Integrable Nanoliter-Scale Device for Electrophoretic Microchip Analysis of Single-Cell Glycome

• Project/Area Number: 25K18061
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 34020:Analytical chemistry-related
• Research Institution: Kyushu University
• Principal Investigator: LIU CHENCHEN 九州大学, 理学研究院, 助教 (50963211)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2025: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: Trace sample / Single cell glycome / Online purification / Nano-liter reactor / Electrophoresis

Outline of Research at the Start

We propose a method for single-cell glycan analysis. A nanoliter-scale device will be developed for sample preparation, along with a customized laser-induced fluorescence detector designed for highly sensitive glycan sensing. This project will lead to a novel approach to trace sample analysis.