| Co-Investigator(Kenkyū-buntansha) |
小林 純也 京都大学, 放射線生物研究センター, 准教授 (30301302)
田内 広 茨城大学, 理学部, 教授 (70216597)
柳原 晃弘 (加藤 晃弘) 東北医科薬科大学, 医学部, 助教 (70423051)
松浦 伸也 広島大学, 原爆放射線医科学研究所, 教授 (90274133)
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| Budget Amount *help |
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2015: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2014: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Outline of Final Research Achievements |
We had reported several functional domains at the C-terminla of NBS1, which was identified as a protein responsible for radiation sensitive disease, Nijmegen breakage syndrome, by us in 1998. The functional roles of these domains were analyzed by using the cells lacking the specified domain or knock-in mice, which revealed the association with the radiation resistance at low dose irradiation in radiation therapy and with the genome instability, such as mutagenesis and carcinogenesis. Moreover, we found two novel functional domains in the C-terminal region and middle region, respectively. Analysis using CRISPRA technique indicated their functional roles in non-homologous end-joining for radiation-induced DNA double strand breaks and also in another genome stability.
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