Identifying shared theraputic targets for mitochondrial diseases using comprehensive single cell transcriptomics analysis.

• Project/Area Number: 25K18734
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49010:Pathological biochemistry-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Qaqorh Tasneem 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー (40995974)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2026: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: Mitochondrial disease

Outline of Research at the Start

Mitochondrial diseases (MDs) are currently incurable. We do not yet understanding their underlying molecular mechanisms and early triggers for tissue dysfunction. This study aims to find shared targets for therapies in all tissues affected by MDs using new single-cell transcriptomics technology.