A Novel Techniques for In Vivo Neuronal Imaging in the Mouse Brain

• Project/Area Number: 25K18949
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51010:Basic brain sciences-related
• Research Institution: Niigata University
• Principal Investigator: 劉 シンイ 新潟大学, 脳研究所, 助教 (40813928)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2025: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: clearing / mouse brain

Outline of Research at the Start

This research develops "SeeThrough," a non-invasive skull clearing technique using a refractive index matching solution for enhanced, high-resolution brain imaging. It enables detailed, longitudinal studies of neuronal structure and function without skull removal.