Establishment of a Foundation for Methods to Inhibit Biofilm Formation and Novel Therapeutic Strategies for Refractory Urinary Tract Infections

• Project/Area Number: 25K12612
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Okayama University
• Principal Investigator: 渡邉 豊彦 岡山大学, ヘルスシステム統合科学学域, 教授 (30432644)
• Co-Investigator(Kenkyū-buntansha): 定平 卓也 岡山大学, 医療開発領域, 研究准教授 (20733322)
• Project Period (FY): 2025-04-01 – 2030-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2029: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2028: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 尿路感染症 / バイオフィルム

Outline of Research at the Start

反復性膀胱炎患者の膣と尿から分離された尿路病原性大腸菌（UPEC）株を用いて、それらのバイオフィルム形成に寄与する責任因子の同定並びに、バイオフィルム形成抑制法の基盤構築を行う。