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Single-Molecule Sequencing Methods via Tunneling Current

Research Project

Project/Area Number 26220603
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Nanomaterials chemistry
Research InstitutionOsaka University

Principal Investigator

Taniguchi Masateru  大阪大学, 産業科学研究所, 教授 (40362628)

Research Collaborator TSUTSUI Makusu  
OHSHIRO Takahito  
YOKOTA Kazumichi  
KOMOTO Yuki  
Project Period (FY) 2014-05-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥177,710,000 (Direct Cost: ¥136,700,000、Indirect Cost: ¥41,010,000)
Fiscal Year 2018: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2017: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2016: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2015: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2014: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Keywords1分子科学 / 量子シークエンサー / DNA / RNA / ペプチド / 1分子シークエンシング / トンネル電流 / ナノギャップ電極
Outline of Final Research Achievements

In this study, we successfully concatenated the base molecules in DNA and RNA and the partial amino acid sequence of peptide and sequenced the entire genome of a virus by measuring the tunneling current flowing through a single molecule. We successfully observed the direct incorporation of our target anticancer drug into DNA and identified the individual molecules associated with the chemically modified base molecule and the amino acid, both of which are vital disease markers. A quantitative method was developed to analyze the base sequences and abundance ratios for the two types of DNA and RNA contained in the target solution. We determined the amino acid sequences and the abundance ratios for the two types of peptides under investigation.

Academic Significance and Societal Importance of the Research Achievements

1分子シークエンシング法は、現在の技術では直接解読できない、RNAの塩基配列やペプチドのアミノ酸配列を直接決定できるため、新たな生命現象の解明に寄与すると期待される。さらに、安価で高速にゲノム配列を決定できる本手法は、ゲノム解析に基づく個別化医療に寄与すると期待される。また、DNA中のがんマーカーや抗がん剤を直接観察できる本手法は、抗がん剤の作用機序を調べ、新たな抗がん剤の開発に寄与すると期待される。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(10 results)
  • 2019 Research Progress Assessment (Verification Result) ( PDF )
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Abstract ( PDF )   Annual Research Report
  • Research Products

    (112 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (7 results) Journal Article (26 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 25 results,  Open Access: 14 results,  Acknowledgement Compliant: 5 results) Presentation (66 results) (of which Int'l Joint Research: 17 results,  Invited: 44 results) Book (3 results) Remarks (4 results) Patent(Industrial Property Rights) (5 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Massachusetts Institute of Technology/Harvard Medical School(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of California, San Diego(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Single-Molecule Science and Technology(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of California, San Diego(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Huazhong University of Sci. & Tech.(中国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of California(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Huazhong University of Sci. and Tech.(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution2019

    • Author(s)
      Ohshiro Takahito、Komoto Yuuki、Konno Masamitsu、Koseki Jun、Asai Ayumu、Ishii Hideshi、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3886-3886

    • DOI

      10.1038/s41598-019-40504-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atomically flat platinum films grown on synthetic mica2018

    • Author(s)
      Tanaka Hiroyuki、Taniguchi Masateru
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 4 Pages: 048001-048001

    • DOI

      10.7567/jjap.57.048001

    • NAID

      210000148846

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Evaluation of Dielectric Breakdown of Silicon Micro- and Nanofluidic Devices for Electrophoretic Transport of a Single DNA Molecule2018

    • Author(s)
      Sano Mamiko、Kaji Noritada、Wu Qiong、Naito Toyohiro、Yasui Takao、Taniguchi Masateru、Kawai Tomoji、Baba Yoshinobu
    • Journal Title

      Micromachines

      Volume: 9 Issue: 4 Pages: 180-180

    • DOI

      10.3390/mi9040180

    • NAID

      120006510291

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrical Nucleotide Sensor Based on Synthetic Guanine‐Receptor‐Modified Electrodes2018

    • Author(s)
      Takahito Ohshiro、Rajiv Kumar Verma、Kazumichi Yokota、Makusu Tsutsui、Sanjukta Mukherjee、Tomoji Kawai、Kazuhiko Nakatani、Masateru Taniguchi
    • Journal Title

      Chemistry Select

      Volume: 3 Issue: 13 Pages: 3819-3824

    • DOI

      10.1002/slct.201702341

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Remote heat dissipation in atom-sized contacts2018

    • Author(s)
      Tsutsui Makusu、Morikawa Takanori、Yokota Kazumichi、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1

    • DOI

      10.1038/s41598-018-26203-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring Single-Molecule Conductance at An Ultra-Low Molecular Concentration in Vacuum2018

    • Author(s)
      Liu Bo、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      Micromachines

      Volume: 9 Issue: 6 Pages: 282-282

    • DOI

      10.3390/mi9060282

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative analysis of DNA with single-molecule sequencing2018

    • Author(s)
      Ohshiro Takahito、Tsutsui Makusu、Yokota Kazumichi、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1

    • DOI

      10.1038/s41598-018-26875-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast and low-noise tunnelling current measurements for single-molecule detections in electrolyte solution using insulator-protected nanoelectrodes2017

    • Author(s)
      Takanori Morikawa, Kazumichi Yokota, Makusu Tsutsui, and Masateru Taniguchi
    • Journal Title

      Nanoscale

      Volume: 9 Issue: 12 Pages: 4076-4081

    • DOI

      10.1039/c6nr09278k

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short channel effects on electrokinetic energy conversion in solid-state nanopores2017

    • Author(s)
      Zhang Yan、He Yuhui、Tsutsui Makusu、Miao Xiang Shui、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/srep46661

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detecting Single-Nucleotides by Tunneling Current Measurements at Sub-MHz Temporal Resolution2017

    • Author(s)
      Takanori Morikawa, Kazumichi Yokota, Sachie Tanimoto, Makusu Tsutsui, Masateru Taniguchi
    • Journal Title

      Sensors

      Volume: 17 Issue: 4 Pages: 885-885

    • DOI

      10.3390/s17040885

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrokinetic Analysis of Energy Harvest from Natural Salt Gradients in Nanochannels2017

    • Author(s)
      He Yuhui、Huang Zhuo、Chen Bowei、Tsutsui Makusu、Shui Miao Xiang、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-13336-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of membrane surface charges on the ion transport in MoS2 nanopore power generators2017

    • Author(s)
      Huang Zhuo、Zhang Yan、Hayashida Tomoki、Ji Ziwei、He Yuhui、Tsutsui Makusu、Miao Xiang Shui、Taniguchi Masateru
    • Journal Title

      Applied Physics Letters

      Volume: 111 Issue: 26

    • DOI

      10.1063/1.5003695

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Single-Molecule Analysis Methods Using Nanogap Electrodes and Their Application to DNA Sequencing Technologies2017

    • Author(s)
      Taniguchi Masateru
    • Journal Title

      Bulletin of The Chemical Society of Japan

      Volume: 90 Issue: 11 Pages: 1189-1210

    • DOI

      10.1246/bcsj.20170224

    • NAID

      130006201449

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid structural analysis of nanomaterials in aqueous solutions2017

    • Author(s)
      Sou Ryuzaki, Makusu Tsutsui, Yuhui He, Kazumichi Yokota, Akihide Arima, Takanori Morikawa, Masateru Taniguchi and Tomoji Kawai
    • Journal Title

      Nanotechnology

      Volume: 28 Issue: 11 Pages: 115004-115004

    • DOI

      10.1063/1.4967214

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dipole effects on the formation of molecular junctions2016

    • Author(s)
      Sachie Tanimoto, Makusu Tsutsui, Kazumichi Yokota, and Masateru Taniguchi
    • Journal Title

      Nanoscale Horizons

      Volume: 1 Issue: 5 Pages: 399-406

    • DOI

      10.1039/c6nh00088f

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 66.Salt-gradient approach for regulating capture-to-translocation dynamics of DNA with nanochannel sensors2016

    • Author(s)
      Yuhui He, Makusu Tsutsui, Ralph Scheicher, Xiang Shui Miao, and Masateru Taniguchi
    • Journal Title

      ACS Sensors

      Volume: 1 Issue: 6 Pages: 807-816

    • DOI

      10.1021/acssensors.6b00176

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 化学と生物2016

    • Author(s)
      谷口正輝
    • Journal Title

      1分子シークエンサーの現状と可能性

      Volume: 54 Pages: 396-402

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 現代化学2016

    • Author(s)
      谷口正輝
    • Journal Title

      1分子DNAシークエンシング技術とその応用

      Volume: 547 Pages: 52-55

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decoding DNA, RNA and Peptides with Quantum Tunnelling2016

    • Author(s)
      Massimiliano Di Ventra, Masateru Taniguchi
    • Journal Title

      Nature Nanotechnology

      Volume: 11 Issue: 2 Pages: 117-126

    • DOI

      10.1038/nnano.2015.320

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Impact of Water-Depletion Layer on Transport in Hydrophobic Nanochannels2015

    • Author(s)
      Yuhui He, Makusu Tsutsui, Xiang Shui Miao, Masateru Taniguchi
    • Journal Title

      Analytical Chemistry

      Volume: 87(24) Issue: 24 Pages: 12040-12050

    • DOI

      10.1021/acs.analchem.5b03061

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Selective Multidetection Using Nanopores2015

    • Author(s)
      Masateru Taniguchi
    • Journal Title

      Analytical Chemistry

      Volume: 87(1) Issue: 1 Pages: 188-199

    • DOI

      10.1021/ac504186m

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 1分子シークエンサー ~DNA・RNA・ペプチドの解読~2015

    • Author(s)
      谷口正輝
    • Journal Title

      生命化学レター

      Volume: 47 Pages: 9-14

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Detection of post-translational modifications in single peptides using electron tunneling currents2014

    • Author(s)
      大城敬人、筒井真楠、横田一道、古橋匡幸、谷口正輝、川合知二
    • Journal Title

      Nature Nanotechnology

      Volume: 9 Issue: 10 Pages: 835-835

    • DOI

      10.1038/nnano.2014.193

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discrimination of equi-sized nanoparticles by surface charge state using low-aspect-ratio pore sensors2014

    • Author(s)
      有馬彰秀、筒井真楠、谷口正輝
    • Journal Title

      Applied Physics Letters

      Volume: 104 Issue: 16 Pages: 163112-163112

    • DOI

      10.1063/1.4873681

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thermoelectric Voltage Measurements of Atomic and Molecular Wires Using Microheater-Embedded Mechanically-Controllable Break Junctions2014

    • Author(s)
      Takanori Morikawa, Akihide Arima, Makusu Tsutsui and Masateru Taniguchi
    • Journal Title

      Nanoscale

      Volume: 6 Issue: 14 Pages: 8235-8241

    • DOI

      10.1039/c4nr00127c

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Graphene/hexagonal boron nitride/graphene nanopore for electrical detection of single molecules2014

    • Author(s)
      Yuhui He, Makusu Tsutsui, Sou Ryuzaki, Kazumichi Yokota, Masateru Taniguchi and Tomoji Kawai
    • Journal Title

      NPG Asia Materials

      Volume: 6 Issue: 6 Pages: e104-e104

    • DOI

      10.1038/am.2014.29

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 機械学習と1分子解析 技術の融合によるマルチオミックス解析2019

    • Author(s)
      谷口 正輝
    • Organizer
      大阪大学産業科学研究所・東京大学生産技術研究所 研究交流会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 1分子計測で抗がん剤の作用機序を調べる2019

    • Author(s)
      谷口 正輝
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] MCBJ法を用いたDNAシーケンシングによる連続塩基数識別法の開発2019

    • Author(s)
      小本祐貴、大城敬人、谷口正輝
    • Organizer
      2019年第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] トンネル電流計測1分子検出法を用いた化学修飾を含む核酸塩基鎖識別法の開発2019

    • Author(s)
      大城敬人、小本祐貴、浅井歩、今野雅允、石井秀始、谷口正輝
    • Organizer
      2019年第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Smart Biosensing Technologies2018

    • Author(s)
      Masateru Taniguchi
    • Organizer
      7th imec Handai International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子量子シークエンシング2018

    • Author(s)
      谷口 正輝
    • Organizer
      2018年第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] バイオデバイスの基盤技術と開発~1つの遺伝子・ウイルス・細菌を識別する技術~2018

    • Author(s)
      谷口 正輝
    • Organizer
      バイオ&ナノ・マイクロデバイス実践セミナー~微細加工技術のバイオ分野への応用に向けて~
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヘルステックにおける非連続イノベーション2018

    • Author(s)
      谷口 正輝
    • Organizer
      第1回COI学会 1st COI Conference
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] スマートバイオデバイス2018

    • Author(s)
      谷口 正輝
    • Organizer
      第 5回電子デバイスフォーラム 京都プログラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 微小信号計測とAI で拓くスマートバイオセンサー2018

    • Author(s)
      谷口 正輝
    • Organizer
      日本工学アカデミー講演会 次世代マテリアルシステム~超微小信号計測の汎用化により”Well-Being 2050”を導く~
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 1分子量子シークエンサーの医療応用2018

    • Author(s)
      谷口 正輝
    • Organizer
      第38回 キャピラリー電気泳動シンポジウム (SCE2018)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] トンネル電流計測1分子の核酸塩基種の機械学習識別法の開発2018

    • Author(s)
      大城敬人、鷹合孝之、吉田剛、小本祐貴、鷲尾隆、谷口正輝
    • Organizer
      2018年第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 極微電流計測が拓くバイオデバイス2018

    • Author(s)
      谷口正輝
    • Organizer
      第4回プリンテッドエレクトロニクス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 機械学習と1分子解析技術の融合2018

    • Author(s)
      谷口正輝、鷲尾隆、川合知二
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 械学習と1分子シークエンシング法の融合2018

    • Author(s)
      谷口正輝
    • Organizer
      日本化学会第97春季年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 核酸塩基プローブをもちいた核酸塩基鎖識別法の開発2018

    • Author(s)
      大城敬人
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DNAシーケンシングに向けた核酸塩基種別のための単分子高精度解析法の開発2018

    • Author(s)
      大城敬人
    • Organizer
      日本化学会第97春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of Single-Molecule Electrophoretic Control Method for Single-Molecule Tunnel-Current based Nucleotide Identification by Nano-fluid integrated Nano-gap Devices2018

    • Author(s)
      Takahito Ohshiro
    • Organizer
      APS Spring 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Single-Molecule Analysis Methods Using Nanogap Electrodes and Their Application to DNA Sequencing Technology2017

    • Author(s)
      Masateru Taniguchi
    • Organizer
      日本化学会 第97春季年会(2017)
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Smart Biosensing Technologies to Detect Single Bacteria and Viruses2017

    • Author(s)
      Masateru Taniguchi
    • Organizer
      EDTM 2017(Electron Devices Technology and Manufacturing Congerence)
    • Place of Presentation
      Toyama International Conference Center(富山県富山市)
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Single-Molecule Sequencing Technology2017

    • Author(s)
      Masateru Taniguchi
    • Organizer
      International Workshop on Life Detection Technology: For Mars, Enceladus and Beyond
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Single-Molecule Electrical Sequencing2017

    • Author(s)
      Masateru Taniguchi
    • Organizer
      Japanese-German Workshop, Single-Molecule Science and Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノポア集積デバイスによる分離・検出法の創成に向けて2017

    • Author(s)
      大城敬人
    • Organizer
      第77回分析化学討論会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 機械学習を用いた1修飾塩基分子識別2017

    • Author(s)
      大城敬人
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機械学習を用いた1塩基識別2017

    • Author(s)
      谷口正輝
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 人工核酸塩基識別のためのトンネル電流計測法の開発2017

    • Author(s)
      大城敬人
    • Organizer
      日本分析学会第66回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of Single-Molecule Detection and Translocation Control by Electrophoresis of Nano-fluid Toward Biopolymer Sequencing2017

    • Author(s)
      Takahito Ohshiro
    • Organizer
      MicroTAS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-Molecule Electrical Sequencing of DNA, RNA, and Peptide2016

    • Author(s)
      Masateru Taniguchi
    • Organizer
      Japan-Spain Joint Workshop on Nanomedicine Research
    • Place of Presentation
      スペイン
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 次々世代 DNA シーケンサの開発2016

    • Author(s)
      谷口 正輝
    • Organizer
      第36回キャピラリー電気泳動シンポジウム(SCE2016)
    • Place of Presentation
      徳島大学常三島キャンパス工業会館(徳島県徳島市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ナノポアデバイスと機械学習の融合による1細菌・1ウイルス検出2016

    • Author(s)
      谷口 正輝
    • Organizer
      MNC 2016 技術セミナー「マイクロ・ナノバイオ技術の最前線」
    • Place of Presentation
      ANA Crowne Plaza Kyoto(京都府京都市)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノポアを用いた1個の細菌・ウイルスの検出2016

    • Author(s)
      谷口 正輝
    • Organizer
      第2回 四国オープンイノベーションワークショップ in 松山~オープンイノベーションによる四国地域の産業活性化を目指して~
    • Place of Presentation
      にぎたつ会館(愛媛県松山市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] トンネル電流を用いた1分子解析技術2016

    • Author(s)
      谷口 正輝
    • Organizer
      理研シンポジウム: 第4回「光量子工学研究 -若手・中堅研究者から見た光量子工学の展開-」
    • Place of Presentation
      理化学研究所(埼玉県和光市)
    • Year and Date
      2016-10-31
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 日本の技術力でゲノム競争を巻き返す2016

    • Author(s)
      谷口 正輝
    • Organizer
      第105回 岡山県医用工学研究会 平成27年度 第2回セミナー・交流会 最新バイオ・ナノテクノロジーの応用展開
    • Place of Presentation
      岡山大学鹿田キャンパス(岡山県・岡山市)
    • Year and Date
      2016-10-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Nanogap Sequencing of Biopolymers2016

    • Author(s)
      Masateru Taniguchi
    • Organizer
      Asia NANO 2016
    • Place of Presentation
      Sapporo Convention Center(北海道札幌市)
    • Year and Date
      2016-10-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子の電気伝導度を用いる1分子シークエンシング技術2016

    • Author(s)
      谷口 正輝
    • Organizer
      第89回日本生化学会大会 in 仙台
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Single-molecule Identification of Biopolymers2016

    • Author(s)
      Masateru Taniguchi
    • Organizer
      International Symposium on Polymer and Related Materials
    • Place of Presentation
      ハルビン工程大学(中華人民共和国)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nanogap Sequencing for Personalized Medicine and Therapeutics2016

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 14th International Nanotech Symposium & Nano-Convergence Expo(NANO KOREA 2016)
    • Place of Presentation
      KINTEX(韓国)
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子DNAシークエンサーが生み出すビッグデータ2016

    • Author(s)
      谷口正輝、川合知二、筒井真楠、横田一道、鷲尾隆
    • Organizer
      2016年度人工知能学会全国大会(第30回)(JSAI 2016)
    • Place of Presentation
      北九州国際会議場/西日本総合展示場新館・本館(福岡県福岡市)
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA、RNA、ペプチドの1分子シークエンシング法2016

    • Author(s)
      谷口 正輝
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Decoding biological information with quantum chemistry2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Acquiring biological information of DNA, RNA, and peptide2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 14th SANKEN Nanotechnology International Symposium, ISIR, Osaka University 他合同シンポジウム
    • Place of Presentation
      大阪大学 銀杏会館(大阪府・吹田市)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子ペプチドシークエンサー2015

    • Author(s)
      谷口 正輝
    • Organizer
      新アミノ酸分析研究会」第5回学術講演会プログラム
    • Place of Presentation
      東京大学武田先端知ビル(東京都・文京区)
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Single-molecule electrical sequencing technique2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 16th RIES-Hokudai International Symposium
    • Place of Presentation
      Chateraise Gateaux Kingdom Sapporo(北海道・札幌市)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Single-molecule Sequencing Technology To Identify Sequences Of Base Molecules In DNA And RNA And Sequences Of Amino Acid Molecules In Peptides2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      5th Annual Next Generation Sequencing Asia Congress and co-located 3rd Annual Single Cell Analysis Asia Congress
    • Place of Presentation
      Singapore(Republic of Singapore)
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Single molecule sequencing of DNA, RNA, and peptide2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Acquiring Biological Information of Individuals Using Quantum Mechanics2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      2015 International Conference on Solid State Devices and Materials(SSDM 2015)
    • Place of Presentation
      Sapporo Convention Center(北海道・札幌市)
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] トンネル電流によるDNA・RNA・ペプチドの1 分子識別2015

    • Author(s)
      谷口 正輝
    • Organizer
      バイオ・高分子研究会 バイオ高分子を科学する
    • Place of Presentation
      秋保温泉 ホテルニュー水戸屋(宮城県・仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] トンネル電流を用いる1分子DNA・RNA・ペプチドシークエンサーの開発2015

    • Author(s)
      谷口 正輝
    • Organizer
      NGS Field 4th Meeting
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Single Molecule Technologies to Identify the Central Dogma2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      3rd Core to Core Program Conference /4th imec Handai International Symposium
    • Place of Presentation
      Eindhoven(The Netherlands)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オーダーメード医療につながる1分子シークエンシング2015

    • Author(s)
      谷口 正輝
    • Organizer
      科学技術・学術政策研究所「近未来への招待状 ~ナイスステップな研究者2014からのメッセージ~」
    • Place of Presentation
      文部科学省 科学技術・学術政策研究所(東京都・千代田区)
    • Year and Date
      2015-06-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ナノ接合の熱起電力2015

    • Author(s)
      谷口正輝
    • Organizer
      日本化学会 第95春季年会 (2015)
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部(千葉県船橋市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アミノ酸・ペプチド識別にむけたトンネル電流単分子電流計測法の開発2015

    • Author(s)
      大城敬人、筒井真楠、横田一道、谷口正輝
    • Organizer
      日本化学会 第95春季年会(2015)
    • Place of Presentation
      日本大学 理工学部船橋キャンパス/薬学部(千葉県船橋市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 複数ナノ間隙デバイスを用いた単分子計測法の開発2015

    • Author(s)
      大城敬人、筒井真楠、横田一道、谷口正輝
    • Organizer
      第62回応用物理学会春季学術講演会
    • Place of Presentation
      東海大学 湘南キャンパス(神奈川県平塚市)
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single Molecule Electrical Sequencing Technology2015

    • Author(s)
      Masateru Taniguchi
    • Organizer
      PITTCON 2015 CONFERENCE & EXPO
    • Place of Presentation
      Ernest N. Morial Convention Center(U.S.A.)
    • Year and Date
      2015-03-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Single-Molecule DNA, RNA, and Peptide Sequencing Technologies2014

    • Author(s)
      Masateru TANIGUCHI
    • Organizer
      2nd Conference of SANKEN Core to Core 3rd imec Handai International Symposium (2nd Symposium of SANKEN BrainCirculation Program)
    • Place of Presentation
      Knowledge Capital Congres Convention Center(Osaka Japan)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of a Single Molecular Tunnel-Current Identification Method for Electrical Genome Sequencing2014

    • Author(s)
      Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi
    • Organizer
      2014 MRS Fall Meeting & Exhibit
    • Place of Presentation
      Hynes Convention Center and Sheraton Boston Hotel(U.S.A.)
    • Year and Date
      2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single-molecule electrical sequencing of biomolecules2014

    • Author(s)
      Masateru Taniguchi
    • Organizer
      7th International Workshop on Advanced Materials Science and Nanotechnology, IWAMSN 2014
    • Place of Presentation
      Grand Ha Long Hotel(Ha Long City, Vietnam)
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of Single-Molecule Tunnel-Current based Identification Method by Using Metal Nano -Gap Structures2014

    • Author(s)
      Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi
    • Organizer
      The 7th International Symposium on Surface Science (ISSS-7)
    • Place of Presentation
      Shimane Prefectural Convention Center, Kunibiki Messe(Matsue, Shimane)
    • Year and Date
      2014-11-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] SINGLE-MOLECULE SEQUENCING TECHNOLOGIES OF BIOMOLECULES VIA ELECTRIC CURRENTS2014

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Henry B. Gonzalez Convention Center(U.S.A.)
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] DEVELOPMENT OF A SINGLE-MOLECULE ELECTRICAL NUCLEOTIDE IDENTIFICATION METHOD TOWARD A CELL TRANSCRIPTOME ANALYSIS2014

    • Author(s)
      Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi
    • Organizer
      The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Henry B. Gonzalez Convention Center(U.S.A.)
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生体高分子の1分子解析2014

    • Author(s)
      谷口 正輝
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎大学 文教キャンパス(長崎県長崎市)
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 単分子電気検出のためのシリコン基板デバイスの開発2014

    • Author(s)
      大城敬人、筒井真楠、横田一道、川合知二、谷口正輝
    • Organizer
      第75回応用物理学会秋季学術講演会
    • Place of Presentation
      北海道大学 札幌キャンパス(北海道札幌市)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] トンネル電流計測に基づくアミノ酸識別法の開発2014

    • Author(s)
      大城 敬人、川合 知二、谷口 正輝
    • Organizer
      日本分析化学会 第63年会
    • Place of Presentation
      広島大学 東広島キャンパス(広島県東広島市)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single-Molecule Tunnel-Current based Detection Toward Amino-Acid Identification2014

    • Author(s)
      Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi
    • Organizer
      2014 International Conference on Solid State Devices and Materials (SSDM2014)
    • Place of Presentation
      つくば国際会議場(茨城県つくば市
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single Molecular Technologies to Identify Central Dogma2014

    • Author(s)
      Masateru Taniguchi
    • Organizer
      The 6th IEEE International Nanoelectronics Conference 2014 (IEEE INEC 2014)
    • Place of Presentation
      Hokkaido University Conference Hall (Sapporo, Hollaido)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Developmenl 01 Single-Molecule Tunnel・Currentbased Nucleolide idenl師cationMelho2014

    • Author(s)
      Takahito Ohshiro, Makusu Tsutsi, Kazumichi Yokota, Tomji Kawai, Masateru Taniguch
    • Organizer
      The 6th IEEE International Nanoelectronics Conference 2014 (IEEE INEC 2014)
    • Place of Presentation
      Hokkaido University Conference Hall (Sapporo, Hollaido)
    • Year and Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
  • [Book] 分子アーキテクトニクス2018

    • Author(s)
      浅井美博、夛田博一、谷口正輝、寺尾潤、西原寛
    • Total Pages
      201
    • Publisher
      化学同人
    • ISBN
      9784759813913
    • Related Report
      2018 Annual Research Report
  • [Book] Nanofluidcs: Edition 22016

    • Author(s)
      Y. He, M. Tsutsui, and M. Taniguchi
    • Total Pages
      40
    • Publisher
      Royal Society of Chemistry
    • Related Report
      2016 Annual Research Report
  • [Book] Single-Molecule Electronics2016

    • Author(s)
      M. Taniguchi
    • Total Pages
      19
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究室のホームページ

    • URL

      http://bionano.sanken.osaka-u.ac.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 谷口研究室ホームページ

    • URL

      http://www.bionano.sanken.osaka-u.ac.jp/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.bionano.sanken.osaka-u.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 谷口研究室のホームページ

    • URL

      http://www.bionano.sanken.osaka-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 電極基板2018

    • Inventor(s)
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Holder
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 電極調整方法および電極調整装置2018

    • Inventor(s)
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Holder
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 修飾RNAバイオマーカーによる精密診断法2018

    • Inventor(s)
      谷口正輝、石井秀始、大城敬人、今野雅充
    • Industrial Property Rights Holder
      谷口正輝、石井秀始、大城敬人、今野雅充
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 基板2017

    • Inventor(s)
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Holder
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 絶縁材上の金属線切断法2017

    • Inventor(s)
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Holder
      谷口正輝、大城敬人、真田雅和、宮城聡
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] Japanese-German Workshop, Single-Molecule Science and Technology2017

    • Related Report
      2017 Annual Research Report

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Published: 2014-06-05   Modified: 2022-04-28  

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