| Budget Amount *help |
¥194,740,000 (Direct Cost: ¥149,800,000、Indirect Cost: ¥44,940,000)
Fiscal Year 2018: ¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2017: ¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2016: ¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2015: ¥36,660,000 (Direct Cost: ¥28,200,000、Indirect Cost: ¥8,460,000)
Fiscal Year 2014: ¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
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| Outline of Final Research Achievements |
We studied the roles of the Akt substrate and actin-binding protein, Girdin and its family protein, Daple in the development of psyco-neurologic disorder and cancer. We found that Girdin is involved in the synapse formation of hippocampal neurons and their long-term potentiation. In addition, Girdin was shown to play an important role in cancer cell collective migration, and its phosphorylation in cancer-associated fibroblasts (CAF) is essential for CAF migration which leads to tumor progression.
We showed that Daple-deficient mice present hydrocephalus and their ependymal cilia lack coordinated orientation. Daple regulates microtubule dynamics at the anterior side of ependymal cells, which in turn orients the cilial basal bodies . These results demonstrate an important role for Daple in planar polarity in motile cilia. Moreover, we elucidated that Daple is involved in the activation of Wnt signaling, promoting invasion and metastasis of gastric cancer cells.
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