Nanoplastic-Induced Neurotoxicity: Exploring Microglia's Role in Cardiovascular Regulation Centers

• Project/Area Number: 25K14899
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: International Christian University
• Principal Investigator: グホ サビン 国際基督教大学, 教養学部, 教授 (30453179)
• Co-Investigator(Kenkyū-buntansha): 和気 秀文 順天堂大学, スポーツ健康科学部, 教授 (50274957)
• Project Period (FY): 2025-04-01 – 2030-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2029: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2028: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2025: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: microglia / nanoplastic / neurotoxicity / cardiovascular centers / gene expression

Outline of Research at the Start

Whether and how nanoplastics (NPs) cause brain damage remains unclear. This project investigates microglia (MG) cellular and molecular responses to NP exposure and resulting neurotoxicity in vitro and in vivo. It also explores strategies to mitigate MG response to NPs and related neurotoxicity.