Co-Investigator(Kenkyū-buntansha) |
上田 善弘 京都大学, 化学研究所, 助教 (90751959)
森崎 一宏 京都大学, 化学研究所, 助教 (80822965)
古田 巧 京都大学, 化学研究所, 准教授 (30336656)
吉田 圭佑 京都大学, 化学研究所, 特定助教 (20709779)
吉村 智之 京都大学, 化学研究所, 助教 (20432320)
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Budget Amount *help |
¥121,680,000 (Direct Cost: ¥93,600,000、Indirect Cost: ¥28,080,000)
Fiscal Year 2018: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2017: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2016: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2015: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
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Outline of Final Research Achievements |
Methods for stereoselective glycosylation using unprotected glucose and site-selective introduction of acyl groups onto a particular hydroxy group of carbohydrates have been developed. These new methods enabled extremely short total synthesis of natural glycosides. Methods for remote asymmetric induction including asymmetric desymmetrization of σ-symmetric 1,7-diols, 1,7-diamines, and bis-phenols have also been developed. The concept for the remote asymmetric induction has successfully been applied to a highly efficient synthesis of optically pure topologically chiral rotaxanes by kinetic resolution of the racemates. Site-selective asymmetric C-C bond formation and site-selective asymmetric epoxidation of diene compounds have been developed. Site-selective C(sp2)-H amination of arenes and remote asymmetric C(sp2)-H amination has been also developed.
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