| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2016: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2015: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2014: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
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| Outline of Final Research Achievements |
This study was undertaken to elucidate how the hemodynamic forces stretch and shear stress affect the physical properties of a vascular endothelial cell (EC) plasma membrane and whether plasma membranes can sense and differentiate between stretch and shear stress. The results demonstrated that EC plasma membranes show different responses to stretch and shear stress by rapidly changing their lipid order and fluidity in opposite directions. Artificial lipid bilayer membranes showed mechanoresponses that were similar to those of ECs, indicating that this is a physical phenomenon rather than a biological reaction. Furthermore, these changes in physical properties of the EC plasma membrane contribute to the mechanotransduction that activates membrane receptors specific to each force. Plasma membranes appear to have an intrinsic mechanoresponsive property and that this property seems to enable them to act as a mechanosensor that is capable of differentiating between stretch and shear stress.
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