解明とEVを用いた治療法開発を目指す。