The Role of Cancer-Associated Adipocytes in the Tumor Microenvironment of Cervical Lymph Node Metastases in Oral Cancer

Research Project

Project/Area Number	25K13209
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Ehime University
Principal Investigator	栗林恭子愛媛大学, 医学部附属病院, 助教(病院教員) (60579952)
Co-Investigator(Kenkyū-buntansha)	栗林伸行愛媛大学, 医学系研究科, 助教 (80617332) 中城公一愛媛大学, 医学系研究科, 准教授 (90314880)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2026: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	癌関連脂肪細胞 / 口腔扁平上皮癌 / 頸部リンパ節転移
Outline of Research at the Start	口腔扁平上皮癌のリンパ節転移節外進展における癌関連脂肪細胞の存在についてシングルセル解析を用いて分子レベルで明らかにし、癌関連脂肪細胞が口腔癌細胞におよぼす影響を in vitro および in vivo を用いて明らかにする。