| Project/Area Number |
25K18800
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49050:Bacteriology-related
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| Research Institution | The University of Osaka |
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Principal Investigator |
Pratama Andre 大阪大学, 微生物病研究所, 特任助教(常勤) (30972319)
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| Project Period (FY) |
2025-04-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2025)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2026: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Vibrio parahaemolyticus / T3SS / gene regulation / virulence / sRNA |
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| Outline of Research at the Start |
The pathogenic bacterium Vibrio parahaemolyticus causes acute gastroenteritis in humans by deploying its Type III Secretion System 2, encoded on pathogenicity island and activated by intestinal signals such as temperature, salinity, and bile salts. Our previous study found that these same signals also induce the expression of novel sRNA, suggesting a potential role in virulence regulation. This study aims to investigate the biogenesis of the sRNA, identify its targets, and elucidate the mechanism of sRNA-mediated regulation in V. parahaemolyticus pathogenicity.
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