Impact of Age-Related Changes in Osteocyte Network on Bone Quality: Tissue Level 3D Imaging Using a Novel Light Sheet Microscope

Research Project

Project/Area Number	25K13101
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57050:Prosthodontics-related
Research Institution	Niigata University
Principal Investigator	Rosales Marcelo 新潟大学, 医歯学系, 助教 (20727127)
Co-Investigator(Kenkyū-buntansha)	加来賢新潟大学, 医歯学系, 准教授 (30547542)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2027: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	light-sheet microscope / bone metabolism / Osteocyte network / bone regeneration
Outline of Research at the Start	This study aims to 1. Optimize 3D imaging for characterizing age-related changes in the osteocyte network. 2. characterize the age-related changes in bone morphology and mechanical properties. 3. Assess the relationship between changes in the osteocyte network on bone quality.