Deepening and Developing New Aspects of Flash Chemistry

• Project/Area Number: 26220804
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry
• Research Institution: Suzuka National College of Technology (2018-2019); Kyoto University (2014-2017)
• Principal Investigator: YOSHIDA Jun-ichi 鈴鹿工業高等専門学校, 校長 (30127170)
• Co-Investigator(Kenkyū-buntansha): Nagaki Aiichiro 京都大学, 大学院工学研究科, 准教授 (80452275) ; Simizu Akihiro 京都大学, 大学院工学研究科, 助教 (30584263) ; Tonomura Osamu 京都大学, 大学院工学研究科, 助教 (70402956) ; Suga Seiji 岡山大学, 自然科学研究科, 教授 (50291430)
• Co-Investigator(Renkei-kenkyūsha): Kim Heejin 京都大学, 大学院工学研究科, 特定助教 (80754514)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥192,010,000 (Direct Cost: ¥147,700,000、Indirect Cost: ¥44,310,000); Fiscal Year 2018: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000); Fiscal Year 2017: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000); Fiscal Year 2016: ¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000); Fiscal Year 2015: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000); Fiscal Year 2014: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
• Keywords: 有機合成 / 反応設計 / フラッシュケミストリー / マイクロリアクター / フローケミストリー / ファインケミカル / フローマイクロリアクター / ハイスループット合成 / 有機活性種 / 活性種 / 高分子合成 / 体系化 / ハイスルーブット合成

Outline of Final Research Achievements

In this project, we deepened the concept of flash chemistry, which is a chemical synthesis using extremely fast reactions (seconds to milliseconds order) based on flow chemistry and developed new applications in organic synthesis by rational design of reactions based on the quantitative analysis using temperature-residencetime mapping and kinetic studies.

Academic Significance and Societal Importance of the Research Achievements

これまでの研究成果の多くはすでにScience誌など世界的に著名な学術誌に発表され、高い学術的価値を認められている。研究成果は国内の新聞報道だけでなく国際的な学術誌のハイライトにも掲載されており、関連学問分野における世界的なインパクトの大きさがうかがえる。さらに、「フロー・マイクロ合成国際会議」を開催し、参加者238名、海外招待講演者8名、国内招待講演者9名、ポスター発表37件、展示企業16社を集めるなど社会に大きなインパクトを与えた。また、フラッシュケミストリーの概念に基づいた化学品の製造も富士フイルムグループなどですでに始まっている。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Int'l Joint Research] University of Poitiers(France)
• [Int'l Joint Research] POSTECH/Pukyong National University(韓国)
• [Int'l Joint Research] University of Paris South(France)
• [Int'l Joint Research] University of Mainz(Germany)
• [Int'l Joint Research] Philipps-Universität Marburg(Germany)
• [Int'l Joint Research] Pohang Univ. of Sci. & Tech.(韓国)
• [Journal Article] 1.Alkyllithiums Bearing Electrophilic Functional Groups: A Flash Chemistry Approach. (2019)
  • Author(s): Nagaki, A.; Yamashita, H.; Hirose, K.; Tsuchihashi, Y.; Yoshida, J.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 58 Issue: 12 Pages: 40274030-40274030
  • DOI: 10.1002/anie.201814088
  • Peer Reviewed / Open Access
• [Journal Article] Fast Micromixing Enables Selective Reactions with One of Several Same Functional Groups. (2018)
  • Author(s): Nagaki, A.; Yamashita, H.; Ishiuchi, S.; Takahashi, Y.; Imai, K.; Toshinari, K; Furusawa, M.; Yoshida, J.
  • Journal Title: Chem. Lett Volume: 47 Issue: 1 Pages: 71-73
  • DOI: 10.1246/cl.170899
  • NAID: 130006302083
  • Peer Reviewed / Open Access
• [Journal Article] A Catalyst-Free Amination of Functional Organolithium Reagents by Flow Chemistry (2018)
  • Author(s): Heejin Kim, Yuya Yonekura, Jun-ichi Yoshida
  • Journal Title: Angew. Chem. Int. Ed. Volume: 57 Issue: 15 Pages: 4063-4066
  • DOI: 10.1002/anie.201713031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sequential double C-H functionalization of 2,5-norbornadiene in flow (2018)
  • Author(s): Kim Heejin、Yin Zuoyufan、Sakurai Hidehiro、Yoshida Jun-ichi
  • Journal Title: Reaction Chemistry & Engineering Volume: 3 Issue: 5 Pages: 635-639
  • DOI: 10.1039/c8re00131f
  • Peer Reviewed
• [Journal Article] Metal- and Oxidant-Free Alkenyl C-H/Aromatic C-H Cross-Coupling Using Electrochemically Generated Iodosulfonium Ions. (2018)
  • Author(s): Hayashi, R.; Shimizu, A.; Daives, J. A.; Ishizaki, Y.; Willis, C.; Yoshida, J.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 57 Issue: 39 Pages: 1289112895-1289112895
  • DOI: 10.1002/anie.201807592
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Control of Tandem Isomerizations: Flow-Assisted Reactions of o-Lithiated Aryl Benzyl Ethers (2017)
  • Author(s): Hyune-Jea Lee, Heejin Kim, Jun-ichi Yoshida, Dong-Pyo Kim
  • Journal Title: Chem. Commun. Volume: 54 Issue: 5 Pages: 547-550
  • DOI: 10.1039/c7cc08460a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Harnessing [1,4]-, [1,5]-, and [1,6]-Anionic Fries-type Rearrangements by Reaction Time Control in Flow. (2017)
  • Author(s): Kim, H.; Inoue, K.; Yoshida, J.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 56 Issue: 27 Pages: 78637866-78637866
  • DOI: 10.1002/anie.201704006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Micromixing Enables Chemoselective Reactions of Difunctional Electrophiles with Functional Aryllithiums. (2017)
  • Author(s): Nagaki, A.; Ishiuchi, S.; Imai, K.; Sasatsuki, K.; Nakahara, Y.; Yoshida, J.
  • Journal Title: React. Chem. Eng. Volume: 2 Issue: 6 Pages: 862-870
  • DOI: 10.1039/c7re00142h
  • Peer Reviewed / Open Access
• [Journal Article] Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow (2017)
  • Author(s): Ichinari Daisuke、Nagaki Aiichiro、Yoshida Jun-ichi
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 25 Issue: 23 Pages: 6224-6228
  • DOI: 10.1016/j.bmc.2017.07.005
  • Peer Reviewed / Open Access
• [Journal Article] "Impossible" Chemistries Based on Flow and Micro. (2017)
  • Author(s): Yoshida, J.; Kim, H.; Nagaki, A.
  • Journal Title: J. Flow Chem Volume: 7 Issue: 3-4 Pages: 60-64
  • DOI: 10.1556/1846.2017.00017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New Approach to 1,4-Benzoxazin-3-ones by Electrochemical C,H-Amination. (2017)
  • Author(s): Wesenberg, L. J.; Herold, S.; Shimizu, A.; Yoshida, J.; Waldvogel, S. R.
  • Journal Title: Chem. Eur. J. Volume: 23 Issue: 50 Pages: 1209612099-1209612099
  • DOI: 10.1002/chem.201701979
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsaltan (2016)
  • Author(s): Aiichiro Nagaki, Katsuyuki Hirose, Osamu Tonomura, Satoshi Taniguchi, Toshiki Taga, Shinji Hasebe, Norio Ishizuka, and Jun-ichi Yoshida
  • Journal Title: Org. Process Res. Dev. Volume: 20 Issue: 3 Pages: 687-691
  • DOI: 10.1021/acs.oprd.5b00414
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized -Ketoamides (2016)
  • Author(s): Aiichiro Nagaki, Yusuke Takahashi, and Jun-ichi Yoshida
  • Journal Title: Angew. Chem., Int. Ed. Volume: 55 Issue: 17 Pages: 5327-5331
  • DOI: 10.1002/anie.201601386
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Generation, Characterization, and Reactions of Thionium Ions Based on the Indirect Cation Pool Method (2016)
  • Author(s): Akihiro Shimizu, Keiji Takeda, Shota Mishima, Kodai Saito, Songhee Kim, Toshiki Nokami, Jun-ichi Yoshida*
  • Journal Title: Bull. Chem. Soc. Jpn. Volume: 89 Issue: 1 Pages: 61-66
  • DOI: 10.1246/bcsj.20150323
  • NAID: 130005119459
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Flash cationic polymerization followed by bis-end-functionalization. A new approach to linear-dendritic hybrid polymers. (2016)
  • Author(s): Tani, Y.; Takumi, M.; Moronaga, S.; Nagaki, A.; Yoshida, J.-i.
  • Journal Title: European Polymer Journal Volume: 79 Pages: 227-233
  • DOI: 10.1016/j.eurpolymj.2016.02.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Integration of borylation of aryllithiums and Suzuki–Miyaura coupling using monolithic Pd catalyst (2016)
  • Author(s): Aiichiro Nagaki, Katsuyuki Hirose, Yuya Moriwaki, Koji Mitamura, Kimihiro Matsukawa, Norio Ishizuka, Jun-ichi Yoshida, J.
  • Journal Title: Catal. Sci. Tech Volume: in press Issue: 13 Pages: 0-0
  • DOI: 10.1039/c5cy02098k
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing. (2016)
  • Author(s): Kim, H.; Min, K.-I.; Inoue, K.; Im, D. J.; Kim, D.-P.; Yoshida, J.
  • Journal Title: Science Volume: 352 Issue: 6286 Pages: 691-694
  • DOI: 10.1126/science.aaf1389
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Stabilized Cation Pool Method: Metal- and Oxidant-Free Benzylic C－H/Aromatic C－H Cross-Coupling. (2016)
  • Author(s): Hayashi, R.; Shimizu, A.; Yoshida, J.
  • Journal Title: J. Am. Chem. Soc. Volume: 138 Issue: 27 Pages: 8400-8403
  • DOI: 10.1021/jacs.6b05273
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Switching Between Intermolecular and Intramolecular Reactions Using Flow Microreactors. Lithiation of 2-Bromo-2'-Silylbiphenyls (2016)
  • Author(s): Nagaki, A.*; Kim, S.; Miuchi, N.; Yamashita, H.; Hirose, K.; Yoshida, J.*
  • Journal Title: Org. Chem. Front. Volume: 3 Issue: 10 Pages: 1250-1253
  • DOI: 10.1039/c6qo00257a
  • Peer Reviewed
• [Journal Article] Feasibility Study on Continuous Flow Controlled/Living Anionic Polymerization Processes (2016)
  • Author(s): Nagaki, A.*; Nakahara, Y.; Furusawa, M.; Sawaki, T.; Yamamoto, T.; Toukairin, H.; Tadokoro, S.; Shimazaki, T.; Ito, T.; Otake, M.; Arai, H.; Higashida, N.; Takahashi, Y.; Moriwaki, Y.; Tsuchihashi, Y.; Hirose, K.; Yoshida, J.*
  • Journal Title: Org. Process Res. Dev. Volume: 20 Issue: 7 Pages: 1377-1382
  • DOI: 10.1021/acs.oprd.6b00158
  • Peer Reviewed
• [Journal Article] Preparation and Use of Organolithium and Organomagnesium Species in Flow. (2016)
  • Author(s): Nagaki, A.; Yoshida, J.
  • Journal Title: Top Organomet. Chem. Volume: 57 Pages: 137-176
• [Journal Article] Remarkable Chemoselectivity by Flash Chemistry. Reactions of Difunctional Electrophiles with Functionalized Aryllithiums (2015)
  • Author(s): Nagaki, A.; Imai, K.; Ishiuchi, S.; Yoshida, J.
  • Journal Title: Angew. Chem., Int. Ed. Volume: 54 Issue: 6 Pages: 1914-1918
  • DOI: 10.1002/anie.201410717
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Organolithiums Bearing Aldehyde Carbonyl Groups. A Flash Chemistry Approach (2015)
  • Author(s): Aiichiro Nagaki, Yuta Tsuchihashi, Suguru Haraki and Jun-ichi Yoshida
  • Journal Title: Org. Biomol. Chem Volume: 13 Issue: 26 Pages: 7140-7145
  • DOI: 10.1039/c5ob00958h
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Polymerization of vinyl ethers initiated by dendritic cations using flow microreactors. (2015)
  • Author(s): Nagaki, A.; Takumi M.; Tani, Y.; Yoshida, J.
  • Journal Title: Tetrahedron Volume: 71 Pages: 59735978-59735978
  • NAID: 120005674615
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterocyclization Approach for Electrooxidative Coupling of Functional Primary Alkylamines with Aromatics (2015)
  • Author(s): Tatsuya Morofuji, Akihiro Shimizu, Jun-ichi Yoshida
  • Journal Title: Journal of American Chemical Society Volume: 137 Issue: 31 Pages: 9816-9819
  • DOI: 10.1021/jacs.5b06526
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Low temperature in situ Raman spectroscopy of an electro-generated arylbis(arylthio)sulfonium ion (2015)
  • Author(s): Matsumoto, K.; Miyamoto, Y.; Shimada, K.; Morisawa, Y.; Zipse, H.; Suga, S.; Yoshida, J.; Kashimura, S.; Wakabayashi, T.
  • Journal Title: Chem. Commun. Volume: 51 Issue: 66 Pages: 13106-13109
  • DOI: 10.1039/c5cc03585f
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Electrochemical selenium- and iodonium-initiated cyclisation of hydroxy-functionalised 1,4-dienes. (2015)
  • Author(s): Röse1, P.; Emge, S.; Yoshida, J.; Hilt, G.
  • Journal Title: Beilstein J. Org. Chem. Volume: 11 Pages: 174183-174183
  • DOI: 10.3762/bjoc.11.18
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reaction Integration Using Electrogenerated Cationic Intermediates (2015)
  • Author(s): J. Yoshida, A. Shimizu, Y. Ashikari, T. Morofuji, R. Hayashi, T. Nokami, A. Nagaki
  • Journal Title: Bulletin of the Chemical Society of Japan Volume: 88 Issue: 6 Pages: 763-775
  • DOI: 10.1246/bcsj.20150100
  • NAID: 130005075675
  • ISSN: 0009-2673, 1348-0634
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Flash Generation of α-(Trifluoromethyl)vinyllithium and Application to Continuous Flow Three-Component Synthesis of -Trifluoromethylamides (2014)
  • Author(s): Nagaki, A.; Tokuoka, S.; Yoshida, J.
  • Journal Title: Chem. Commun. Volume: 50 Issue: 95 Pages: 15079-15081
  • DOI: 10.1039/c4cc06709f
  • Peer Reviewed
• [Journal Article] Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles (2014)
  • Author(s): Nagaki, A.; Ichinari, D.; Yoshida, J.
  • Journal Title: J. Am. Chem. Soc. Volume: 136 Issue: 35 Pages: 12245-12248
  • DOI: 10.1021/ja5071762
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Flow Microreactor Synthesis of Fluorine-Containing Block Copolymers (2014)
  • Author(s): Nagaki, A.; Akahori, K.; Takahashi, Y.; Yoshida, J.
  • Journal Title: J. Flow Chem. Volume: 4 Issue: 4 Pages: 168-172
  • DOI: 10.1556/jfc-d-14-00017
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Flash Chemistry Makes It Possible for Intermolecular Reactions to Outpace Intramolecular Reactions. (2018)
  • Author(s): Jun-ichi Yoshida
  • Organizer: 13th International Symposium on Organic Reactions
  • Int'l Joint Research / Invited
• [Presentation] C-H Functionalization by Electrochemistry. (2018)
  • Author(s): Jun-ichi Yoshida
  • Organizer: the 13th International Symposium on Activation of Dioxygen and Homogeneous Oxidation Catalysis
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry: Flow Synthesis That Cannot Be Done in Batch. (2018)
  • Author(s): Jun-ichi Yoshida
  • Organizer: Flow Chemistry Europe 2018
  • Int'l Joint Research / Invited
• [Presentation] 触媒担持モノリス充填カラムを用いた並列反応システムの開発：閉塞診断機能を有する流体分配器の最適設計 (2017)
  • Author(s): 殿村修
  • Organizer: 日本化学会 第97春季年会
  • Place of Presentation: 東京、日本
  • Year and Date: 2017-03-16
• [Presentation] Development of Functional Materials and Reactions Based on Open-Shell π-Conjugated Species (2017)
  • Author(s): Akihiro.Shmizu
  • Organizer: 日本化学会 第97回春季年会（2017）
  • Place of Presentation: 東京、日本
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling (2017)
  • Author(s): A.Nagaki
  • Organizer: International Conference on Catalysis and Chemical Engineering (CCE-2017)
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2017-02-22
  • Int'l Joint Research / Invited
• [Presentation] New Strategies and Tactics in Electroorganic Synthesis: Electroauxiliary, Cation Pool, and Flow Microreactor. (2017)
  • Author(s): Jun-ichi Yoshida
  • Organizer: 12th National Conference on Physical Organic Chemistry, China
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry Makes It Possible for Intermolecular Reactions to Outpace Intramolecular Reactions (2017)
  • Author(s): Jun-ichi Yoshida
  • Organizer: Beilstein Organic Chemistry Symposium
  • Int'l Joint Research / Invited
• [Presentation] The Stabilized Cation Pool Method (2017)
  • Author(s): Jun-ichi Yoshida
  • Organizer: 7th German-Japanese Symposium on Electrosynthesis
  • Int'l Joint Research / Invited
• [Presentation] Recent Advances in Electrochemical C-H Functionalization (2017)
  • Author(s): Jun-ichi Yoshida
  • Organizer: 68th Annual Meeting of the International Society of Electrochemistry
  • Invited
• [Presentation] Development of Flow Distributors with Three-dimensional Channel Structure: Towards Mass Production in Micro Plants (2017)
  • Author(s): Osamu Tonomura,
  • Organizer: POSTECH-Kyoto University-Tsinghua University Joint Student Workshop on Microreactor
  • Place of Presentation: Pohang, Korea
  • Int'l Joint Research
• [Presentation] Bimolecular Reactions Outpace Unimolecular Reactions by Flash Chemistry (2016)
  • Author(s): J. Yoshida
  • Organizer: The 10th International Symposium on Integrated Synthesis
  • Place of Presentation: Awaji Yumebutai, Hyogo, Japan
  • Year and Date: 2016-11-18
  • Int'l Joint Research / Invited
• [Presentation] Anionic Polymerizations Using Flow Microreactors (2016)
  • Author(s): A.Nagaki
  • Organizer: Polymer Chemistry 2016 International Conference,
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry as a Green Technology for Chemical Synthesis. (2016)
  • Author(s): J. Yoshida
  • Organizer: 14th International Conference on Miroreaction Technology
  • Place of Presentation: Beijing, China
  • Year and Date: 2016-09-12
  • Int'l Joint Research / Invited
• [Presentation] Synthesis of Organofluorine Compounds Using Flow Microreactors」 (2016)
  • Author(s): A.Nagaki
  • Organizer: 2nd World Chemistry Conference,
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-08-08
  • Int'l Joint Research / Invited
• [Presentation] 充填層型コンパクトリアクタ内の気液流動様式推定 (2016)
  • Author(s): 殿村修
  • Organizer: 日本プロセス化学会2016サマーシンポジウム
  • Place of Presentation: 名古屋、日本
  • Year and Date: 2016-07-28
• [Presentation] Organolithium Chemistry Using Flow Microreactors to Green Chemistry (2016)
  • Author(s): A.Nagaki
  • Organizer: 7th Annual Global Congress of Catalysis 2016,
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2016-06-30
  • Int'l Joint Research / Invited
• [Presentation] 活性種の電子状態の制御に基づく電子移動反応と有機電池材料の開発 (2016)
  • Author(s): 清水章弘
  • Organizer: 第40回有機電子移動化学討論会
  • Place of Presentation: 神奈川、日本
  • Year and Date: 2016-06-23
  • Invited
• [Presentation] Flash Chemistry: Flash Flow Microreactors Enable Chemical Synthesis That Cannot Be Done in Batch. (2016)
  • Author(s): J. Yoshida
  • Organizer: the 4th Zing Continuous Flow Chemistry Conference
  • Place of Presentation: Albufeira, Portugal
  • Year and Date: 2016-04-25
  • Int'l Joint Research / Invited
• [Presentation] Remarkable Chemoselectivity by Flash Chemistry」 (2016)
  • Author(s): A.Nagaki
  • Organizer: The 12th International Symposium on Organic Reactions (ISOR-12),
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-04-22
  • Int'l Joint Research
• [Presentation] Organolithium Chemistry Using Flow Microreactors (2016)
  • Author(s): A.Nagaki
  • Organizer: International Nanotechnology Conference & Expo (Nanotech-2016 Conference),
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-04-04
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry: organic synthesis that cannot be done in batch. (2016)
  • Author(s): Yoshida, J.
  • Organizer: The 1st International Symposium on Middle Molecular Strategy
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-02-06
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry: an Innovation in the Way of Chemical Synthesis (2016)
  • Author(s): J. Yoshida
  • Organizer: Life Science Lecture
  • Place of Presentation: Bayer, Berlin, Germany
  • Invited
• [Presentation] Flash Chemistry: Organic Synthesis That Cannot Be Done in Batch (2016)
  • Author(s): J. Yoshida
  • Organizer: GDCH Lecture
  • Place of Presentation: Bayer, Wuppertal, Germany
  • Invited
• [Presentation] Flash Chemistry Using Short-lived Organolithium Species (2015)
  • Author(s): Yoshida, J.
  • Organizer: Pacifichem 2015 S-block Metal Chemistry
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-19
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry as a Green Technique for Chemical Synthesis (2015)
  • Author(s): Yoshida, J.
  • Organizer: Pacifichem 2015 New Green Techniques for Medicinal Chemistry
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-19
  • Int'l Joint Research
• [Presentation] Electrogeneration, Characterization, and Reactions of Cationic Organosulfur Intermediates in Organic Synthesis (2015)
  • Author(s): Yoshida, J.
  • Organizer: Pacifichem 2015 New Organosulfur Chemistry
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-17
  • Int'l Joint Research / Invited
• [Presentation] Generation and Reactions of Fluorine-Substituted Organolithiums Based on Flash Chemistry (2015)
  • Author(s): Yoshida, J.
  • Organizer: 21st International Symposium on Fluorine Chemistry ＆International Symposium on Fluorous Technologies 2015
  • Place of Presentation: Como, Italy
  • Year and Date: 2015-08-23
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry Using Flow Microreactors for Synthesis and Production of Chemicals and Drugs (2015)
  • Author(s): Yoshida, J.
  • Organizer: International Forum on MicroManufacturing & Biofabrication’15 (IFMM’15 & IFBF’15) Application of Micro-Nano Technology to Pharma-Medical and Manufacturing Industries
  • Place of Presentation: Toyama, Japan
  • Year and Date: 2015-05-18
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry: Departure from Flask Chemistry (2015)
  • Author(s): Yoshida, J.
  • Organizer: 1st Kyoto University - UC San Diego Joint Symposium
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-03-11
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry: organic synthesis that cannot be done in batch (2015)
  • Author(s): Yoshida, J.
  • Organizer: Kyoto University SGU-CH 1stInternational Workshop -Micro/Flow Chemistry & Engineering
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-01-28
  • Int'l Joint Research / Invited
• [Presentation] Flash Chemistry: organic synthesis that cannot be done in batch (2014)
  • Author(s): Yoshida, J.
  • Organizer: Screen School 2014
  • Place of Presentation: Anglet, France
  • Year and Date: 2014-10-21
  • Int'l Joint Research / Invited
• [Presentation] New Strategies in Electroorganic Synthesis: Reaction Integration Using Electrogenerated Cationic Intermediates (2014)
  • Author(s): Yoshida, J.
  • Organizer: Electrochemistry 2014
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2014-09-22
  • Int'l Joint Research / Invited
• [Book] Science of Synthesis: Flow Chemistry in Organic Synthesis (2018)
  • Author(s): Kim, H.; Yoshida, J
  • Total Pages: 20
  • Publisher: Thieme
• [Book] Basics of Flow Microreactor Synthesis (2015)
  • Author(s): Yoshida, J.
  • Total Pages: 108
  • Publisher: Springer
• [Remarks] 吉田研究室
  • URL: http://www.sbchem.kyoto-u.ac.jp/yoshida-lab/
• [Remarks] 京都大学マイクロ化学生産研究コンソーシアム
  • URL: http://www.cheme.kyoto-u.ac.jp/7koza/mcpsc/
• [Remarks] 京都大学大学院工学研究科 合成・生物化学専攻 吉田研究室
  • URL: http://www.sbchem.kyoto-u.ac.jp/yoshida-lab/
• [Remarks] 京都大学大学院工学研究科 合成・生物化学専攻 吉田研究室
  • URL: http://www.sbchem.kyoto-u.ac.jp/yoshida-lab
• [Funded Workshop] The First International Conference on Automated Flow and Microreactor Synthesis (2018)
• [Funded Workshop] The First International Conference on Automated Flow and Microreactor Synthesis (2018)