| Budget Amount *help |
¥101,010,000 (Direct Cost: ¥77,700,000、Indirect Cost: ¥23,310,000)
Fiscal Year 2018: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2017: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2016: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2014: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Outline of Final Research Achievements |
During this research project period, we focused on elucidation of the mechanisms of coordinated regulation of reproduction and sexual behavior by peptidergic neurons, which is performed by taking advantage of the unique small medaka fish brain model systems and by using multidisciplinary techniques such as transgenic, molecular biological, electrophysiological, anatomical, and neuroethological approaches. 1) High frequency firing activity of hypophysiotropic gonadotropin-releasing hormone (GnRH) 1 neurons triggers gonadotropic hormones (LH) from the pituitary, which then triggers ovulation. 2) We have found novel functions of hypothalamic peptidergic neurons, called kisspeptin neurons, which have been shown to play essential roles in the control of mammalian reproduction. 3) We found that GnRH3 neurons, which produce peptides paralogous to GnRH1, of juvenile medaka show burst-firing activities and are involved in completely novel functions in the brains of juvenile medaka.
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