Clarification of MDP1 stress mediation mechanism for BCG survival in macrophages

Research Project

Project/Area Number	25K18794
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 49050:Bacteriology-related
Research Institution	Niigata University
Principal Investigator	Shaban AminaKaboso 新潟大学, 医歯学系, 助教 (50996874)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2027: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2026: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2025: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	Tuberculosis / BCG / Intracellular survival / hupB / Gene regulation
Outline of Research at the Start	MDP1 protein is key for mycobacterial stress survival. We previously showed it regulates gene expression for BCG survival in growth medium. Now we probe MDP1's mechanism for BCG survival in macrophages using dual RNA-seq and ChIP-seq. Results will inform new TB drug targets and vaccine development.