Effects of FFAR4 Activation on GLP-1 Expression and Bone Metabolism in an Obesity mouse model

• Project/Area Number: 25K20448
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: MA JINGHAN 東北大学, 歯学研究科, 助教 (51000880)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2025: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: GPCR / osteocyte / obesity / OTM

Outline of Research at the Start

It is expected that DHA intake can reduce inflammation-induced bone resorption. However, the relationship between FFAR4 and osteocytes, as well as the role of FFAR4 in bone metabolic disorders remains unclear. Therefore, this study could find out the potential connections between FFAR4 signaling, osteocyte regulation, and obesity-induced bone resorption.