| Project/Area Number |
25K12779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Fujita Health University |
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Principal Investigator |
吉岡 哲志 藤田医科大学, 医学部, 准教授 (20648539)
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| Co-Investigator(Kenkyū-buntansha) |
山原 康平 藤田医科大学, 医学部, 講師 (00909153)
楯谷 智子 京都先端科学大学, 健康医療学部, 教授 (10512311)
楯谷 一郎 藤田医科大学, 医学部, 教授 (20526363)
大島 猛史 日本大学, 医学部, 教授 (40241608)
岡野 高之 藤田医科大学, 医学部, 教授 (60642931)
池田 裕隆 藤田医科大学, 医学部, 講師 (70750959)
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| Project Period (FY) |
2025-04-01 – 2028-03-31
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| Project Status |
Granted (Fiscal Year 2025)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2027: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 耳管開放症 / 甲状腺眼症 / テプロツムマブ / IGF-1 / 耳管 |
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| Outline of Research at the Start |
Atrophy of the Eustachian tube(ET) surrounding tissues is implicated in the development of Patulous ET(PET). A high incidence of PET was reported in users of the IGF-1 receptor inhibitor (teprotumumab), a treatment for dysthyroid orbitopathy. This suggests the presence of IGF-1 receptors in this area. We will use imaging and animal studies to clarify the morphological and functional characteristics of Eustachian tube opacities and the role of IGF-1 in the maintenance of the ET surrounding tissues. In addition, we will examine the pathogenesis and treatment of PET.
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