The Proteasome: Mechanistic Actions and In-depth Physiopathological Analyses

• Project/Area Number: 26000014
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: TANAKA Keiji 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 理事長 (10108871)
• Co-Investigator(Kenkyū-buntansha): MURATA shigeo 東京大学, 薬学研究科(研究院), 教授 (20344070) ; TANAHASHI nobuyuki 鈴鹿医療科学大学, 保健衛生学部, 准教授 (30511927)
• Research Collaborator: KOMATSU masaaki
• Project Period (FY): 2014 – 2019
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥406,640,000 (Direct Cost: ¥312,800,000、Indirect Cost: ¥93,840,000); Fiscal Year 2018: ¥81,770,000 (Direct Cost: ¥62,900,000、Indirect Cost: ¥18,870,000); Fiscal Year 2017: ¥77,610,000 (Direct Cost: ¥59,700,000、Indirect Cost: ¥17,910,000); Fiscal Year 2016: ¥79,170,000 (Direct Cost: ¥60,900,000、Indirect Cost: ¥18,270,000); Fiscal Year 2015: ¥81,770,000 (Direct Cost: ¥62,900,000、Indirect Cost: ¥18,870,000); Fiscal Year 2014: ¥86,320,000 (Direct Cost: ¥66,400,000、Indirect Cost: ¥19,920,000)
• Keywords: タンパク質分解 / ユビキチン / プロテアソーム / オートファジー / マイトファジー / バノオテクノロジー / 脳神経疾患 / 免疫学 / プロテアソーム顆粒 / RAD23B / 液滴 / メンブレンレスオルガネラ / 液-液相分離 / 蛋白質 / バイオテクノロジー / プロテオーム

Outline of Final Research Achievements

The proteasome is a supramolecular proteolytic apparatus. In this study, we challenged comprehensive analyses of the proteasome and its partner “ubiquitin” from action mechanisms to physiopathological roles. Especially, elucidations regarding the formation of proteasome liquid droplets by liquid-liquid phase separation to serve as a proteolytic center, the mechanism of killer T cell repertoire formation by the thymoproteasome, the ubiquitin code, and a selective autophagic elimination pathway of defective mitochondria (mitophagy) by PINK1 and Parkin were breakthrough achievements.

Academic Significance and Societal Importance of the Research Achievements

プロテアソームの液-液相分離による動作原理の解明やユビキチン修飾の構造・機能の多様性の解析は、世界を先導する独創的な成果であり、細胞内タンパク質分解の研究領域に新基軸を拓いた。またPINK1(プロテインキナーゼ)とParkin(ユビキチンリガーゼ)によるマイトファジーの研究はパーキンソン病の発症機構の核心に迫るものであり、他の神経変性疾患などの研究に対する波及効果も大きく社会的インパクトは比類のないものとなった。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Int'l Joint Research] マサチューセッツ大学(米国)
• [Int'l Joint Research] マサチューセッツ大学/シンシナティ小児病院/NIH(米国)
• [Int'l Joint Research] Ottawa Hospital Research Institute(カナダ)
• [Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome (2020)
  • Author(s): Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
  • Journal Title: Nature Volume: 578 Issue: 7794 Pages: 296-300
  • DOI: 10.1038/s41586-020-1982-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The PINK1-Parkin axis: An Overview. (2020)
  • Author(s): Tanaka K.
  • Journal Title: Neurosci Res. Volume: S0168-0102 Pages: 30571-1
  • DOI: 10.1016/j.neures.2020.01.006
  • Peer Reviewed / Open Access
• [Journal Article] Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL (2019)
  • Author(s): Koyano Fumika、Yamano Koji、Kosako Hidetaka、Tanaka Keiji、Matsuda Noriyuki
  • Journal Title: Journal of Biological Chemistry Volume: 294 Issue: 26 Pages: 10300-10314
  • DOI: 10.1074/jbc.ra118.006302
  • NAID: 120006959752
  • Peer Reviewed / Open Access
• [Journal Article] Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes (2019)
  • Author(s): Koyano Fumika、Yamano Koji、Kosako Hidetaka、Kimura Yoko、Kimura Mayumi、Fujiki Yukio、Tanaka Keiji、Matsuda Noriyuki
  • Journal Title: EMBO reports Volume: 20 Issue: 12
  • DOI: 10.15252/embr.201947728
  • NAID: 120006942558
  • Peer Reviewed / Open Access
• [Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells. (2019)
  • Author(s): Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y
  • Journal Title: Cell Reports Volume: 29 Issue: 9 Pages: 2901-2916
  • DOI: 10.1016/j.celrep.2019.10.079
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4 (2019)
  • Author(s): Sato Yusuke、Tsuchiya Hikaru、Yamagata Atsushi、Okatsu Kei、Tanaka Keiji、Saeki Yasushi、Fukai Shuya
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 5708-5708
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  • Peer Reviewed / Open Access
• [Journal Article] Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways (2019)
  • Author(s): Ikeuchi Ken、Tesina Petr、Matsuo Yoshitaka、Sugiyama Takato、Cheng Jingdong、Saeki Yasushi、Tanaka Keiji、Becker Thomas、Beckmann Roland、Inada Toshifumi
  • Journal Title: The EMBO Journal Volume: 38 Issue: 5
  • DOI: 10.15252/embj.2018100276
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thymoproteasome and peptidic self (2019)
  • Author(s): Takahama Y, Ohigashi I, Murata S, Tanaka K.
  • Journal Title: Immunogenetics Volume: 71 Issue: 3 Pages: 217-221
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  • Peer Reviewed / Open Access
• [Journal Article] Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE (2019)
  • Author(s): Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
  • Journal Title: Methods Enzymol Volume: 618 Pages: 135-147
  • DOI: 10.1016/bs.mie.2018.12.032
  • ISBN: 9780128163597
  • Peer Reviewed / Open Access
• [Journal Article] Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology. (2019)
  • Author(s): Yoshida Y, Mizushima T, Tanaka K.
  • Journal Title: Front Physiol. Volume: 10 Pages: 104-104
  • DOI: 10.3389/fphys.2019.00104
  • Peer Reviewed / Open Access
• [Journal Article] Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells (2019)
  • Author(s): Tomaru Utano、Konno Saori、Miyajima Syota、Kimoto Rikuto、Onodera Mari、Kiuchi Shizuka、Murata Shigeo、Ishizu Akihiro、Kasahara Masanori
  • Journal Title: Cell Reports Volume: 26 Issue: 3 Pages: 639-651
  • DOI: 10.1016/j.celrep.2018.12.078
  • NAID: 120006595593
  • Peer Reviewed / Open Access
• [Journal Article] Shigella effector IpaH4.5 targets 19S regulatory subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation. (2019)
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  • Journal Title: Cell Microbiol. Volume: 21 Issue: 3 Pages: e12974-e12974
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  • Peer Reviewed / Open Access
• [Journal Article] Transcriptional regulation of the 26S proteasome by Nrf1 (2018)
  • Author(s): Koizumi S, Hamazaki J, Murata S.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 94 Issue: 8 Pages: 325-336
  • DOI: 10.2183/pjab.94.021
  • NAID: 130007497652
  • ISSN: 0386-2208, 1349-2896
  • Year and Date: 2018-10-11
  • Peer Reviewed / Open Access
• [Journal Article] Structural insights into ubiquitin phosphorylation by PINK1 (2018)
  • Author(s): Okatsu Kei、Sato Yusuke、Yamano Koji、Matsuda Noriyuki、Negishi Lumi、Takahashi Akiko、Yamagata Atsushi、Goto-Ito Sakurako、Mishima Masaki、Ito Yutaka、Oka Toshihiko、Tanaka Keiji、Fukai Shuya
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 10382-10382
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  • Peer Reviewed / Open Access / Int'l Joint Research
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  • Journal Title: Cancer Res. Volume: 78 Pages: 6371-6385
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• [Journal Article] The immunoproteasome and thymoproteasome: functions, evolution and human disease (2018)
  • Author(s): Murata S, Takahama Y, Kasahara M, Tanaka K
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• [Journal Article] PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. (2018)
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• [Journal Article] Nuclear export of ubiquitinated proteins via the UBIN-POST system (2018)
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• [Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains. (2018)
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  • Journal Title: PNAS Volume: 115 Issue: 7 Pages: 1401-1408
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  • Peer Reviewed
• [Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells (2018)
  • Author(s): Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka,K., and Saeki, Y.
  • Journal Title: Nature Commun Volume: 9 Issue: 1 Pages: 524-524
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• [Journal Article] Endosomal Rab cycles regulate Parkin-mediated mitophagy. (2018)
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• [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. (2018)
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• [Journal Article] Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells. (2018)
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• [Journal Article] Cytosolic N-Glycans : Triggers for Ubiquitination Directing Proleasomal and Autophagic Degradation : Molecular Systems for Monitoring Cytosolic N-Glycans as Signals for Unwanted Proteins and Organelles. (2018)
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  • Journal Title: BioEssays Volume: 40 Issue: 3
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• [Journal Article] Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-linked TDP-43 in Drosophila. (2017)
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  • Journal Title: Molecular and Cellular Biology Volume: 3 Issue: 3
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• [Journal Article] A novel approach to assess the ubiquitin-fold modifier 1-system in cells. (2017)
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• [Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus. (2017)
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  • DOI: 10.1038/ncomms14419
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• [Journal Article] Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation (2017)
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• [Journal Article] In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome. (2017)
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  • Journal Title: Mol. Cell Volume: 66 Issue: 4 Pages: 488-502
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• [Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production (2017)
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  • Journal Title: JCI Insight Volume: 2 Issue: 10 Pages: 1-14
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• [Journal Article] Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis. (2017)
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  • Description: 【掲載確定】 in press
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• [Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. (2017)
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  • Journal Title: PLoS Pathog. Volume: 13 Issue: 12 Pages: e1006162-e1006162
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• [Journal Article] Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild type DJ-1. (2016)
  • Author(s): Kojima, W., Kujuro, Y., Okatsu, K., Bruno, Q., Koyano, F., Kimura, M., Yamano, K., Tanaka, K., and Matsuda, N.
  • Journal Title: Genes to Cells Volume: 21 Issue: 7 Pages: 772-788
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy. (2016)
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structural analysis of a function-associated loop mutant of the substrate recognition domain of Fbs1 ubiquitin ligase. (2016)
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling (2016)
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  • Journal Title: Mol. Cell Volume: 64 Issue: 2 Pages: 251-266
  • DOI: 10.1016/j.molcel.2016.09.014
  • Peer Reviewed
• [Journal Article] The ubiquitin signal and autophagy : an orchestrated dance leading to mitochondrial degradation (2016)
  • Author(s): Koji Yamano, K., Matsuda, N., and Tanaka, K.
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  • Journal Title: Elife Volume: 18357 Pages: 18357-18357
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ankrd13 family of ubiquitin-interacting motif-bearing proteins regulates VCP/p97-mediated lysosomal traffic of caveolin-1. (2016)
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  • Journal Title: J. Biol. Chem. Volume: 291 Issue: 12 Pages: 6218-6231
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• [Journal Article] Essential role of specialized proteasome subunits in thymic selection of CD8 T cells (2016)
  • Author(s): Kincaid, E. Z. Murata, S., Tanaka, K., and Rock, K. L.
  • Journal Title: Nat Immunol
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  • Peer Reviewed / Int'l Joint Research
• [Journal Article] p62/Sqstml promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. (2016)
  • Author(s): Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M-S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., and Komatsu, M.
  • Journal Title: Nat Commun.
  • Description: 【掲載確定】 in press
  • Peer Reviewed / Open Access
• [Journal Article] Mutations in the deubiquitinase gene USP8 cause Cushing’s disease (2015)
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  • Journal Title: Nat. Genet. Volume: 47 Issue: 1 Pages: 31-38
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• [Journal Article] Phosphorylated ubiquitin chain is the genuine Parkin receptor. (2015)
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• [Journal Article] VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast (2015)
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• [Journal Article] Ubiquitin acetylation inhibits polyubiquitin chain elongation. (2015)
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  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 6116-6116
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Unconventional PINK1 localization mechanism to the outer membrane of depolarized mitochondria drives Parkin recruitment (2015)
  • Author(s): Okatsu, K., Kimura, M., Oka, T., Tanaka, K., and Matsuda N.
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  • Peer Reviewed / Open Access
• [Journal Article] A comprehensive method for detecting ubiquitinated substrates using TR-TUBE (2015)
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  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 112 Issue: 15 Pages: 4630-4635
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• [Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity. (2015)
  • Author(s): Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
  • Journal Title: Nature communications Volume: 6 Issue: 1 Pages: 6780-6780
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  • NAID: 120006348510
  • Peer Reviewed / Open Access
• [Journal Article] TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells (2015)
  • Author(s): Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
  • Journal Title: Nature Immunology Volume: 16 Issue: 10 Pages: 1069-1076
  • DOI: 10.1038/ni.3237
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. (2015)
  • Author(s): Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.
  • Journal Title: Nature Communications Volume: 6 Issue: 1 Pages: 7484-7484
  • DOI: 10.1038/ncomms8484
  • NAID: 120006999409
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipocyte activator PPAR gamma. (2015)
  • Author(s): Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K. and Hatakeyama, S.
  • Journal Title: eLIFE Volume: 4
  • DOI: 10.7554/elife.05615
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Measurement of proteasome activity in peripheral blood mononuclear cells as an indicator of susceptibility to bortezomib-induced severe neurological adverse events in patients with multiple myeloma (2015)
  • Author(s): Cho, Y., Hori, M., Okoshi, Y., Fujisawa, F., Shinagawa, A., Kudo, D., Komeno, T., Yoshida, C., Katsura, Y., Ota, I., Shimizu, S., Kamoshita, M., Sasaki, K., Tanaka, K., Mukai, H. Y., and Kojima, H.
  • Journal Title: Acta Haematol. Volume: 134 Issue: 1 Pages: 25-31
  • DOI: 10.1159/000369445
  • Peer Reviewed
• [Journal Article] Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins (2015)
  • Author(s): Yoko Kimura, Mirai Tanigawa, Junko Kawawaki, Kenji Takagi, Tsunehiro Mizushima, Tatsuya Maeda, Keiji Tanaka
  • Journal Title: Eukaryotic Cell Volume: 14 Issue: 10 Pages: 976-982
  • DOI: 10.1128/ec.00091-15
  • NAID: 120005671359
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation. (2015)
  • Author(s): Koji Yamano, Bruno B. Queliconi, Fumika Koyano, Yasushi Saeki, Takatsugu Hirokawa, Keiji Tanaka§,and Noriyuki Matsuda
  • Journal Title: The Journal of Biological Chemistry Volume: 290 Issue: 42 Pages: 25199-25211
  • DOI: 10.1074/jbc.m115.671446
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3. (2015)
  • Author(s): Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.
  • Journal Title: PLoS One. Volume: 10 Issue: 10 Pages: e0140366-e0140366
  • DOI: 10.1371/journal.pone.0140366
  • Peer Reviewed / Open Access
• [Journal Article] Liganded ERα stimulates the E3 ubiquitin ligase activity of UBE3C to facilitate cell proliferation (2015)
  • Author(s): Okada M, Ohtake F, Nishikawa H, Wu W, Saeki Y, Takana K, Ohta T
  • Journal Title: Molecular Endocrinology Volume: 29 Issue: 11 Pages: 1646-1657
  • DOI: 10.1210/me.2015-1125
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Parkin receptor on damaged mitochondria revisited -uncovering the role of phosphorylated ubiquitin chain (2015)
  • Author(s): Matsuda, N. and Tanaka, K.
  • Journal Title: Autophagy Volume: 11 Issue: 9 Pages: 1700-1701
  • DOI: 10.1080/15548627.2015.1071760
  • Peer Reviewed / Open Access
• [Journal Article] Tagged tags engage disposal (2015)
  • Author(s): Matsuda, N. and Tanaka, K.
  • Journal Title: Nature (News and Views) Volume: 524 Issue: 7565 Pages: 294-295
  • DOI: 10.1038/nature15199
  • Peer Reviewed
• [Journal Article] Proteasome Impairment Induces Recovery of Mitochondrial Membrane Potential and an Alternative Pathway of Mitochondrial Fusion (2015)
  • Author(s): Shirozu R, Yashiroda H, Murata S
  • Journal Title: Molecular and Cellular Biology Volume: 36 Issue: 2 Pages: 347-362
  • DOI: 10.1128/mcb.00920-15
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Redundant roles of Rpn10 and Rpn13 in recognition of ubiquitinated proteins and cellular homeostasis. (2015)
  • Author(s): Hamazaki J, Hirayama S, Murata S. Redundant roles of Rpn10 and Rpn13 in recognition of ubiquitinated proteins and cellular homeostasis.
  • Journal Title: PLoS Genet. Volume: 11 Issue: 7 Pages: e1005401-e1005401
  • DOI: 10.1371/journal.pgen.1005401
  • Peer Reviewed / Open Access
• [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells. (2015)
  • Author(s): Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
  • Journal Title: EMBO Rep. Volume: なし Issue: 5 Pages: 638-653
  • DOI: 10.15252/embr.201540096
  • Peer Reviewed
• [Journal Article] Identification of minimum Rpn4-responsive elements in genes related to proteasome functions. Shirozu R, Yashiroda H, *Murata S (2015)
  • Author(s): Shirozu R, Yashiroda H, Murata S
  • Journal Title: FEBS Letter Volume: 589 Issue: 8 Pages: 933-940
  • DOI: 10.1016/j.febslet.2015.02.025
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function. (2015)
  • Author(s): Yashiroda H, Toda Y, Otsu S, Takagi K, Mizushima T, Murata S.
  • Journal Title: Mol Cell Biol Volume: 35(1) Issue: 1 Pages: 141-52
  • DOI: 10.1128/mcb.00582-14
  • Peer Reviewed
• [Journal Article] Sirt1-deficiency causes defective protein quality control (2015)
  • Author(s): Tomita T, Hamazaki J, Hirayama S, McBurney MW, Yashiroda H, Murata S
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 12613-12613
  • DOI: 10.1038/srep12613
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus. (2015)
  • Author(s): Cha, J., Burnum-Johnson, K.E., Bartos, A., Li, Y., Baker, ES., Tilton, S.C., Webb-Robertson, B.J., Piehowski, P.D., Monroe, M.E., Jegga, A.G., Murata, S., Hirota, Y., Dey, S.K.
  • Journal Title: The Journal of Biological Chemistry Volume: 290 Issue: 24 Pages: 15337-15349
  • DOI: 10.1074/jbc.m115.655001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells (2015)
  • Author(s): Katsuhiro Sasakil, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama, Shigeo Murata
  • Journal Title: Nat Commun. in press
  • NAID: 120006999409
  • Description: 印刷中
  • Peer Reviewed
• [Journal Article] The significant role of autophagy in the granular layer in normal skin differentiation and hair growth. (2014)
  • Author(s): Yoshihara, N., Ueno, T., Takagi, A., Trejo, JA., Haruna, K., Suga, Y., Komatsu, M., Tanaka, K., *Ikeda, S.
  • Journal Title: Arch. Dermatol. Res. Volume: 307 Issue: 2 Pages: 159-169
  • DOI: 10.1007/s00403-014-1508-0
  • Peer Reviewed / Open Access
• [Journal Article] Structural Basis for Proteasome Formation Controlled by an Assembly Chaperone Nas2 (2014)
  • Author(s): Satoh T, Saeki Y, Hiromoto T, Wang YH, Uekusa Y, Yagi H, Yoshihara H, Yagi-Utsumi M, Mizushima T, Tanaka K, Kato K
  • Journal Title: Structure Volume: (掲載確定) Issue: 5 Pages: 731-743
  • DOI: 10.1016/j.str.2014.02.014
  • Peer Reviewed
• [Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy. (2014)
  • Author(s): Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
  • Journal Title: Biochem Biophys Res Commun. Volume: 446 Issue: 1 Pages: 309-315
  • DOI: 10.1016/j.bbrc.2014.02.093
  • Peer Reviewed
• [Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. (2014)
  • Author(s): Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Ueno T.
  • Journal Title: Autophagy Volume: 10 Issue: 4 Pages: 631-41
  • DOI: 10.4161/auto.27785
  • Peer Reviewed
• [Journal Article] Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome (2014)
  • Author(s): Pack, CG., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
  • Journal Title: Nature Commun Volume: 5 Issue: 1 Pages: 3396-3396
  • DOI: 10.1038/ncomms4396
  • Peer Reviewed
• [Journal Article] Dissection of the role of p62/Sqstml in activation of Nrf2 during xenophagy. (2014)
  • Author(s): Ishimura, R., Tanaka, K., and Komatsu, M.
  • Journal Title: FEBS Lett. Volume: 588 Issue: 5 Pages: 822-828
  • DOI: 10.1016/j.febslet.2014.01.045
  • Peer Reviewed
• [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin. (2014)
  • Author(s): Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E. A., Trempe, J. F., Saeki, Y., Tanaka, K., and Matsuda, N.
  • Journal Title: Nature Volume: 510(in press) Issue: 7503 Pages: 162-166
  • DOI: 10.1038/nature13392
  • Peer Reviewed
• [Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation (2014)
  • Author(s): Takagi, K., Saeki, Y., Yashiroda, H., Yagi, H., Kaiho, A., Murata, S., Yamane, T., Tanaka, K., Mizushima, T. and Kato, K.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 450 Issue: 2 Pages: 1110-1114
  • DOI: 10.1016/j.bbrc.2014.06.119
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The ESCRT-III adaptor protein Brol controls functions of regulator for free ubiauitin chains 1 (Rful) in ubiquitin homeostasis (2014)
  • Author(s): Kimura Y, Kawawaki J, Kakiyama Y, Shimoda A, and Tanaka K
  • Journal Title: J Biol Chem Volume: 289 Issue: 31 Pages: 21760-21769
  • DOI: 10.1074/jbc.m114.550871
  • Peer Reviewed
• [Journal Article] Backbone 1H, 13C, and 15N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone (2014)
  • Author(s): Y.Uekusa, K.Okawa, M.Yagi-Utsumi, O.Serve, Y. Nakagawa, T.Mizushima, H.Yagi, Y.Saeki, K.Tanaka, and K.Kato
  • Journal Title: Biomol. NMR Assign. Volume: 8 Issue: 2 Pages: 383-386
  • DOI: 10.1007/s12104-013-9523-1
  • Peer Reviewed
• [Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway (2014)
  • Author(s): Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
  • Journal Title: J Biol Chem Volume: 289 Issue: 36 Pages: 24944-24955
  • DOI: 10.1074/jbc.m114.580357
  • Peer Reviewed / Open Access
• [Journal Article] Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. (2014)
  • Author(s): Yoo, HM., Kang, SH., Kim, JY., Lee, JE., Seong, MW., Lee, SW., Ka, SH., Sou,YS., Komatsu, M., Tanaka, K., Lee, ST., Noh, DY., Baek, SH., Jeon, YJ., *Chung, CH.
  • Journal Title: Mol. Cell Volume: 56 Issue: 2 Pages: 261-274
  • DOI: 10.1016/j.molcel.2014.08.007
  • Peer Reviewed
• [Journal Article] Characterization of Testis-Specific Proteasome Subunit α4s in Mammals (2014)
  • Author(s): Hiroyuki Uechi, Jun Hamazaki, and Shigeo Murata
  • Journal Title: The Journal of Biological Chemistry Volume: 289 Issue: 18 Pages: 12365-12374
  • DOI: 10.1074/jbc.m114.558866
  • Peer Reviewed
• [Journal Article] Assembly mechanisms of specialized core particles of the proteasome. (2014)
  • Author(s): Bai M, Zhao X, Sahara K, Ohte Y, Hirano Y, Kaneko T, Yashiroda H, Murata S.
  • Journal Title: Biomolecules. Volume: 4(3) Issue: 3 Pages: 662-77
  • DOI: 10.3390/biom4030662
  • Peer Reviewed / Open Access
• [Journal Article] The mechanism for molecular assembly of the proteasome. (2014)
  • Author(s): Sahara K, Kogleck L, Yashiroda H, Murata S.
  • Journal Title: Adv Biol Regul. Volume: 54 Pages: 51-8
  • DOI: 10.1016/j.jbior.2013.09.010
  • Peer Reviewed
• [Presentation] Phase Separated Proteasome Condensates : For Nuclear Proteolysis (2019)
  • Author(s): Keiji Tanaka
  • Organizer: Joint Annual Meeting of 71st JSCB & 19th PSSJ, Joint Symposium. Emerging concepts of protein science : From nanoscale to cells
  • Int'l Joint Research / Invited
• [Presentation] プロテアソーム～相分離が拓く新しいタンパク質分解機構～ (2019)
  • Author(s): 田中啓二
  • Organizer: 第二回 形態解析ワークショップー 多様な顕微鏡を用いて
  • Invited
• [Presentation] The Proteasome : Stress and Phase Separation (2019)
  • Author(s): Keiji Tanaka
  • Organizer: NIH-Japan-JSPS Symposium : Symposium Theme : Inflammation
  • Int'l Joint Research / Invited
• [Presentation] 細胞内恒常性機能維持機構とがん・老化関連疾患. 「肺線維症における細胞老化の意義と治療的応用」 (2019)
  • Author(s): 田中啓二
  • Organizer: 第4回 肺トランスレーショナルメデイシン研究会
  • Invited
• [Presentation] The Proteasome - Action Mechanisms and Spatiotemporal Dynamics (2019)
  • Author(s): Keiji Tanaka
  • Organizer: Ken-ichi Arai Memorial Symposium
  • Invited
• [Presentation] 蛋白質科学の新常識 : ナノスケールから細胞まで (2019)
  • Author(s): S. Yasuda, H. Tsuchiya, Y. Saeki, and K. Tanaka
  • Organizer: 第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会、合同企画シンポジウム
  • Invited
• [Presentation] How cells respond to proteasome impairment (2019)
  • Author(s): Shigeo Murata
  • Organizer: X-ZOMES Conference 2019
  • Int'l Joint Research / Invited
• [Presentation] Assembly and Spatio-temporal Dynamics (2018)
  • Author(s): Keiji Tanaka
  • Organizer: 24th IUBMB-15th FAOBMB Congress, N. Protein modification and regulation (4) [SY1-1] PTM in Cell Signaling
  • Int'l Joint Research / Invited
• [Presentation] Parkin - Overview. (2018)
  • Author(s): Keiji Tanaka
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society on New Horizon of Neuroscience, “Parkin” 20th anniversary International symposium
  • Int'l Joint Research / Invited
• [Presentation] プロテアソーム～動作原理から生理機能～ (2018)
  • Author(s): 田中啓二
  • Organizer: 新潟大学 医学部 セミナー
  • Invited
• [Presentation] The Proteasome ～Assembly and Spatiotemporal Dynamics～ (2018)
  • Author(s): Keiji Tanaka
  • Organizer: International Symposium on “Proteins : from the Cradle to the Grave”
  • Int'l Joint Research / Invited
• [Presentation] これから科学者を目指す君たちへ (2018)
  • Author(s): 田中啓二
  • Organizer: 秋田大学市民講演会
  • Invited
• [Presentation] The Proteasome ～Structure and Spatiotemporal Dynamics～ (2018)
  • Author(s): Keiji Tanaka
  • Organizer: Asian Pacific Prion Symposium 2018 (APPS2018)
  • Int'l Joint Research / Invited
• [Presentation] プロテアソーム～選択的なタンパク質リサイクルシステム～ (2018)
  • Author(s): 田中啓二
  • Organizer: 自治医科大学大学院医学研究科 開設40周年記念事業
  • Invited
• [Presentation] ユビキチンとプロテアソーム～基礎から医学研究へ～. (2018)
  • Author(s): 田中啓二
  • Organizer: 国立国際医療研究センター研究所(NCGMRI)“冬期リトリート”
  • Invited
• [Presentation] How cells respond to proteasome impairment (2018)
  • Author(s): Shigeo Murata
  • Organizer: 8th workshop on proteasome and autophagy
  • Int'l Joint Research / Invited
• [Presentation] タンパク質分解装置プロテアソームの機能制御機構と病態 (2018)
  • Author(s): 村田茂穂
  • Organizer: 愛媛大学TRCセミナー
  • Invited
• [Presentation] A genome-wide siRNA screen reveals a new ubiquitin binding protein, which exports ubiquitinated proteins from the nucleus (2018)
  • Author(s): Shigeo Murata
  • Organizer: International Symposium on “Proteins : from the Cradle to the Grave”
  • Int'l Joint Research
• [Presentation] プロテアソーム機能調節介入による健康寿命の延長 (2018)
  • Author(s): 村田茂穂
  • Organizer: AMED-CREST/PRIME機能低下・老化プロジェクト合同リトリート
  • Invited
• [Presentation] Role of ubiquitination in nuclear export of proteins (2018)
  • Author(s): 村田茂穂
  • Organizer: 第41回日本分子生物学会年会
  • Invited
• [Presentation] プロテアソームの分子多様性と生理機能の解明 (2018)
  • Author(s): 村田茂穂
  • Organizer: 2018年度持田記念学術賞講演
  • Invited
• [Presentation] プロテアソーム機能低下時の細胞応答機構 (2018)
  • Author(s): 村田茂穂
  • Organizer: 第91回日本生化学会大会
  • Invited
• [Presentation] プロテアソーム ～四半世紀の研究を回想する～ (2018)
  • Author(s): 田中啓二
  • Organizer: 徳島大学 先端酵素学研究所設立記念シンポジウム
  • Invited
• [Presentation] The Proteasome～Structure and Immunological Roles～ (2018)
  • Author(s): Keiji Tanaka
  • Organizer: The XVI International Symposium on Amyloidosis (ISA2018)
  • Int'l Joint Research / Invited
• [Presentation] Cell-mediated Immunity govern by Immunoproteasome and Thymoproteasome, “Ubiquitin Family, Autophagy and Diseases” (2018)
  • Author(s): Keiji Tanaka
  • Organizer: Cold Spring Harbor Asia Conference (CSH Asia)
  • Int'l Joint Research / Invited
• [Presentation] The Proteasome ～Action Mechanisms and Physiology～ (2018)
  • Author(s): Keiji Tanaka
  • Organizer: Advanced Forum on Protein Sciences in Beijing
  • Int'l Joint Research / Invited
• [Presentation] Spatio-temporal Dynamics of Human Proteasomes in Stress Responses (2018)
  • Author(s): Keiji Tanaka
  • Organizer: The 8th Proteasome and Autophagy Workshop
  • Int'l Joint Research / Invited
• [Presentation] How cells respond to proteasome impairment (2018)
  • Author(s): Shigeo Murata
  • Organizer: The proteasome hub : fine tuning of proteolysis according to cellular needs
  • Int'l Joint Research / Invited
• [Presentation] タンパク質分解と生命医科学研究 (2017)
  • Author(s): 田中啓二
  • Organizer: 平成28年度 東京都医師会功労賞表彰式および医学研究賞・グループ研究賞受賞記念講演会
  • Place of Presentation: 東京都医師会館(東京都千代田区)
  • Year and Date: 2017-02-25
  • Invited
• [Presentation] プロテアソームと適応(細胞性)免疫 (2017)
  • Author(s): 田中啓二
  • Organizer: 第14回Osteoimmunology Forum
  • Place of Presentation: ステーションコンファレンス東京(東京都千代田区)
  • Year and Date: 2017-02-11
  • Invited
• [Presentation] プロテアソーム : 多彩な生命活動を支えるタンパク質分解装置のバイオロジー (2017)
  • Author(s): 村田 茂穂
  • Organizer: 高等研プロジェクト「生命活動を生体高分子への修飾から俯瞰する」
  • Place of Presentation: 国際高等研究所(京都府木津川市)
  • Year and Date: 2017-01-23
  • Invited
• [Presentation] 私のプロテアソーム研究 ～幸運と不運の間で～ (2017)
  • Author(s): 田中啓二
  • Organizer: 第44回神戸ラボ全体研究会議
  • Invited
• [Presentation] Emerging Role of Thymoproteasomes in (Adaptive) Immunity. (2017)
  • Author(s): Keiji Tanaka
  • Organizer: Sorak Conference on Protein Metabolism and Degradation
  • Int'l Joint Research / Invited
• [Presentation] プロテアソームを手探りに免疫の世界を楽しむ (2017)
  • Author(s): 田中啓二
  • Organizer: 第19回免疫サマースクール in 湘南
  • Invited
• [Presentation] プロテアソーム と オートファジー (2017)
  • Author(s): 田中啓二
  • Organizer: 第22回日本病態プロテアーゼ学会学術集会 教育講演
  • Invited
• [Presentation] 細胞内リサイクルシステム～ プロテアソーム と オートファジー (2017)
  • Author(s): 田中啓二
  • Organizer: ～製薬コンソ・AMED共催 創薬コンソ分野別研究会
  • Invited
• [Presentation] プロテアソーム～もう一つのタンパク質リサイクルシステム (2017)
  • Author(s): 田中啓二
  • Organizer: ～東工大栄誉教授・大隅良典氏 ノーベル賞受賞記念「七人の侍」講演会
  • Invited
• [Presentation] タンパク質リサイクルシステム～プロテアソーム と オートファジー (2017)
  • Author(s): 田中啓二
  • Organizer: ～ライフサイエンス イノベーション発信セミナー
  • Invited
• [Presentation] プロテアソーム ～基礎研究が未来を拓く～ (2017)
  • Author(s): 田中啓二
  • Organizer: 第1回日本医療研究開発大賞 受賞記念講演
  • Invited
• [Presentation] The Proteasome : Overview of the Structure and Functions (2017)
  • Author(s): 田中啓二
  • Organizer: ConBio2017 Consortium of Biological Sciences 2017
  • Invited
• [Presentation] Activation of Nrfl compensates for proteasome dysfunction (2017)
  • Author(s): Shigeo Murata
  • Organizer: EMBO Conference “Protein quality control : success and failure in health and disease”
  • Int'l Joint Research / Invited
• [Presentation] 半端なベクトルに出口無し!～徹底した基礎研究から広がる応用～「黎明期のプロテアソーム研究」 (2016)
  • Author(s): 田中啓二
  • Organizer: 第39回分子生物学会(MBSJ)年会 プレナリーモーニングセミナー
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-12-02
  • Invited
• [Presentation] Identification of molecules involved in Nrf1 activation in response to proteasome inhibition (2016)
  • Author(s): 村田 茂穂
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-11-30
• [Presentation] Regulation mechanism of proteasome activity (Keynote lecture) (2016)
  • Author(s): Shigeo Murata
  • Organizer: 3rd proteostasis action meeting "Proteostasis and its Biological Implications"
  • Place of Presentation: Lisbon. Portugal
  • Year and Date: 2016-11-02
  • Int'l Joint Research / Invited
• [Presentation] ～タンパク質のゆりかごから墓場まで～「プロテアソーム“自己と非自己”識別の根源に迫る!」 (2016)
  • Author(s): 田中啓二
  • Organizer: 京都産業大学「タンパク質動態研究所」開設記念シンポジウム
  • Place of Presentation: 京都産業大学講堂(京都府京都市)
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] 免疫型プロテアソームによる Antigen processingと“自己と非自己の識別”機構 (2016)
  • Author(s): 田中啓二
  • Organizer: 第25回日本組織適合性学会 : MHC研究の進歩 : 生命科学と臨床医学へのインパクト
  • Place of Presentation: 北海道大学学術交流会館(北海道札幌市)
  • Year and Date: 2016-10-22
  • Invited
• [Presentation] 私のプロテアソーム研究 (2016)
  • Author(s): 田中啓二
  • Organizer: 89回 日本生化学会大会 ～生化学の創造的復興～ Meet the Expert.
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-09-27
  • Invited
• [Presentation] Spatio-temporal Dynamics of the Human Proteasome in Stress Responses (2016)
  • Author(s): Keiji Tanaka
  • Organizer: FASEB “Ubiquitin & Cellular Regulation”
  • Place of Presentation: Big Sky Resort Huntley Lodge 50 Big Sky Resort Road Big Sky MT, USA
  • Year and Date: 2016-06-12
  • Int'l Joint Research / Invited
• [Presentation] Identification of molecules involved in Nrfl activation in response to proteasome inhibition (2016)
  • Author(s): Shigeo Murata, Shun Koizumi, Jun Hamazaki
  • Organizer: FASEB SRC "Ubiquitin & Cellular Regulation"
  • Place of Presentation: Big Sky, Montana, USA
  • Year and Date: 2016-06-12
  • Int'l Joint Research
• [Presentation] Ubiquitin Chain-type. 「Selectivity of Ubiquitin-binding Proteins in Yeast」 (2016)
  • Author(s): Keiji Tanaka
  • Organizer: Ubiquitin Family, Autophagy and Disease. Cold Spring Harbor Asia Conference (CSH Asia)
  • Place of Presentation: Suzhou, China
  • Year and Date: 2016-04-18
  • Int'l Joint Research / Invited
• [Presentation] Regulation mechanism of proteasome activity (2016)
  • Author(s): Shigeo Murata
  • Organizer: Ubiquitin Family, Autophagy and Disease. Cold Spring Harbor Asia Conference (CSH Asia)
  • Place of Presentation: Suzhou, China
  • Year and Date: 2016-04-18
  • Int'l Joint Research / Invited
• [Presentation] Ubiquitin chain-type selectivity of ubiquitin-binding proteins in yeast (2016)
  • Author(s): Keiji Tanaka
  • Organizer: Ubiquitin Family, Autophagy and Diseases Cold Spring Harbor Asia Conference (CSH Asia)
  • Place of Presentation: Suzhou, China
  • Year and Date: 2016-04-18
  • Int'l Joint Research / Invited
• [Presentation] Regulatory mechanism of the proteasome (2016)
  • Author(s): Shigeo Murata
  • Organizer: Ubiquitin Family, Autophagy and Diseases Cold Spring Harbor Asia Conference (CSH Asia)
  • Place of Presentation: Suzhou, China
  • Year and Date: 2016-04-18
  • Int'l Joint Research / Invited
• [Presentation] “変わる徳島大学” : 「研究と教育 ～組織改革への期待～」 (2016)
  • Author(s): 田中啓二
  • Organizer: 学部新設・改組及び新研究所設置記念式典・記念講演会
  • Place of Presentation: 徳島グランヴィリオホール(徳島県徳島市)
  • Year and Date: 2016-04-11
  • Invited
• [Presentation] 研究と教育～組織改革への期待～ (2016)
  • Author(s): 田中啓二
  • Organizer: 「変わる徳島大学」学部新設・改組及び新研究所設置記念式典・記念講演会
  • Place of Presentation: 徳島グランヴィリオホテル・グランヴィリオホール(徳島県徳島市)
  • Year and Date: 2016-04-11
  • Invited
• [Presentation] Thymoproteasome : The Key Player in Positive Selection of CD8+ T cells (2016)
  • Author(s): Keiji Tanaka
  • Organizer: The 7th Proteasome and Autophagy Workshop
  • Place of Presentation: Clermont-Ferrand, France
  • Year and Date: 2016-04-06
  • Int'l Joint Research / Invited
• [Presentation] 私のブロテアソーム研究～幸運と不運に彩られて～ (2016)
  • Author(s): 田中啓二
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま(福島県郡山市)
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] ブロテアソームの多様性と生体制御 (2016)
  • Author(s): 村田茂穂
  • Organizer: 第32回高峰カンファレンス
  • Place of Presentation: 如水会館(東京都千代田区)
  • Year and Date: 2016-03-11
  • Invited
• [Presentation] ブロテアソームの多様性による生体制御 (2016)
  • Author(s): 村田茂穂
  • Organizer: 第4回CAKIカンファレンス
  • Place of Presentation: リーガロイヤルホテル広島(広島県広島市)
  • Year and Date: 2016-01-09
  • Invited
• [Presentation] Regulation mechanisms of the proteasome (2016)
  • Author(s): Shigeo Murata
  • Organizer: Ubiquitin international symposium "Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond"
  • Place of Presentation: 京都大学(京都府京都市)
  • Int'l Joint Research / Invited
• [Presentation] In-depth Analyses of Thymoproteasomes -Positive Selection of CD8+ T cells- (2015)
  • Author(s): Keiji Tanaka
  • Organizer: Ubiquitin and Ubiquitin-like modifiers : From molecular mechanisms and human diseases (2nd EMBO Ubiquitin Conference Series)
  • Place of Presentation: I Cavtat, Croatia
  • Year and Date: 2015-09-18
  • Int'l Joint Research / Invited
• [Presentation] タンパク質分解～辺境領域から生命科学の中枢へ～ (2015)
  • Author(s): 田中啓二
  • Organizer: 国立医薬品食品衛生研究所 講演
  • Place of Presentation: 国立医薬品食品衛生研究所(東京都世田谷区)
  • Year and Date: 2015-09-04
  • Invited
• [Presentation] Ubiquitin : lst Mitophagy driven by PINKI, Parkin and Ubiquitin, 2nd MS and TR-Tube Strategy for Ubiquitin Code Analysis (2015)
  • Author(s): Keiji Tanaka
  • Organizer: The 2nd Ubiquitin Symposium at Hotel Stefani e
  • Place of Presentation: Vienna Biocenter, Austria
  • Year and Date: 2015-07-10
  • Int'l Joint Research / Invited
• [Presentation] Basic Mechanisms and Physiopathology of The Proteasome (2015)
  • Author(s): Keiji Tanaka
  • Organizer: IMP (Research Institute of Molecular Pathology) Lecture
  • Place of Presentation: Vienna Biocenter, Austria
  • Year and Date: 2015-07-09
  • Int'l Joint Research / Invited
• [Presentation] ブロテアソームの多様性と生体制御 (2015)
  • Author(s): 村田茂穂
  • Organizer: 第7回免疫適塾
  • Place of Presentation: スターツ総合研修センター(茨城県つくばみらい市)
  • Year and Date: 2015-07-05
  • Invited
• [Presentation] 栄養学における基礎科学と応用科学の統合 (2015)
  • Author(s): 田中啓二
  • Organizer: 徳島大学栄養学科同窓会(栄友会)東日本支部(文化功労者顕彰記念)同窓会セミナー
  • Place of Presentation: 昭和女子大学(東京都世田谷区)
  • Year and Date: 2015-06-27
  • Invited
• [Presentation] 「細胞内の蛋白質の一生 : 新生から死に至るまで」 : タンバク質分解装置“ブロテアソーム”の動態と作動機構 (2015)
  • Author(s): 田中啓二
  • Organizer: 第15回 日本蛋白質科学会 年会シンポジウム
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] 胸腺ブロテアソームによるT細胞正の選択の新しい機構 (2015)
  • Author(s): 村田茂穂
  • Organizer: 平成27年度日本生化学会関東支部例会
  • Place of Presentation: 新潟日報メディアシップ(新潟県新潟市)
  • Year and Date: 2015-06-20
  • Invited
• [Presentation] Ubiquitin Phosphorylation : a missing link between activation and recruitment of Parkin for mitophagy (2015)
  • Author(s): Keiji Tanaka
  • Organizer: The 7th International Symposium on Autophagy
  • Place of Presentation: Huangshan, China
  • Year and Date: 2015-03-19 – 2015-03-23
  • Invited
• [Presentation] 栄養学における基礎科学と応用科学の統合 (2015)
  • Author(s): 田中啓二
  • Organizer: 日本栄養士会・研究教育事業部・全国研修会の基調講演
  • Place of Presentation: 東京農業大学、東京都世田谷区
  • Year and Date: 2015-03-07
  • Invited
• [Presentation] タンパク質分解～辺境領域から生命科学の中枢へ～ (2015)
  • Author(s): 田中啓二
  • Organizer: 第8回「酵素学研究拠点」シンポジウム : タンパク質代謝・分解系の酵素学「文化功労者」顕彰記念講演
  • Place of Presentation: 徳島大学藤井節郎記念ホール、徳島県徳島市
  • Year and Date: 2015-02-10
  • Invited
• [Presentation] 私のフロテアソーム研究～成功と失敗のエピソード～ (2014)
  • Author(s): 田中啓二
  • Organizer: 国立国際医療研究センター研究所セミナー
  • Place of Presentation: 国立国際医療研究センター、東京都新宿区
  • Year and Date: 2014-12-08
  • Invited
• [Presentation] 私のプロテアソーム研究～成功と失敗のエピソード～ (2014)
  • Author(s): 田中啓二
  • Organizer: 新学術領域「ユビキチンネオバイオロジー」領域班会議 -文化功労者 -顕彰記念講演
  • Place of Presentation: ホテルたつき、愛知県蒲郡市
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] Proteasome Dynamics and Physiopathology focusing on Immunity (2014)
  • Author(s): Keiji Tanaka
  • Organizer: ZOMES VIII Conference-From systems dynamics to biology
  • Place of Presentation: Xiamen Grand Hotel, Xiamen, China
  • Year and Date: 2014-11-18 – 2014-11-21
  • Invited
• [Presentation] オートファジーの破綻によるミトコンドリアストレスと肝癌・神経変性疾患 (2014)
  • Author(s): 田中啓二
  • Organizer: 第9回臨床ストレス応答学会大会特別講演
  • Place of Presentation: 岡山大学鹿田キャンパス内マスカットキューブ、岡山県岡山市
  • Year and Date: 2014-11-02 – 2014-11-03
  • Invited
• [Presentation] ミスフォールドタンパク質の細胞内動態制御機構 (2014)
  • Author(s): 村田茂穂
  • Organizer: 第9回臨床ストレス応答学会
  • Place of Presentation: 岡山大学、岡山県岡山市
  • Year and Date: 2014-11-02
  • Invited
• [Presentation] Rpn13 and Rpn10 coordinately play a role in degradation of ubiquitinated protein in mice (2014)
  • Author(s): Shigeo Murata
  • Organizer: EMBO-CONICET ubiquitin conference 2014 "Ubiquitin & ubiquitin-like proteins : At the crossroads from chromatin to protein"
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2014-10-22
  • Invited
• [Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System (2014)
  • Author(s): Keiji Tanaka
  • Organizer: EMBO Conference Ubiquitin & Ubiquitin-like Proteins : At the crossroads from chromatin to protein
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2014-10-19 – 2014-10-24
  • Invited
• [Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System (2014)
  • Author(s): Keiji Tanaka
  • Organizer: The 87th Annual Meeting of the Japanese Biochemical Society New Phase in Organelle Biology : Cellular Organellostasis with Mitochondria as a Hub
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2014-10-15
  • Invited
• [Presentation] Basic Mechanisms and Physiopathological Roles of Eukaryotic Proteasomes (2014)
  • Author(s): Keiji Tanaka
  • Organizer: Nobel Forum Lecture
  • Place of Presentation: Karolinska Institute, Stockholm, SWEDEN
  • Year and Date: 2014-09-18
  • Invited
• [Presentation] 神経変性疾患の謎を解く-タンパク分解系からのアフローチー- (2014)
  • Author(s): 田中啓二
  • Organizer: 第37回日本神経科学大会(Neuroscience 2014)「神経科学が世界を変える」教育講演
  • Place of Presentation: パシフィコ横浜, 神奈川県横浜市
  • Year and Date: 2014-09-13
  • Invited
• [Presentation] 生化学の立場から～タンパク質の新陳代謝～ (2014)
  • Author(s): 田中啓二
  • Organizer: 第61回日本栄養改善学会学術集会「栄養学-新たな挑戦日本栄養改善学会60周年シンポジウム」
  • Place of Presentation: パシフィコ横浜、神奈川県横浜市
  • Year and Date: 2014-08-21
  • Invited
• [Presentation] プロテアソームの制御による生体調節 (2014)
  • Author(s): 村田茂穂
  • Organizer: 第19回日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター、大阪府豊中市
  • Year and Date: 2014-08-09
  • Invited
• [Presentation] 私のプロテアソーム研究～偶然が必然を誘う幸運～ (2014)
  • Author(s): 田中啓二
  • Organizer: 免疫サマースクール
  • Place of Presentation: オリビアン小豆島、香川県小豆島
  • Year and Date: 2014-07-29
  • Invited
• [Presentation] The PINK1-Parkin Pathway Controls Mitochondrial Homeostasis Whose Collapse Causes Parkinson's Disease (2014)
  • Author(s): Keiji Tanaka
  • Organizer: International Conference on Protein Metabolism and Diseases
  • Place of Presentation: SolBeach Hotel & Resort, Yangyang, Korea
  • Year and Date: 2014-07-09 – 2014-07-11
  • Invited
• [Presentation] 「プロテアソーム」動作原理から炎症・免疫疾患制御への展望 (2014)
  • Author(s): 田中啓二
  • Organizer: 第35回日本炎症・再生医学会Think Different教育講演
  • Place of Presentation: 万国津梁館、沖縄県名護市
  • Year and Date: 2014-07-01 – 2014-07-04
  • Invited
• [Presentation] タンパク質の新陳代謝～健康と病気のみなもと～ (2014)
  • Author(s): 田中啓二
  • Organizer: 「サイエンステクノフロンティアフォーラム」サイテックサロン
  • Place of Presentation: 駒場ファカルティハウス(東京大学駒場キャンパス内)、東京都目黒区
  • Year and Date: 2014-06-28
  • Invited
• [Presentation] The Proteasome : Basic Mechanisms and The Immunological Roles (2014)
  • Author(s): Keiji Tanaka
  • Organizer: CBSM2014-Yonsei BK21plus Joint symposium
  • Place of Presentation: Yonsei Univ. (Seoul) & Gunja Village(Andong), Korea
  • Year and Date: 2014-06-19 – 2014-06-21
  • Invited
• [Presentation] Thymoproteasome generates unique peptides that elicit positive selection of developing T cells (2014)
  • Author(s): Shigeo Murata
  • Organizer: Cold Spring Harbor Asia Symposium "Protein Modification & Homeostasis"
  • Place of Presentation: Suzhou, China
  • Year and Date: 2014-06-17
  • Invited
• [Presentation] 私のプロテアソーム研究を回想して (2014)
  • Author(s): 田中啓二
  • Organizer: 第66回日本細胞生物学会 : 七人の侍たちからのメッセージ～私の仕事を通じて若者達に伝えたきこと～Mol Cell (preview)
  • Place of Presentation: 奈良県新公会堂・東大寺総合文化センター、奈良県奈良市
  • Year and Date: 2014-06-11 – 2014-06-13
  • Invited
• [Presentation] The PINK1-Parkin System Controls Mitochondrial Homeostasis to Suppress The Cause of Parkinson's Disease (2014)
  • Author(s): Keiji Tanaka
  • Organizer: The KSU International Symposium on Cutting-Edge of Life Sciences
  • Place of Presentation: Musubiwaza-hall at Mibu Campus of KSU, Kyoto
  • Year and Date: 2014-05-30 – 2014-05-31
  • Invited
• [Book] 「構造生命科学からトランススケール・イメージングによる細胞動態学へ」実験医学増刊号 (2020)
  • Author(s): 田中啓二、若槻壮市(編集)
  • Total Pages: 240
  • Publisher: 羊土社
• [Book] Ubiquitin chain elongation : An intriguing strategy. Mol Cell (preview) (2014)
  • Author(s): Iwai, K. and Tanaka, K.
  • Total Pages: 3
  • Publisher: Cell Press
• [Book] FROM EAST TO WEST : Pioneers in Parkinson's disease in Japan-A historical overview of major achievement in research (2014)
  • Author(s): Tanaka, K.
  • Total Pages: 2
  • Publisher: QOL laboratory Corp
• [Remarks] 公益財団法人東京都医学総合研究所 蛋白質代謝研究室
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks] 東京大学大学院薬学系研究科 蛋白質代謝学教室
  • URL: http://www.f.u-tokyo.ac.jp/~tanpaku/
• [Remarks]
  • URL: http://www.f.u-tokyo.ac.jp/~tanpaku/
• [Remarks]
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks]
  • URL: http://www.f.u-tokyo.ac.jp/~tanpaku/
• [Remarks]
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks] 研究代表者 : 田中啓二(蛋白質代謝研究室)
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks] ユビキチンプロジェクト
  • URL: http://www.igakuken.or.jp/project/detail/ubiquitin.html
• [Remarks] 研究分担者 : 村田茂穂
  • URL: http://www.f.u-tokyo.ac.jp/~tanpaku/
• [Patent(Industrial Property Rights)] ポリユビキチン化基質の同定方法 (2014)
  • Inventor(s): 吉田雪子、佐伯泰、土屋光、村上有沙、田中啓二
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Filing Date: 2014-11-13