| Budget Amount *help |
¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000)
Fiscal Year 2018: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2017: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2016: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2015: ¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2014: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000)
|
|---|
| Outline of Final Research Achievements |
The study aims to clarify the molecular mechanisms how pathogenic immunological memory T cells, which are harmful to organism, are differentiated and maintained for a long time. We have (1) explored the epigenetic regulation mechanism responsible for transcriptional memory using “Pathogenic Memory Th2 cell”, which causes allergic airway inflammation; (2) identified fibrosis-inducing pathogenic Th2 cells; (3) analyzed functional conversion and maintenance mechanism of memory T cell by polycomb and trithorax group gene products; and (4) elucidated the environmental factors to develop the control methods for allergic inflammation. In this study, we used human samples and got a proof of concept that was obtained using mouse models of allergic airway inflammation. Thus, we provide a significant insight into Human Immunology and Pathophysiology of intractable inflammatory diseases in patients.
|
