Analysis of the expression dynamics of intraoral trigeminal ganglion calcitonin gene-related peptide in pain

• Project/Area Number: 25K20387
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: The Nippon Dental University
• Principal Investigator: 猪俣 徹 日本歯科大学, 生命歯学部, 客員准教授 (60868008)
• Project Period (FY): 2025-04-01 – 2029-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2028: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 猪俣

Outline of Research at the Start

口腔内乾燥の原因となる唾液腺の萎縮、数の減少、腺の消失、粘膜下組織の血管減少に対する改善の可能性やCGRPを皮下投与すると創傷治癒が早まる効果などCGRPの未知なる可能性を分子生物学的レベルから解明する。