| Project/Area Number |
25KF0019
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
菅 裕明 東京大学, 大学院理学系研究科(理学部), 教授 (00361668)
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| Co-Investigator(Kenkyū-buntansha) |
YE XIYUN 東京大学, 大学院理学系研究科(理学部), 外国人特別研究員
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| Project Period (FY) |
2025-04-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2025)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2026: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2025: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Outline of Research at the Start |
This project develops a ribosomal system to incorporate γ-unsaturated amino acids (gAAs) into peptides using flexizyme-charged tRNAs and the FIT system. Synthesized gAA-CMEs with diverse sidechains enable formation of thiol-ether-cyclized macrocyclic peptide libraries. These are screened via mRNA display against targets like Pin1 and HPV16 E6. Outcomes include novel peptide inhibitors, a flexible mRNA display toolkit, and insights into ribosomal tolerance for non-proteinogenic monomers.
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