Comprehensive Genomic Analysis for Pathophysiological Insights and Risk Stratification in Tachycardia-Induced Cardiomyopathy

Research Project

Project/Area Number	25K19360
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 53020:Cardiology-related
Research Institution	Hiroshima University
Principal Investigator	古谷元樹広島大学, 医系科学研究科(医), 特任助教 (71001294)
Project Period (FY)	2025-04-01 – 2030-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2029: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2028: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	頻脈誘発性心筋症 / SNP / Whole genome sequence / RNA-sequence / risk stratification
Outline of Research at the Start	頻脈誘発性心筋症 (Tachycardia induced cardiomyopathy:TIC)に対して、網羅的遺伝子解析(Genome-wide　association study、ミトコンドリアDNA解析、Whole genome sequence(解析)を行ない、TIC発症のメカニズムを解明し、TIC発症のリスク評価に有用なバイオマーカーの同定を目的とする。動物モデルを用いた機能解析を行うとともに、得られた遺伝子学的情報と臨床情報との関連を明らかにし機械学習を駆使して、TIC層別化モデルの構築も行い、このモデルが不整脈による心不全の予測にも有用かどうか検討する。