Gut microbiota-mediated tissue protection by memory formation in HSCs

• Project/Area Number: 25K19581
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kumamoto University
• Principal Investigator: HO Pui・Yu 熊本大学, 国際先端医学研究機構, 特定研究員(国際先端医学研究拠点施設) (40888385)
• Project Period (FY): 2025-04-01 – 2030-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2029: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2028: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: Hematopoietic stem cell / Gut microbiota / Immune memory

Outline of Research at the Start

We show that Bacteroides pre-stimulation enhances HSC resilience and protects against immune-driven tissue damage. This effect stems from Bac-stimulated HSCs. We aim to identify the microbial components and mechanisms involved to inform immune-boosting therapies.