| Budget Amount *help |
¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000)
Fiscal Year 2018: ¥34,710,000 (Direct Cost: ¥26,700,000、Indirect Cost: ¥8,010,000)
Fiscal Year 2017: ¥34,710,000 (Direct Cost: ¥26,700,000、Indirect Cost: ¥8,010,000)
Fiscal Year 2016: ¥34,710,000 (Direct Cost: ¥26,700,000、Indirect Cost: ¥8,010,000)
Fiscal Year 2015: ¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2014: ¥54,210,000 (Direct Cost: ¥41,700,000、Indirect Cost: ¥12,510,000)
|
|---|
| Outline of Final Research Achievements |
We have developed the synaptic probe (AS-probe) that can label and erase the labeled dendritic spines by blue laser irradiation. Using AS-probe, we have operationally shown the involvement of spines in motor learning in the motor cortex (Nature 2015) and anti-depressant effects of spine generations in the prefrontal cortex by s-ketamine (Science 2019). We are extending our technique to presynaptic boutons (in preparation). We also studied the cellular mechanisms of the reward classical conditioning, and found that the spine enlargement of D1 neurons can explain the reward timing found in earlier works (Science 2014). We have also clarified that discrimination learning involves spine enlargement of D2 neurons, and is impaired in psychotic symptoms which can be ameliorated by D2 antagonist (an antipsychotic drug), pointing to a new understanding of D2 receptors (in preparations).
|
