| Budget Amount *help |
¥166,920,000 (Direct Cost: ¥128,400,000、Indirect Cost: ¥38,520,000)
Fiscal Year 2018: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
Fiscal Year 2017: ¥37,830,000 (Direct Cost: ¥29,100,000、Indirect Cost: ¥8,730,000)
Fiscal Year 2016: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2015: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Outline of Final Research Achievements |
To elucidate the information pathways from the associative centers that integrate sensory information to the centers of descending neurons that control behaviors, we analyzed comprehensively the brain regions in between, which have hardly been investigated before. Using Drosophila as a model, we performed a very large-scale screening of expression driver strains and identified 890 types of neurons. We found complex pathways from the output of associative centers via dorsal and lateral brain regions to behavior control centers. We revealed the entire pathway of the last one of the five sensory modalities that remained unknown, from somatosensory cells on the body surface to the brain. We also developed an automated system for counting the synaptic sites and revealed cell type- and brain region-specific changes. We finally performed imaging and neuron activation/blocking experiments to identify various neurons from sensory to motor centers that are associated with specific behaviors.
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