| Project/Area Number |
25K19643
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54030:Infectious disease medicine-related
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| Research Institution | Japan Institute for Health Security |
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Principal Investigator |
アザム アアハエルマン 国立健康危機管理研究機構, 治療薬・ワクチン開発研究センター, 研究員 (80852780)
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| Project Period (FY) |
2025-04-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2025)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2026: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2025: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Bacteriophage / Reverse Transcriptase / Defense system / Repeat protein |
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| Outline of Research at the Start |
Prokaryotic immune systems have led to transformative technologies such as monoclonal antibodies, RNAi, and CRISPR-Cas9. Now, a newly discovered reverse transcriptase-related defense system promises to be the next breakthrough. Certain RTs have been reported to synthesize near-infinite repeat cDNA upon phage infection, producing toxic proteins that inhibit phage proliferation. However, its activation and regulatory mechanisms remain unclear. This study aims to elucidate such RT mechanisms and develop novel gene and protein synthesis technologies.
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