Intrinsic and extrinsic Mechanism underlying generation and maintenance of memory B cells

• Project/Area Number: 26221306
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: Kurosaki Tomohiro 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) (50178125)
• Co-Investigator(Kenkyū-buntansha): 福山 英啓 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (70303956)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000); Fiscal Year 2018: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2017: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2016: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000); Fiscal Year 2015: ¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000); Fiscal Year 2014: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
• Keywords: メモリーB細胞 / 胚中心B細胞 / インフルエンザ感染 / 変異ウイルス / エピトープ認識 / 免疫学 / T細胞ヘルプ / プラズマ細胞 / BCRシグナル / CD40シグナル / 液性免疫記憶 / メモリーTfh / メモリーB亜細胞 / 高親和性獲得 / Foxo1 / BATF / 液性免疫 / Bach2 / 抗原 / Affinity / Bcl6

Outline of Final Research Achievements

Once the pathogen invades into our body, the immune system operates and remembers this pathogen for long time. Then, when the same pathogen is invaded again, our immune system is able to respond to it quickly, thereby eliminating the pathogen very efficiently. Here, we have been addressing the mechanism how memory B cells are generated and long-lived.
Upon infection, B cells undergo GC reactions, whereby IgM to IgG class-switching and generation of high-affinity IgG GC B cells take place. During GC reactions, GC B cells take fate decisions; differentiation to plasma cells or to memory B cells. We found that among GC B cells, IgG B cells harboring intermediate and broad affinities are selected into the memory B cell pool. In addition, generated IgG memory B cells require BAFF receptor and IgG receptor for their long-lasting survival.

Academic Significance and Societal Importance of the Research Achievements

インフルエンザウイルスに対する致死率は依然として高いままであり効果的な新規ワクチンの開発が待望されている。メモリーB/T細胞はワクチンの効果発現のための必須細胞であるにもかかわらず生体内で少数しか存在しない等の実験的困難さがあり研究の進展が非常に阻まれていた領域である。本研究はその困難な点を克服するために新規研究手法を樹立し、機能的メモリーB細胞の生成・長期生存メカニズムに関して大きな一歩を記したものでその重要性は国際免疫学会、Keystoneシンポジウムで成果発表を要請されたことよりも明らかである。又、インフルエンザ等致死率の高い感染症に対する新規ワクチン開発への大きな貢献をするものである。

Assessment Rating

Verification Result (Rating)

A

Research Products

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• [Journal Article] KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity (2018)
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• [Journal Article] Generation of memory B cells and their reactivation. (2018)
  • Author(s): Inoue T, Moran I, Shinnakasu R, Phan TG, Kurosaki T.
  • Journal Title: Immunological Reviews Volume: 283(1) Issue: 1 Pages: 138-149
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate (2018)
  • Author(s): Ise Wataru、Fujii Kentaro、Shiroguchi Katsuyuki、Ito Ayako、Kometani Kohei、Takeda Kiyoshi、Kawakami Eiryo、Yamashita Kazuo、Suzuki Kazuhiro、Okada Takaharu、Kurosaki Tomohiro
  • Journal Title: Immunity Volume: 48 Issue: 4 Pages: 702-715
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  • Peer Reviewed / Open Access
• [Journal Article] The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection (2018)
  • Author(s): Raju Saravanan、Kometani Kohei、Kurosaki Tomohiro、Shaw Andrey S.、Egawa Takeshi
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  • Peer Reviewed / Open Access / Int'l Joint Research
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  • Author(s): Mendoza Pilar、Martinez-Martin Nuria、Bovolenta Elena R.、Reyes-Garau Diana、Hernansanz-Agustin Pablo、Delgado Pilar、 Diaz-Munoz Manuel D.、Oeste Clara L.、Fernandez-Pisonero Isabel、Castellano Ester、Martinez-Ruiz Antonio、 Alonso-Lopez Diego、Santos Eugenio、Bustelo Xose R.、Kurosaki Tomohiro、Alarcon Balbino
  • Journal Title: Science Signaling Volume: 11 Issue: 532
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• [Journal Article] Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. (2018)
  • Author(s): Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.
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• [Journal Article] Trim33 mediates the proinflammatory function of Th17 cells (2018)
  • Author(s): Tanaka Shinya、Jiang Yu、Martinez Gustavo J.、Tanaka Kentaro、Yan Xiaowei、Kurosaki Tomohiro、Kaartinen Vesa、Feng Xin-Hua、Tian Qiang、Wang Xiaohu、Dong Chen
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• [Journal Article] The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS (2018)
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• [Journal Article] The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. (2017)
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• [Journal Article] A distinct subpopulation of CD25－ T-follicular regulatory cells localizes in the germinal centers (2017)
  • Author(s): James Badger Wing, Yohko Kitagawa, Michela Locci, Hannah Hume, Christopher Tay, Takayoshi Morita, Yujiro Kidani, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, and Shimon Sakaguchi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 114 Issue: 31 Pages: 6400-6400
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis. (2017)
  • Author(s): Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.
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• [Journal Article] Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. (2017)
  • Author(s): Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, Kurosaki T, Ono K, Ito H.
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• [Journal Article] BACH transcription factors in innate and adaptive immunity (2017)
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• [Journal Article] Regulation of memory B and plasma cell differentiation. (2017)
  • Author(s): Shinnakasu R, Kurosaki T.
  • Journal Title: Curr. Opin. Immunol. Volume: 45 Pages: 126-131
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. (2016)
  • Author(s): Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K.
  • Journal Title: Nature Communications Volume: in press Issue: 1 Pages: 11205-11205
  • DOI: 10.1038/ncomms11205
  • NAID: 120007135549
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling (2016)
  • Author(s): Taishi Onodera, Akira Hosono, Takato Odagiri, Masato Tashiro, Shuichi Kaminogawa, Yoshinobu Okuno, Tomohiro Kurosaki, Manabu Ato, Kazuo Kobayashi, and Yoshimasa Takahashi
  • Journal Title: Journal of Immunology Volume: 196(10) Issue: 10 Pages: 4172-84
  • DOI: 10.4049/jimmunol.1600046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulated selection of germinal center cells into the memory B cell compartment. (2016)
  • Author(s): Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki,T.
  • Journal Title: Nat. Immunol. Volume: 17 Issue: 7 Pages: 861-9
  • DOI: 10.1038/ni.3460
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• [Journal Article] Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. (2016)
  • Author(s): Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 12596-12596
  • DOI: 10.1038/ncomms12596
  • Peer Reviewed / Open Access
• [Journal Article] Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 (2016)
  • Author(s): Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S
  • Journal Title: Nat Commun Volume: 7 Issue: 1 Pages: 12756-12756
  • DOI: 10.1038/ncomms12756
  • NAID: 120006535062
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• [Journal Article] Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. (2016)
  • Author(s): Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H.
  • Journal Title: Genes. Dev. Volume: 30 Issue: 22 Pages: 2475-2485
  • DOI: 10.1101/gad.290593.116
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• [Journal Article] Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. (2016)
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  • Journal Title: Immunity. Volume: 45(6) Issue: 6 Pages: 1299-1310
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• [Journal Article] mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes. (2016)
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  • Journal Title: PLoS One. Volume: 11 Issue: 1 Pages: e0146955-e0146955
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• [Journal Article] Role of Calcium Signaling in B Cell Activation and Biology. (2016)
  • Author(s): Baba Y, Kurosaki T.
  • Journal Title: Curr Top Microbiol Immunol. Volume: 393 Pages: 143-74
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  • ISBN: 9783319261317, 9783319261331
• [Journal Article] Regulated selection of germinal center cells into the memory B cell compartment. (2016)
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  • Journal Title: Nat Immunol. Volume: in press
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• [Journal Article] Responsiveness of B cells is regulated by the hinge region of IgD. (2015)
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  • Journal Title: Nat. Immunol. Volume: 16 Issue: 5 Pages: 534-43
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• [Journal Article] Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. (2015)
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  • Journal Title: Sci Signal. Volume: 8 Issue: 366
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• [Journal Article] Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen. (2015)
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  • Journal Title: The Journal of Immunology Volume: 194 Issue: 6 Pages: 2673-2682
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• [Journal Article] CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. (2015)
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  • Journal Title: Journal of Experimental Medicine Volume: 212 Issue: 9 Pages: 1465-1479
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• [Journal Article] Distinct germinal center selection at local sites shapes memory B cell response to viral escape. (2015)
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• [Journal Article] Signals controlling the development and activity of regulatory B-lineage cells. (2015)
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• [Journal Article] Differentiation and maintenance of long-lived plasma cells. (2015)
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  • Acknowledgement Compliant
• [Journal Article] Memory B cells. (2015)
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  • Acknowledgement Compliant
• [Journal Article] 「IL-10産生B細胞による自己免疫疾患の抑制」 (2015)
  • Author(s): 馬場義裕、黒崎知博
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• [Journal Article] Generation of colonic IgA-secreting cells in the cecal patch (2014)
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  • Journal Title: Nature Comm Volume: 5 Issue: 1 Pages: 3704-3704
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• [Journal Article] Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells. (2014)
  • Author(s): Ise W, Inoue T, McLachlan JB, Kometani K, Kubo M, Okada T, Kurosaki T
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• [Journal Article] Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. (2014)
  • Author(s): Mastumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nut, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T., and Baba, Y.
  • Journal Title: Immunity Volume: 41 Issue: 6 Pages: 1040-1051
  • DOI: 10.1016/j.immuni.2014.10.016
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• [Journal Article] CCAAT/Enhancer-Binding Protein α Negatively Regulates IFN-γ Expression in T Cells. (2014)
  • Author(s): Tanaka, S., et al.
  • Journal Title: J Immunol. Volume: 193 Issue: 12 Pages: 6152-60
  • DOI: 10.4049/jimmunol.1303422
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4. (2014)
  • Author(s): Wing, JB. Ise, W. Kurosaki, T. Sakaguchi, S.
  • Journal Title: Immunity Volume: 41 Issue: 6 Pages: 1013-25
  • DOI: 10.1016/j.immuni.2014.12.006
  • Peer Reviewed / Open Access
• [Presentation] Selection Mechanisms of Germinal Center Cells into the Memory B Cell Compartment (2019)
  • Author(s): Kurosaki, T
  • Organizer: B Cell-T Cell Interactions, Keystone Symposia Conference
  • Int'l Joint Research / Invited
• [Presentation] Bリンパ球運命決定機構 (2018)
  • Author(s): 黒崎知博
  • Organizer: 国立感染症研究所 セミナー
  • Invited
• [Presentation] Bリンパ球運命決定機構 (2018)
  • Author(s): 黒崎知博
  • Organizer: 順天堂大学 セミナー
  • Invited
• [Presentation] Fate decision of germinal center B cells (2018)
  • Author(s): Kurosaki, T
  • Organizer: B Cells: Mechanisms in Immunity and Autoimmunity Keystone Symposia Conference
  • Int'l Joint Research / Invited
• [Presentation] 液性免疫記憶生成機構 (2018)
  • Author(s): 黒崎知博
  • Organizer: 免疫サマースクール
  • Int'l Joint Research / Invited
• [Presentation] Fate decision of germinal center B cells (2018)
  • Author(s): Kurosaki, T
  • Organizer: Japanese-German Immunology Workshop
  • Int'l Joint Research / Invited
• [Presentation] Two humoral memory compartments: How are they generated? (2018)
  • Author(s): Kurosaki, T
  • Organizer: Universidad Autonoma de Madrid | UAM Seminar
  • Invited
• [Presentation] Regulation of B cell tolerance by epigenetic factors (2018)
  • Author(s): Kurosaki, T
  • Organizer: Cluster Science Days 2018 and the 10th international symposium of IFReC
  • Int'l Joint Research / Invited
• [Presentation] Fate decision of germinal center B cells (2018)
  • Author(s): Kurosaki, T
  • Organizer: International Symposium on B cells
  • Int'l Joint Research / Invited
• [Presentation] Selection of germinal-center B cells into memory B cell or plasma cell Compartment (2017)
  • Author(s): Kurosaki, T.
  • Organizer: The 6th NIF Winter School on Advanced Immunology
  • Place of Presentation: Singapore
  • Year and Date: 2017-01-22
  • Invited
• [Presentation] 液性免疫オペレーション機構 (2017)
  • Author(s): 黒崎知博
  • Organizer: 免疫サマースクール
  • Invited
• [Presentation] Selection mechanism of germinal center cells into plasma fate (2017)
  • Author(s): Kurosaki, T.
  • Organizer: The 19th Germinal Centre Conference
  • Int'l Joint Research
• [Presentation] Selection of Germinal Center B Cells into the Memory B Cell or Plasma Cell Compartment (2017)
  • Author(s): Kurosaki, T.
  • Organizer: KAI Internation Meeting 2017
  • Int'l Joint Research / Invited
• [Presentation] 液性免疫記憶オペレーション機構 (2017)
  • Author(s): 黒崎知博
  • Organizer: 2017年度生命科学系学会合同年次大会（ConBio2017）
  • Invited
• [Presentation] Selection mechanisms of germinal center B cells into the memory B cell compartment (2016)
  • Author(s): Shinnakasu, R.
  • Organizer: 45th Annual Meeting of the Japanese Society for Immunology.
  • Place of Presentation: 沖縄コンベンションセンター、沖縄
  • Year and Date: 2016-12-05
  • Invited
• [Presentation] Fate decisions of germinal center B cells into the memory B cell or plasma cell compartment (2016)
  • Author(s): Kurosaki, T.
  • Organizer: 4th Antibody Symposium
  • Place of Presentation: Singapore
  • Year and Date: 2016-11-14
  • Invited
• [Presentation] Fate decisions of germinal center B cells into the memory B cell or plasma cell compartment (2016)
  • Author(s): Kurosaki, T.
  • Organizer: The International Symposium for Advanced Immunology Commemorating the 10th anniversary of IFReC and the 77th anniversary of Prof. Tadamitsu Kishimoto's birth
  • Place of Presentation: Osaka International Convention Center, Osaka, Japan
  • Year and Date: 2016-11-01
  • Int'l Joint Research / Invited
• [Presentation] Overview of germinal center immunity (2016)
  • Author(s): Kurosaki, T.
  • Organizer: The 13th International Workshop on Autoantibodies and Autoimmunity (IWAA2016)
  • Place of Presentation: The Westin Miyako Kyoto, Kyoto, Japan
  • Year and Date: 2016-10-11
  • Int'l Joint Research / Invited
• [Presentation] Memory B cell generation mechanisms (2016)
  • Author(s): Kurosaki, T.
  • Organizer: Annual program of monthly lectures
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] Transcriptional regulation in memory B cell development (2016)
  • Author(s): Kurosaki, T.
  • Organizer: EMBO conference “Lymphocyte Antigen Receptor Signaling”
  • Place of Presentation: Siena, Italy
  • Year and Date: 2016-09-03
  • Int'l Joint Research / Invited
• [Presentation] Instructive selection of germinal center B cells into the memory compartment (2016)
  • Author(s): Kurosaki, T.
  • Organizer: International congress of Immunology 2016
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2016-08-21
  • Int'l Joint Research / Invited
• [Presentation] Instructive selection of germinal center B cells into the memory compartment (2016)
  • Author(s): Kurosaki, T.
  • Organizer: Antibody and Fc Receptor Biology: Bench to Bedside A Special Symposium to Honor Jeffrey V. Ravetch on his 65th Birthday
  • Place of Presentation: New York, USA
  • Year and Date: 2016-05-09
  • Int'l Joint Research / Invited
• [Presentation] B細胞を介する自己免疫抑制 (2016)
  • Author(s): 黒崎知博
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-04-21
  • Invited
• [Presentation] Selection mechanisms of germinal center cells into memory compartment (2016)
  • Author(s): 黒崎知博
  • Organizer: The Fifth Bizan Immunology Symposium at University of Tokushima (BISUT5) “Immune System Development, Deviation, and Regulation”
  • Place of Presentation: University of Tokushima, Tokushima
  • Year and Date: 2016-03-03
  • Invited
• [Presentation] 「メモリーB細胞生成メカニズム」 (2016)
  • Author(s): 黒崎知博
  • Organizer: ウイルス研究所セミナー
  • Place of Presentation: 京都大学、京都
  • Year and Date: 2016-02-03
  • Invited
• [Presentation] Instructive selection of germinal center B cells into the memory compartment. (2015)
  • Author(s): Kurosaki, T
  • Organizer: The 3rd Symposium of International Immunological Memory and Vaccine Forum (IIMVF)“What´s Immunological Memory?”
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2015-10-30
  • Int'l Joint Research / Invited
• [Presentation] Regulatory functions of B lineage cells (2015)
  • Author(s): 黒崎知博
  • Organizer: 第２回ＦｃＲ研究フォーラム２０１５
  • Place of Presentation: 仙台
  • Year and Date: 2015-10-23
  • Invited
• [Presentation] Selection of germinal centre B cells into memory compartment. (2015)
  • Author(s): Kurosaki, T.
  • Organizer: 1st International Symposium on B cells :Immunity and Autoimmunity
  • Place of Presentation: Erlangen, Germany
  • Year and Date: 2015-10-01
  • Int'l Joint Research / Invited
• [Presentation] Regulatory functions of B lineage cells (2015)
  • Author(s): Kurosaki, T.
  • Organizer: Institute of Molecular Medicine University Hospital Dusseldorf
  • Place of Presentation: Dusseldorf Germany
  • Year and Date: 2015-09-28
  • Invited
• [Presentation] 「B細胞を介する免疫抑制機能」 (2015)
  • Author(s): 黒崎知博
  • Organizer: セミナー
  • Place of Presentation: 秋田大学
  • Year and Date: 2015-09-25
  • Invited
• [Presentation] B細胞「生誕50年を迎えたBリンパ球研究の新展開」 (2015)
  • Author(s): 黒崎知博
  • Organizer: 免疫サマースクール
  • Place of Presentation: 淡路島
  • Year and Date: 2015-07-21
  • Invited
• [Presentation] Regulation of early B cell development by the CCR4-NOT mRNA deadenylase complex. (2015)
  • Author(s): Kurosaki, T.
  • Organizer: RIKEN IMS-JSI International Symposium on Immunology 2015 Infection and Immunity.
  • Place of Presentation: 横浜
  • Year and Date: 2015-06-18
  • Int'l Joint Research / Invited
• [Presentation] Calcium Signaling in B lymphocytes. (2015)
  • Author(s): Kurosaki, T.
  • Organizer: FASEB Signal Transduction in the Immune System.
  • Place of Presentation: Big Sky, USA
  • Year and Date: 2015-06-07
  • Int'l Joint Research / Invited
• [Presentation] Cellular and molecular basis for humoral memory responses. (2015)
  • Author(s): Kurosaki, T.
  • Organizer: The 4th NIF Winter School on Advanced Immunology.
  • Place of Presentation: Singapore
  • Year and Date: 2015-01-18 – 2015-01-23
  • Invited
• [Presentation] Involvement of transcription factors in generation of memory B cells. (2014)
  • Author(s): Kurosaki, T.
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
  • Invited
• [Presentation] Mechanisms underlying rapid memory IgG responses (2014)
  • Author(s): Kurosaki, T.
  • Organizer: International Seminar Series. Institute for Basic Science
  • Place of Presentation: Gyeongbuk, Korea
  • Year and Date: 2014-12-03
  • Invited
• [Presentation] Regulatory functions of B lineage cells. (2014)
  • Author(s): Kurosaki, T.
  • Organizer: France-Japan Immunology Meeting.
  • Place of Presentation: Cassis, France
  • Year and Date: 2014-10-22 – 2014-10-23
  • Invited
• [Presentation] B細胞を介する免疫制御 (2014)
  • Author(s): 黒崎知博
  • Organizer: 第42回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] Calcium signaling in B lymphocytes (2014)
  • Author(s): Kurosaki, T.
  • Organizer: The 5th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels
  • Place of Presentation: Isparta Turkey
  • Year and Date: 2014-09-09 – 2014-09-12
  • Invited
• [Presentation] Mechanisms underlying rapid memory IgG responses (2014)
  • Author(s): Kurosaki, T.
  • Organizer: The 2nd Symposium of International Immunological Memory and Vaccine Forum.
  • Place of Presentation: La Jolla, USA
  • Year and Date: 2014-08-25 – 2014-08-26
  • Invited
• [Presentation] B細胞を介する免疫制御 (2014)
  • Author(s): 黒崎知博
  • Organizer: ＪＳＩ免疫サマースクール
  • Place of Presentation: 香川県小豆島
  • Year and Date: 2014-07-28 – 2014-07-31
  • Invited
• [Book] Molecular Biology of B cells, Second Edition (2014)
  • Author(s): Reth M, Nitschke, L, Hikida, M, Kurosaki, T.
  • Total Pages: 600
  • Publisher: Academic Press, London, UK
• [Remarks] http://lymph.ifrec.osaka-u.ac.jp/
• [Remarks] Laboratory of Lymphocyte Differentiation
  • URL: http://lymph.ifrec.osaka-u.ac.jp/index_j.html
• [Remarks] http://lymph.ifrec.osaka-u.ac.jp/index_j.html