Phytic Acid (Inositol Hexaphosphate): A Next-Generation Biomaterial with Antimicrobial, Anti-inflammatory, and Remineralization Properties for Dental Pulp Regeneration

Research Project

Project/Area Number	25K20277
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 57030:Conservative dentistry-related
Research Institution	Tohoku University
Principal Investigator	MOESANDARKYAW 東北大学, 歯学研究科, 助教 (80996405)
Project Period (FY)	2025-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2026: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	Phytic acid / IP6 / Pulp regeneration / Remineralization / Pulpitis
Outline of Research at the Start	Phytic acid (IP6) has a high phosphate content and is able to promote hydroxyapatite nucleation. It also reduces inflammation through ROS scavenging and immunomodulation, and offers biocompatible, antibacterial properties, making it a promising candidate for pulp regeneration and remineralization.