脊椎動物の季節感知システムの設計原理の解明とその応用

• Project/Area Number: 26000013
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: 吉村 崇 名古屋大学, 生命農学研究科(WPI), 教授 (40291413)
• Project Period (FY): 2014 – 2018
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥383,240,000 (Direct Cost: ¥294,800,000、Indirect Cost: ¥88,440,000); Fiscal Year 2018: ¥62,530,000 (Direct Cost: ¥48,100,000、Indirect Cost: ¥14,430,000); Fiscal Year 2017: ¥69,290,000 (Direct Cost: ¥53,300,000、Indirect Cost: ¥15,990,000); Fiscal Year 2016: ¥88,790,000 (Direct Cost: ¥68,300,000、Indirect Cost: ¥20,490,000); Fiscal Year 2015: ¥95,160,000 (Direct Cost: ¥73,200,000、Indirect Cost: ¥21,960,000); Fiscal Year 2014: ¥67,470,000 (Direct Cost: ¥51,900,000、Indirect Cost: ¥15,570,000)
• Keywords: 光周性 / 概日リズム / 季節繁殖 / 既存薬 / 畜産学 / 生理学 / ゲノム / スクリーニング / 合成化学 / 臨界日長

Outline of Annual Research Achievements

動物は毎年繰り返し訪れる環境の季節変化に対し、より良く適応するために、光や温度などの外的変化を感知し、繁殖、渡り、ストレス応答などの生理機能や行動を制御している。このような動物の季節変化については、アリストテレスの著書「動物誌」にも詳述されていたが、その仕組みは謎に包まれていた。本研究では様々な動物の持つ洗練された能力に着目することで脊椎動物の季節適応機構の設計原理を解明することを目標とした。また季節適応を制御する革新的機能分子を創出することで、動物の生産性の向上やヒトの季節性疾患の克服を実現することを目指した。
まず、メダカが生息地域の緯度に応じて異なる日長応答、温度応答を示すことを見出し、遺伝解析を実施した結果、日長、温度をそれぞれ規定する有力な候補遺伝子を同定することに成功した。現在、それらの候補遺伝子の機能を検討している。また、動物は繁殖期になるとストレス応答を増加させることが知られていたが、その分子基盤は謎だった。トランスクリプトーム解析を実施した結果、long non-coding RNAがストレス応答の季節変化を制御していることを明らかにした(Nat Ecol Evol, 2019)。高緯度地域では、冬季にうつ病を発症する冬季うつ病が深刻な社会問題になっている。冬季うつ病を含む様々な精神障害の患者においては概日時計に異常をきたしていることが知られているため、概日時計を調節する分子を既存薬から探索したところ、細胞レベルで体内時計の周期を調節するとともに、混餌投与によって体内時計の周期を調節する薬を発見することに成功した(EMBO Mol Med 2018)。またメダカをモデルとして冬季の社会性の低下を改善する既存薬をスクリーニングしたところ、社会性を改善する漢方薬成分を発見することに成功した。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Int'l Joint Research] マンチェスター大学/インペリアルカレッジ(英国)
• [Int'l Joint Research] クイーンズランド大学(オーストラリア)
• [Int'l Joint Research] シカゴ大学/アメリカ国立衛生研究所(米国)
• [Int'l Joint Research] クイーンズ大学(カナダ)
• [Int'l Joint Research] トロムソ大学(ノルウェー)
• [Int'l Joint Research] マンチェスター大学/インペリアルカレッジ(英国)
• [Int'l Joint Research] クイーンズランド大学(オーストラリア)
• [Int'l Joint Research] クイーンズ大学(カナダ)
• [Int'l Joint Research] トロムソ大学(ノルウェー)
• [Int'l Joint Research] シカゴ大学(米国)
• [Int'l Joint Research] マンチェスター大学/インペリアルカレッジ/ロスリン研究所(英国)
• [Int'l Joint Research] クイーンズランド大学(オーストラリア)
• [Int'l Joint Research] クイーンズ大学(カナダ)
• [Int'l Joint Research] トロムソ大学(ノルウェー)
• [Int'l Joint Research] シカゴ大学(米国)
• [Int'l Joint Research] シカゴ大学(米国)
• [Int'l Joint Research] マンチェスター大学/エディンバラ大学/インペリアルカレッジ(英国)
• [Int'l Joint Research] トロムソ大学(ノルウェー)
• [Journal Article] 脊椎動物の季節感知機構の解明とその応用 (2019)
  • Author(s): NAKAYAMA Tomoya、NAKANE Yusuke、YOSHIMURA Takashi
  • Journal Title: KAGAKU TO SEIBUTSU Volume: 57 Issue: 2 Pages: 121-128
  • DOI: 10.1271/kagakutoseibutsu.57.121
  • NAID: 130007787410
  • ISSN: 0453-073X, 1883-6852
  • Year and Date: 2019-01-20
• [Journal Article] Seasonally regulation of the lncRNA LDAIR modulates self-protective behaviors during the breeding season. (2019)
  • Author(s): Nakayama T., Shimmura, T., Shinomiya, A., Okimura, K., Takehana,Y., Furukawa, Y., Shimo, T., Senga, T., Nakatsukasa, M., Nishimura, T., Tanaka, M., Okubo, K., Kamei, Y., Naruse, K. and Yoshimura, T.
  • Journal Title: Nature Eco. Evol. Volume: 3 Issue: 5 Pages: 845-852
  • DOI: 10.1038/s41559-019-0866-6
  • Peer Reviewed / Open Access
• [Journal Article] Cholecystokinin induces crowing in chickens (2019)
  • Author(s): Shimmura T, Tamura M, Ohashi S, Sasaki A, Yamanaka T, Nakao N, Ihara K, Okamura S, Yoshimura T.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 3978-3978
  • DOI: 10.1038/s41598-019-40746-9
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior (2019)
  • Author(s): Ota W, Nakane Y, Kashio M, Suzuki Y, Nakamura K, Mori Y, Tominaga M, Yoshimura T
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 3706-3706
  • DOI: 10.1038/s41598-019-40067-x
  • NAID: 120006817612
  • Peer Reviewed / Open Access
• [Journal Article] Photoperiodic Regulation of Reproduction in Vertebrates (2019)
  • Author(s): Nakane Yusuke、Yoshimura Takashi
  • Journal Title: Annual Review of Animal Biosciences Volume: 7 Issue: 1 Pages: 173-194
  • DOI: 10.1146/annurev-animal-020518-115216
  • Peer Reviewed
• [Journal Article] 体内時計を標的とした創薬 (2019)
  • Author(s): 吉村崇
  • Journal Title: 実験医学 Volume: 37 Pages: 398-399
• [Journal Article] Interconnection between circadian clocks and thyroid function (2019)
  • Author(s): Ikegami K, Refetoff S, van Cauter E, Yoshimura T
  • Journal Title: Nature Reviews Endocrinology
  • NAID: 120006775102
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of circadian clock modulators from existing drugs (2018)
  • Author(s): T. Katherine Tamai, Yusuke Nakane, Wataru Ota, Akane Kobayashi, Masateru Ishiguro, Naoya Kadofusa, Keisuke Ikegami, Kazuhiro Yagita, Yasufumi Shigeyoshi, Masaki Sudo, Taeko Nishiwaki-Ohkawa, Ayato Sato, & Takashi Yoshimura
  • Journal Title: EMBO Molecular Medicine Volume: - Issue: 5
  • DOI: 10.15252/emmm.201708724
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired circadian photoentrainement in Opn5-null mice (2018)
  • Author(s): Ota W, Nakane Y, Hatter S, Yoshimura T
  • Journal Title: iScience Volume: 6 Pages: 299-305
  • DOI: 10.1016/j.isci.2018.08.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Seasonal rhythms : the role of thyrotropin and thyroid hormones (2018)
  • Author(s): Nakayama T, Yoshimura T
  • Journal Title: Thyroid Volume: 28 Issue: 1 Pages: 43-200
  • DOI: 10.1089/thy.2017.0186
  • Peer Reviewed
• [Journal Article] Seasonal changes in color perception (2018)
  • Author(s): Shimmura T, Nakayama T, Shinomiya A, Yoshimura T
  • Journal Title: General and Comparative Endcrinology Volume: 260 Pages: 171-174
  • DOI: 10.1016/j.ygcen.2017.12.010
  • Peer Reviewed
• [Journal Article] Dynamic plasticity in phototransduction regulates seasonal changes in color perception (2017)
  • Author(s): Shimmura Tsuyoshi、Nakayama Tomoya、Shinomiya Ai、Fukamachi Shoji、Yasugi Masaki、Watanabe Eiji、Shimo Takayuki、Senga Takumi、Nishimura Toshiya、Tanaka Minoru、Kamei Yasuhiro、Naruse Kiyoshi、Yoshimura Takashi
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 412-412
  • DOI: 10.1038/s41467-017-00432-8
  • Peer Reviewed / Open Access
• [Journal Article] The hypothalamic-pituitary-thyroid axis and biological rhythms: The discovery of TSH's unexpected role using animal models (2017)
  • Author(s): Keisuke Ikegami & Takashi Yoshimura
  • Journal Title: Best Practice & Research Clinical Endocrinology & Metabolism Volume: 31 Issue: 5 Pages: 475-485
  • DOI: 10.1016/j.beem.2017.09.002
  • NAID: 120006473528
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular basis for regulating seasonal reproduction in vertebrates (2016)
  • Author(s): Nishiwaki-Ohkawa T, Yoshimura T
  • Journal Title: Journal of Endocrinology Volume: 229 Issue: 3 Pages: R117-R127
  • DOI: 10.1530/joe-16-0066
  • Peer Reviewed / Open Access
• [Journal Article] 組織特異的TSH糖鎖修飾 (2016)
  • Author(s): 池上啓介、吉村崇
  • Journal Title: 月刊Mebio Volume: 33 Pages: 175-188
• [Journal Article] 脊椎動物の光周性の制御機構 (2016)
  • Author(s): 中根右介、吉村崇
  • Journal Title: 生体の科学 Volume: 67 Pages: 1-4
• [Journal Article] 春告げホルモンTSHが甲状腺を刺激しない仕組み (2016)
  • Author(s): 吉村崇
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 42 Pages: 58-62
  • NAID: 40020734471
• [Journal Article] Comparative analysis reveals the underlying mechanism of vertebrate seasonal reproduction (2016)
  • Author(s): Ikegami K, Yoshimura T
  • Journal Title: General and Comparative Endocrinology Volume: 227 Pages: 64-68
  • DOI: 10.1016/j.ygcen.2015.05.009
  • Peer Reviewed
• [Journal Article] なぜ動物は種特有の鳴き方ができるのか? ニワトリの「コケコッコー」を用いた先天的発声の研究 (2016)
  • Author(s): 新村毅, 吉村崇
  • Journal Title: 実験医学 Volume: 34 Pages: 618-621
• [Journal Article] C-H Activation Generates Period-Shortening Moleculaes That Target Cryptochrome in the Mammalian Circadian Clock. (2015)
  • Author(s): Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Okawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irie S, Kay SA, Yoshimura T, Itami K.
  • Journal Title: Angew Chem Int Ed Volume: 54 Issue: 24 Pages: 7193-7197
  • DOI: 10.1002/anie.201502942
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The highest-ranking rooster has priority to announce the break of dawn (2015)
  • Author(s): Shimmura T, Ohashi S, Yoshimura T
  • Journal Title: Scientific Reports Volume: ５ Issue: 1 Pages: 1-9
  • DOI: 10.1038/srep11683
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ontogeny of the saccus vasculosus, a seasonal sensor in fish (2015)
  • Author(s): Maeda R, Shimo T, Nakane Y, Nakao N, Yoshimura
  • Journal Title: Endocrinology Volume: 156 Issue: 11 Pages: 4238-4243
  • DOI: 10.1210/en.2015-1415
  • Peer Reviewed
• [Journal Article] Lactic acid is a sperm motility inactivation factor in the sperm storage tubules. (2015)
  • Author(s): Matsuzaki M, Mizushima S, Hiyama G, Hirohashi N, Shiba K, Inaba K, Suzuki T, Dohra H, Ohnishi T, Sato Y, Kohsaka T, Ichikawa Y, Atsumi Y, Yoshimura T, Sasanami T.
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 17643-17643
  • DOI: 10.1038/srep17643
  • NAID: 120007128467
  • Peer Reviewed / Open Access
• [Journal Article] 季節感知機構の解析から見えてきた動物の巧みな戦略 (2015)
  • Author(s): 池上啓介, 吉村崇
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 35 Pages: 103-106
• [Journal Article] ホルモンの糖鎖修飾による巧みな生理機能の分担戦略 (2015)
  • Author(s): 池上啓介, 吉村崇
  • Journal Title: 比較内分泌学 Volume: 41 Pages: 129-130
  • NAID: 130005103622
• [Journal Article] Disrupted seasonal biology impacts health, food security, and ecosystems (2015)
  • Author(s): Stevenson TJ, Yoshimura T, 他34名
  • Journal Title: Proceedings of the Royal Society B Volume: 282 Issue: 1817 Pages: 1817-1817
  • DOI: 10.1098/rspb.2015.1453
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 触媒で体内時計のリズムを変えるー異分野融合がもたらした新分子の発見 (2015)
  • Author(s): 伊丹健一郎, 吉村崇
  • Journal Title: 月刊化学 Volume: 70 Pages: 32-36
• [Journal Article] Different Photoperiodic Responses in Four Lines of Japanese Quail (2015)
  • Author(s): Atsumi Y, Yorinaga E, Ota W, Yoshimura T
  • Journal Title: The Journal of Poultry Science Volume: 53 Issue: 1 Pages: 63-66
  • DOI: 10.2141/jpsa.0150097
  • NAID: 130005120951
  • ISSN: 1346-7395, 1349-0486
  • Peer Reviewed
• [Journal Article] A unique mechanism of successful fertilization in a domestic bird. (2015)
  • Author(s): T. Sasanami, S. Izumi, N. Sakurai, T. Hirata, S. Mizushima, M. Matsuzaki, G. Hiyama, E. Yorinaga, T. Yoshimura, K. Ukena and K. Tsutsui
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 7700-7700
  • DOI: 10.1038/srep07700
  • NAID: 120005527162
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intrinsic photosensitivity of deep brain photoreceptor (2014)
  • Author(s): Nakane, Y., Shimmura, T., Abe, H. and Yoshimura, T.
  • Journal Title: Current Biology Volume: 24 Issue: 13 Pages: R596-R597
  • DOI: 10.1016/j.cub.2014.05.038
  • Peer Reviewed
• [Journal Article] Thyrotropin receptor knockout changes monoaminergic neuronal system and produces methylphenidate-sensitive emotional and cognitive dysfunction (2014)
  • Author(s): Mouri A, Hoshino Y, Narusawa S, Ikegami K, Mizoguchi H, Murata Y, Yoshimura T, Nabeshima T
  • Journal Title: Psychoneuroendocrinology Volume: 48 Pages: 147-161
  • DOI: 10.1016/j.psyneuen.2014.05.021
  • Peer Reviewed
• [Journal Article] Tissue-specific post-translational modification allows functional targeting of thyrotropin (2014)
  • Author(s): Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T
  • Journal Title: Cell Reports Volume: 9 Issue: 3 Pages: 801-809
  • DOI: 10.1016/j.celrep.2014.10.006
  • Peer Reviewed / Open Access
• [Journal Article] Universality and diversity in the signal transduction pathway that regulates seasonal reproduction in vertebrates (2014)
  • Author(s): Nakane Y, Yoshimura T.
  • Journal Title: Frontiers in Neuroscience Volume: 5 Pages: 115-115
  • DOI: 10.3389/fnins.2014.00115
  • Peer Reviewed
• [Journal Article] 季節リズムの制御メカニズム (2014)
  • Author(s): 大川妙子、吉村崇
  • Journal Title: 睡眠医療 Volume: 8 Pages: 203-209
• [Journal Article] 魚類の季節センサー (2014)
  • Author(s): 中根右介、池上啓介、飯郷雅之、吉村崇
  • Journal Title: 比較内分泌学 Volume: 40 Pages: 65-67
• [Journal Article] Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression. (2014)
  • Author(s): K. Ikegami, Y. Atsumi, E. Yorinaga, H. Ono, I. Murayama1, Y. Nakane, W. Ota, N. Arai, A. Tega, M. Iigo, V. M. Darras, K. Tsutsui, Y. Hayashi, S. Yoshida and T. Yoshimura
  • Journal Title: Endocrinology Volume: 56 Issue: 2 Pages: 647-659
  • DOI: 10.1210/en.2014-1741
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Seasonal rhythms : Towards understanding winter depression (2019)
  • Author(s): Yoshimura T
  • Organizer: The 5th CSRS-ITbM Joint Workshop
  • Int'l Joint Research / Invited
• [Presentation] 脊椎動物の季節のリズム (2019)
  • Author(s): 吉村崇
  • Organizer: 生物・化学・数理科学から見抜くリズム現象
  • Invited
• [Presentation] 動物の巧みな生存戦略に学び、食と健康の未来を開拓する : 異分野融合研究で体内時計を理解し、制御する (2019)
  • Author(s): 吉村崇
  • Organizer: テクノ未来塾 第174回「名古屋フォーラム」
  • Invited
• [Presentation] Molecular and neuroendocrine mechanism of vertebrate seasonal reproduction (2019)
  • Author(s): Yoshimura T
  • Organizer: Workshop on Time Brain and Behavior
  • Int'l Joint Research / Invited
• [Presentation] Molecular basis of seasonal changes in behavior (2019)
  • Author(s): Yoshimura T
  • Organizer: International Symposium on Biological Rhythms
  • Int'l Joint Research / Invited
• [Presentation] Effects of temperature on seasonal adaptation. Towards the understanding of human seasonality (2019)
  • Author(s): Yoshimura T
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress
  • Int'l Joint Research / Invited
• [Presentation] Medaka as a model to understand the underlying mechanism of vertebrate seasonal adaptation (2018)
  • Author(s): Yoshimura T
  • Organizer: 4th Strategic Meeting for Medaka Research
  • Int'l Joint Research / Invited
• [Presentation] Seasonal adaptation mechanism in Medaka (2018)
  • Author(s): Yoshimura T
  • Organizer: Society for Research on Biological Rhythms 2018
  • Int'l Joint Research / Invited
• [Presentation] Seasonal changes in color perception and behavior in medaka (2018)
  • Author(s): Yoshimura T
  • Organizer: 8th Intercongress of the Asia and Oceania Society for Comparative Endocrinology
  • Int'l Joint Research / Invited
• [Presentation] Seasonal adaptation mechanism in medaka fish (2018)
  • Author(s): Yoshimura T
  • Organizer: Asian Forum on Chronobiology
  • Int'l Joint Research / Invited
• [Presentation] Seasonal adaptation mechanism in Medaka (2018)
  • Author(s): Yoshimura T
  • Organizer: International Congress of Neuroendocrinology 2018
  • Int'l Joint Research / Invited
• [Presentation] 動物の季節適応機構の解明とその応用 : ヒトの季節リズムの理解にむけて (2018)
  • Author(s): 吉村崇
  • Organizer: 電気泳動学会
  • Invited
• [Presentation] Molecular basis of vertebrate seasonal adaptation : Towards understanding the human seasonal rhythms (2018)
  • Author(s): Yoshimura T
  • Organizer: 13th International Workshop on Resistance to Thyroid Hormones (IWRTH)
  • Int'l Joint Research / Invited
• [Presentation] 動物が季節を感じる仕組み : ヒトの冬季うつ病の理解と克服に向けて (2018)
  • Author(s): 吉村崇
  • Organizer: 「認識と形成」研究会
  • Invited
• [Presentation] 動物が季節を感じる仕組みの解明 : ヒトの冬季うつ病の理解と克服に向けて (2018)
  • Author(s): 吉村崇
  • Organizer: 大隅基礎科学創成財団 第2回創発セミナー「生物の“体内時計”を探り、操作する」
  • Invited
• [Presentation] 動物の季節適応機構 : 動物から冬季うつ病を理解できるのか (2018)
  • Author(s): 吉村崇
  • Organizer: 先進新診断システム研究会
  • Invited
• [Presentation] Molecular basis of vertebrate seasonal adaptation : Towards the understanding of human seasonal rhythms (2018)
  • Author(s): Yoshimura T
  • Organizer: 12th Annual Salk / Foundation Ipsen / Science Symposium on Biological Complexity- the biology of TIME circadian, lunar and seasonal rhythms
  • Int'l Joint Research / Invited
• [Presentation] 比較生物学と異分野融合研究による季節適応機構の理解とその制御 (2018)
  • Author(s): 吉村崇
  • Organizer: 日本農芸化学会 2018年度大会
  • Invited
• [Presentation] Mechanism of seasonal adaptation and its application (2017)
  • Author(s): Yoshimura T
  • Organizer: International Symposium on Biological Timang and Health Issues in the 21st Century
  • Place of Presentation: University of Delhi, India
  • Year and Date: 2017-02-24
  • Int'l Joint Research / Invited
• [Presentation] Understanding the molecular basis of vertebrate seasonal adaptation (2017)
  • Author(s): Yoshimura T
  • Organizer: 18th International Congress of Comparative Endocrinology
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the seasonal adaptation mechanisms in vertebrates (2017)
  • Author(s): Yoshimura T
  • Organizer: Medaka Genome Conference
  • Invited
• [Presentation] Understanding the mechanism of vertebrate seasonal adaptation (2017)
  • Author(s): Yoshimura T
  • Organizer: IoC-IPMB-ITbM Joint Symposium on New Frontiers by fusing Chemistry and Biology
  • Int'l Joint Research / Invited
• [Presentation] Molecular basis of vertebrate seasonal adaptation (2017)
  • Author(s): Yoshimura T
  • Organizer: European Society for Evolutionary Biology EBES XVI Congress
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the mechanism of human seasonal rhythms : an interdisciplinary approach (2017)
  • Author(s): Yoshimura T
  • Organizer: The 20th Annual Meeting of the Korean Society for Brain and Neural Science “Challenge the Brain, Change the Future”
  • Int'l Joint Research / Invited
• [Presentation] メダカの体色と色覚の季節適応 (2017)
  • Author(s): 吉村崇
  • Organizer: 日本動物学会第88回大会
  • Invited
• [Presentation] 脊椎動物の環境周期への適応機構 (2017)
  • Author(s): 吉村崇
  • Organizer: 日本時間生物学会学術大会
  • Invited
• [Presentation] Seasonal adaptation from the perspective of vertebrate reproduction (2017)
  • Author(s): Yoshimura T
  • Organizer: ConBio2017
  • Invited
• [Presentation] Universality and diversity in the mechanism of vertebrate seasonal adaptation (2016)
  • Author(s): Yoshimura T
  • Organizer: The 87th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-11-17
  • Int'l Joint Research / Invited
• [Presentation] TSH, THの新機能 : 比較生物学と発見駆動型研究のすすめ (2016)
  • Author(s): 吉村崇
  • Organizer: 第59回日本甲状腺学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-05
  • Invited
• [Presentation] Understanding the mechanism of seasonal time measurement using interdisciplinary approach (2016)
  • Author(s): Yoshimura T
  • Organizer: The 29th Conference of the International Society for Chronobiology
  • Place of Presentation: Suzhou, China
  • Year and Date: 2016-10-26
  • Int'l Joint Research / Invited
• [Presentation] Sensing light within the deep brain (2016)
  • Author(s): Yoshimura T
  • Organizer: International Symposium on Avian Endocrinology (ISAE2016)
  • Place of Presentation: Niagara-on-the-lake, Canada
  • Year and Date: 2016-10-11
  • Int'l Joint Research / Invited
• [Presentation] Universality and diversity in the photoperiodic signal transduction in vertebrates (2016)
  • Author(s): Yoshimura T
  • Organizer: 28th Conference of European Comparative Endocrinologists
  • Place of Presentation: Leuven, Belgium
  • Year and Date: 2016-08-25
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the mechanism of seasonal time measurement (2016)
  • Author(s): Yoshimura T
  • Organizer: Leopoldina Symposium of Seasonal Rhythms
  • Place of Presentation: Leuven, Belgium
  • Year and Date: 2016-08-25
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the mechanism of seasonal reproduction : an interdisciprinaly approach (2016)
  • Author(s): Yoshimura T
  • Organizer: Penn State Department of Animal Science Seminar
  • Place of Presentation: State College, USA
  • Year and Date: 2016-08-05
  • Invited
• [Presentation] Towards understanding the mechanism of seasonal reproduction : an interdisciprinaly approach (2016)
  • Author(s): Yoshimura T
  • Organizer: North Carolina State University Prestage Department of Poultry Science Seminar
  • Place of Presentation: North Carolina State University, USA
  • Year and Date: 2016-08-03
  • Invited
• [Presentation] 脊椎動物の季節感知機構 : ヒトの季節性疾患の理解に向けて (2016)
  • Author(s): 吉村崇
  • Organizer: 20th Cardiovascular Metabolism and Aging Conference
  • Place of Presentation: 東京
  • Year and Date: 2016-07-08
  • Invited
• [Presentation] 脊椎動物の季節感知機構の解明に向けて (2016)
  • Author(s): 吉村崇
  • Organizer: 新学術領域 「温度生物学」 第1回若手の会
  • Place of Presentation: 北海道大学
  • Year and Date: 2016-06-30
  • Invited
• [Presentation] Towards understanding the mechanism of seasonal time measurement (2016)
  • Author(s): Yoshimura T
  • Organizer: 8th Congress of Asia and Oceania Society for Comparative Endocrinology "From Comparative to Translationa Research"
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-06-23
  • Int'l Joint Research / Invited
• [Presentation] Thyroid hormone and seasonal regulation of reproduction (2016)
  • Author(s): Yoshimura T
  • Organizer: IBSA Foundation Symposium "the thyroid … in the periphery!"
  • Place of Presentation: Naples, Italy
  • Year and Date: 2016-04-15
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the mechanism of seasonal the measurement : an interdisciplinary approach (2016)
  • Author(s): Yoshimura T
  • Organizer: 64th NIBB Conference "Evolution of Seasonal Timers"
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2016-04-15
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the mechanism of seasonal reproduction in vertebrates (2016)
  • Author(s): Yoshimura T
  • Organizer: Avian Model Systems 9 : A New Integrative Platform
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-03-31
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] 脊椎動物の光周性の制御機構に関する研究 (2015)
  • Author(s): 吉村崇
  • Organizer: 比較内分泌学会
  • Place of Presentation: 広島
  • Year and Date: 2015-12-13
  • Description: 【発表確定】
  • Invited
• [Presentation] Regulatory mechanisms of seasonal reproduction in vertebrates (2015)
  • Author(s): Yoshimura T
  • Organizer: 8th Federation of the Asian and Oceanian Physiological Society (FAOPS) Congress
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-25
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] 脊椎動物の日長測定機構の解明に向けて (2015)
  • Author(s): 吉村崇
  • Organizer: 日本時間生物学会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2015-11-22
  • Description: 【発表確定】
  • Invited
• [Presentation] Roles of TSH from pars tuberalis and pars distalis (2015)
  • Author(s): Yoshimura T
  • Organizer: 5th International Thyroid Congress
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-10-20
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Novel roles for TSH and TH identified by discovery-driven approach (2015)
  • Author(s): Yoshimura T
  • Organizer: 15th International Thyroid Congress (Van Meter賞受賞講演)
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-10-19
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Understanding the mechanism of seasonal time measurement (2015)
  • Author(s): Yoshimura T
  • Organizer: The 58th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: 大宮(埼玉)
  • Year and Date: 2015-09-11
  • Description: 【発表確定】
  • Invited
• [Presentation] Understanding the mechanism of vertebrate photoperiodism by comparative approach (2015)
  • Author(s): Yoshimura T
  • Organizer: The 9th International Congress of Comparative Physiology and Biochemistry (ICCPB2015)
  • Place of Presentation: Krakow, Poland
  • Year and Date: 2015-08-24
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Towards understanding the mechanism of seasonal time measurement (2015)
  • Author(s): Yoshimura T
  • Organizer: XIV European Biological Rhythms Society (EBRS) and IV World Chronobiology Congress (WCC)
  • Place of Presentation: Manchester, UK
  • Year and Date: 2015-08-04
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Mechanism of seasonal time measurement in vertebrates (2015)
  • Author(s): Yoshimura T
  • Organizer: Chronobiology Gordon Research Conference
  • Place of Presentation: Girona, Spain
  • Year and Date: 2015-06-30
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] Understanding the mechanism of seasonal time measurement and development of transformative bio-molecules (2015)
  • Author(s): Yoshimura T
  • Organizer: The 3rd International Symposium on Transformative Bio-Molecules (ISTbM-3)
  • Place of Presentation: 名古屋大学(名古屋)
  • Year and Date: 2015-05-26
  • Description: 【発表確定】
  • Int'l Joint Research / Invited
• [Presentation] 組織特異的翻訳後修飾による甲状腺刺激ホルモンの機能分化 (2015)
  • Author(s): 吉村崇
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ(東京)
  • Year and Date: 2015-04-23
  • Description: 【発表確定】
  • Invited
• [Presentation] 季節感地機構の解析から見えてきた動物の巧みな戦略 (2015)
  • Author(s): 吉村崇
  • Organizer: 第58回脳の医学・生物学研究会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-01-10
  • Description: 【発表確定】
  • Invited
• [Presentation] 脊椎動物の光周性の制御機構の共通性と多様性 (2014)
  • Author(s): 吉村崇
  • Organizer: 第21回日本時間生物学会
  • Place of Presentation: 九州大学
  • Year and Date: 2014-11-08
  • Description: 【発表確定】
  • Invited
• [Presentation] Understanding the underlying mechanism of seasonal time measurement using various vertebrate species (2014)
  • Author(s): Yoshimura T
  • Organizer: The 68th Fujihara Seminar, Homeodynamics in Clocks, Sleep and Metabolism
  • Place of Presentation: Izu, Japan
  • Year and Date: 2014-09-26
  • Description: 【発表確定】
  • Invited
• [Presentation] Evolution and origin of seasonal sensor in vertebrates (2014)
  • Author(s): Yoshimura T
  • Organizer: 16th International Congress of Photobiology
  • Place of Presentation: Cordoba, Argentina
  • Year and Date: 2014-09-10
  • Description: 【発表確定】
  • Invited
• [Presentation] Universality and diversity in the mechanism of vertebrate seasonal reproduction (2014)
  • Author(s): Yoshimura T
  • Organizer: 30th Anniversary Symposiumu of Sapporo Symposium on Biological Rhythm
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2014-07-27
  • Description: 【発表確定】
  • Invited
• [Presentation] Evolution and origin of vertebrate seasonal sensor (2014)
  • Author(s): Yoshimura T
  • Organizer: Society for Research on Biological Rhythms(SRBR2014)
  • Place of Presentation: Big Sky, Montana, USA
  • Year and Date: 2014-06-17
  • Description: 【発表確定】
  • Invited
• [Presentation] 動物が日照時間の変化を感知して季節を知る仕組みの解明 (2014)
  • Author(s): 吉村崇
  • Organizer: 第11回AMO討論会
  • Place of Presentation: 大阪大学
  • Year and Date: 2014-06-06
  • Description: 【発表確定】
  • Invited
• [Book] Reproductive and Developmental Strategies (Kobayashi K, Kitano T, Iwao Y, Kondo Meds.) (2018)
  • Author(s): Shinomiya A, Yoshimura T
  • Pages: 103-122
  • Total Pages: 790
  • Publisher: Springer Japan
• [Book] 動物学の百科事典(公益社団法人日本動物学会編) (2018)
  • Author(s): 中根右介、吉村崇
  • Pages: 462-465
  • Total Pages: 800
  • Publisher: 丸善出版
• [Book] 魚類学の百科事典(一般社団法人日本魚類学会編) (2018)
  • Author(s): 中根右介、吉村崇
  • Total Pages: 704
  • Publisher: 丸善出版
• [Book] Encyclopedia of Reproduction (Michael Skinner ed) (2018)
  • Author(s): Nakane Y, Yoshimura T
  • Pages: 409-414
  • Total Pages: 3868
  • Publisher: Academic Press : Elsevier Inc.
• [Book] Avian Reproduction (Sasanami T ed) (2017)
  • Author(s): Tamai TK, Yoshimura T
  • Total Pages: 214
  • Publisher: Springer
• [Book] Biological Timekeeping : Clocks, Rhythms and Behaviour (Kumar V ed) (2017)
  • Author(s): Ikegami K, Yoshimura T
  • Total Pages: 662
  • Publisher: Springer
• [Book] Avian Endocrinology (Sasanami T ed.) (2017)
  • Author(s): Tamai TK, Yoshimura T
  • Publisher: Springer
  • Description: 印刷中
• [Book] Reproductive and Developmental Strategies (Kobayashi K, Kitano T, Iwao Y, Kondo M, eds) (2017)
  • Author(s): Shinomiya A, Yoshimura T
  • Publisher: Springer
  • Description: 印刷中
• [Book] ホルモンから見た生命現象と進化シリーズⅡ「発生・変態・リズム-時-」(天野勝文、田川正朋共編) (2016)
  • Author(s): 新村毅、吉村崇
  • Total Pages: 212
  • Publisher: 裳華房
• [Book] Annual Review 2016 糖尿病・代謝・内分泌 寺内康夫・伊藤裕・石橋俊 編 (2016)
  • Author(s): 吉村崇
  • Total Pages: 233
  • Publisher: 中外医学社
  • Description: 【発行確定】
• [Book] Sturkie's Avian Physiology Sixth Edition, Scanes CG ed (2014)
  • Author(s): Cassone VM, Yoshimura T
  • Total Pages: 1028
  • Publisher: Academic Press, London
  • Description: 【発行確定】
• [Remarks] 名古屋大学大学院生命農学研究科 動物統合生理学研究室ホームページ
  • URL: https://www.agr.nagoya-u.ac.jp/~aphysiol/
• [Remarks]
  • URL: http://www.itbm.nagoya-u.ac.jp/en/research/2017/09/Yoshimura-Medaka.php
• [Remarks]
  • URL: http://www.nibb.ac.jp/pressroom/news/2017/09/04.html
• [Remarks]
  • URL: https://www.agr.nagoya-u.ac.jp/~aphysiol/
• [Remarks]
  • URL: http://www.itbm.nagoya-u.ac.jp/en/members/t-yoshimura/
• [Remarks] 名古屋大学トランスフォーマティブ生命分子研究所ホームページ
  • URL: http://www.itbm.nagoya-u.ac.jp/ja/research/2015/06/Itami-Yoshimura-Irle-Clock.php
• [Remarks] 名古屋大学トランスフォーマティブ生命分子研究所ホームページ
  • URL: http://www.itbm.nagoya-u.ac.jp/ja/research/2015/07/Yoshimura-Rooster.php
• [Remarks]
  • URL: http://www.itbm.nagoya-u.ac.jp/ja/research/
• [Remarks]
  • URL: http://www.aip.nagoya-u.ac.jp/public/nu_research_ja/highlights/detail/0001858.html
• [Remarks]
  • URL: http://www.agr.nagoya-u.ac.jp/~aphysiol/