| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2016: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2014: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Outline of Final Research Achievements |
Vagus nerve stimulation (VNS) is a palliative treatment of refractory epilepsy. VNS stimulates left vagus nerves intermittently with chronically implanted cuff electrodes. While VNS is generally recognized as being effective for inhibition of epileptic seizure, the mechanism of action still remains unknown. In the present study, we carried out both animal experiments and clinical studies to elucidate how VNS affects the neural activity in the cerebral cortex, which might modify higher-order brain functions such as perception, cognition, learning and memory as well as epileptic pathology.
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