Quantitative analysis of the G1/S transition mechanism underlying ErbB2 signaling in the process of breast cancer proliferation

Research Project

Project/Area Number	25K18877
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 50010:Tumor biology-related
Research Institution	The University of Osaka
Principal Investigator	市川彩花大阪大学, 蛋白質研究所, 助教 (70869106)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2027: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	乳がん / 細胞周期 / ErbB2
Outline of Research at the Start	本研究では、乳がんの腫瘍マーカーに含まれるErbB2受容体と細胞周期の開始に重要なG1期からS期への遷移機構との関係を分子レベルで定量的に評価する。そして、ErbB2受容体の発現状態の違いがどのように細胞周期分子の応答性を変化させ、ひいては細胞周期阻害剤への感受性、増殖動態の変化に繋がるのか、そのメカニズム解明を目指す。