Extravasation control of monocyte from PDGFRa-embryonic lineage and its unique impacts on skin physiology

• Project/Area Number: 25K19529
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: The University of Osaka
• Principal Investigator: Li YuTung 大阪大学, 大学院医学系研究科, 寄附講座講師 (80933407)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2025: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: macrophage / monocyte / cell fate / extravasation

Outline of Research at the Start

Optimal extravasation control of leukocytes is essential to drive effective immunity. This study aims to understand controlling factors and consequences a novel trafficking behaviour of monocytes to inflamed skin. The finding is expected to aid development of new therapeutics for skin inflammation.