Decoding the RNA-Bound Proteome as a Novel Bone Resorption Target during Orthodontic Tooth Movement

• Project/Area Number: 25K20447
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: MARAHLEH ASEEL・MAHMOUD・SULEIMAN 東北大学, 学際科学フロンティア研究所, 助教 (10963100)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: OTM / RNA binding Proteins / Osteocyte / Mechanical Loading / Bone remodelling

Outline of Research at the Start

Bone remodeling during orthodontic tooth movement is governed by molecular mechanisms. We will study how RNA binding proteins (RBPs) control bone remodeling in response to mechanical stress in order to identify top RBP targets that can serve as anabolic agents for bone in diseases such as osteoporosis. And to identify RBPs that can targeted to halt bone resorption that accompanies osteolytic (done destruction) diseases.