Evaluation of disease activity and inhibition of ossification progression using exosomal anti-membrane protein antibodies derived from ossification of spinal ligaments

• Project/Area Number: 25K12454
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: University of Fukui
• Principal Investigator: 中嶋 秀明 福井大学, 学術研究院医学系部門, 准教授 (10397276)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2026: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脊柱靱帯骨化症 / エクソソーム / 疾患活動性評価 / 骨化抑制 / バイオマーカー

Outline of Research at the Start

1. 脊柱骨化靱帯由来エクソソームを用いて、骨化の発生・進展を規定する候補タンパクを解析
2. 骨化靱帯由来エクソソーム膜タンパクのバイオマーカー・治療ターゲットとしての可能性を検証
3. 抗異所性骨化・抗炎症効果をもつ候補薬剤の骨化抑制効果および副作用発現を検証