Rapamycin-loaded pH-responsive micelles with dual functions for anti-cancer and anti-aging effects

• Project/Area Number: 25K15906
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
• Principal Investigator: Mohamed Aziz・Awaad・Aziz 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (50978286)
• Co-Investigator(Kenkyū-buntansha): 三浦 裕 東京科学大学, 総合研究院, 准教授 (40557980) ; 本田 雄士 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (90907742)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: polymeric micelle / zwitterionic / immunogenicity / nanocarrier / rapamycin

Outline of Research at the Start

The main problem for aged patients who are suffering from idiopathic pulmonary fibrosis (IPF) as an anti-aging disease is cancer associated lung fibrosis. Hence, smart polymeric micelles loaded with rapamycin will be synthesized for treatment of cancer especially that associated with fibrosis