Investigation of the molecular mechanism causing cell death to evaluate the high hydrostatic pressure safe devitalization thresholds

• Project/Area Number: 25K12906
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Kyoto University
• Principal Investigator: Munisso MariaChiara 京都大学, 医学研究科, 特定研究員 (50616084)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2026: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: HHP / cell death pathway

Outline of Research at the Start

I will clarify the main cell death pathways and I will highlight the role of fundamental factors which may end ups in cancer cell resistance to HHP therapy. This study will include 4 phases: identification of the death molecular mechanisms using (1) cell suspensions, (2) cell sheets, and (3) spheroids and cultured dermis and, then (4) the comparative analysis of 3 models results of HHP and LN treatments.