Organoid study to identify the molecular mechanisms of diffuse-type gastric cancer development

• Project/Area Number: 25K18872
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kanazawa University
• Principal Investigator: WANG DONG 金沢大学, ナノ生命科学研究所, 特任助教 (20842983)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2026: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: gastric cancer

Outline of Research at the Start

To explore the role and mechanisms of Cdh1 and Pigr mutations in DGC development, we will use bio functional studies to reveal their functions and use RNA-seq etc. to understand the regulation mechanism. Ultimately, we will identify unique physical characteristics of DGC by SICM for early diagnosis.