Nanothermometer endoscopy for temperature sensing in tumor tissue

• Project/Area Number: 25K21569
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Hokkaido University
• Principal Investigator: TAEMAITREE FARSAI 北海道大学, 電子科学研究所, 助教 (30962485)
• Project Period (FY): 2025-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2025: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: Nanothermometer / Nanoparticle / Nanoendoscopy / Hyperthermia / Tumor

Outline of Research at the Start

Localized hyperthermia via heat-generating nanoparticles is a promising approach to cancer therapy. However, its clinical potential is limited as there is a serious lack of standard temperature monitoring techniques with adequate resolution to probe nanoscale temperature changes. To address this challenge, we developed a nanothermometer endoscope based on luminescent lanthanide-doped nanoparticles decorated silver nanowires. The proposed method will allow for better clinical characterization, facilitating clinical translation and commercialization of nanoparticle-based thermal therapies.