Establishment of advanced NHPs synthetic cardiovascular embryo models

• Project/Area Number: 25K18474
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44020:Developmental biology-related
• Research Institution: Kyoto University
• Principal Investigator: NASRI Amel・Setti 京都大学, 高等研究院, 特定研究員 (41002091)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2026: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: iPSCs / heart

Outline of Research at the Start

We aim to recreate primate cardiovascular development in vitro using NHP cells to model fetal heart failure and embryonic diseases. By identifying species-specific markers with scRNA-seq, we enhance our understanding of cardiovascular morphogenesis and evolution. This ethically designed model opens new avenues for regenerative medicine, disease modelling, and complex synthetic embryo systems.