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Pulse glucometry: Pioneering research towards practical non-invasive optical measurement of blood glucose

Research Project

Project/Area Number 26242044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionShowa University

Principal Investigator

Yamakoshi Ken-ichi  昭和大学, 医学部, 客員教授 (40014310)

Co-Investigator(Kenkyū-buntansha) 加藤 祐次  北海道大学, 情報科学研究科, 助教 (50261582)
山越 健弘  福岡工業大学, 情報工学部, 准教授 (70444205)
李 知炯  福岡工業大学, 情報工学部, 助教 (10735583)
清水 孝一  北海道大学, 情報科学研究科, 教授 (30125322)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2016: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2015: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2014: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords糖尿病 / 非侵襲光学的血糖計測 / パルス・グルコメトリ / グルコース吸収波長帯域 / 積分球式光電容積信号検出法 / 側方入射型光電容積信号検出法 / 光散乱現象 / 偏光変調型光電容積信号検出法 / グルコース吸光波長帯域 / 側方散乱光電容積脈波検出 / 組織内順直進光検出 / 生体光情報計測 / 側方散乱光電容積信号検出法 / 多波長レーザー光電容積信号計測システム / 生体光計測 / 近赤外生体センシング / レーザー計測システム / 多変量校正法 / 生体情報計測
Outline of Final Research Achievements

According to a statement issued by International Diabetes Federation, diabetes population in 2015 runs up to 415 million people and Japan has diabetes powers ranked 9th in the world. In a diabetic patient blood glucose (BGL) measurement, most desirably non-invasive method without blood sampling, is needed to control BGL level. Unfortunately such practical non-invasive method has not yet been developed up to now.
We have previously developed a novel non-invasive BGL measurement using a finger called “pulse glucometry” and evaluated its validity on an experimental basis. To realize technical practicability of this method, it is essential to develop a new finger-photoplethysmography (PPG) in a wavelength region with BGL absorption having quite high accuracy and sensitivity as well as convenient use. The present study was carried out focusing especially on this PPG development, aiming a basic establishment towards the world’s first non-invasive BGL measurement device for practical use.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Side-scattered finger-photoplethysmography: Experimental investigations towards practical noninvasive measurement of blood glucose2017

    • Author(s)
      Yamakoshi Y, Matsumura K, Yamakoshi T, Lee J, Rolfe P, Kato Y, Shimizu K, Yamakoshi K
    • Journal Title

      Journal of Biomedical Optics

      Volume: 22 Issue: 6 Pages: 1-11

    • DOI

      10.1117/1.jbo.22.6.067001

    • NAID

      120006335570

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inter-method relieability of pulse volume related measures derived using finger-photoplethysmography across sensor positions and light intensities2017

    • Author(s)
      Kenta Matsumura, Koichi Shimizu, Peter Rolfe and Takehiro Yamakoshi
    • Journal Title

      Journal of Psychophysiology

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smartphone Photoplethysmography:Toward Effective Utilization in Daily Life Measurement2016

    • Author(s)
      松村健太, 李知炯, 山越健弘
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 54 Issue: 3 Pages: 120-128

    • DOI

      10.11239/jsmbe.54.120

    • NAID

      130005285594

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrating sphere finger-photoplethysmography: preliminary investigation towards practical non-invasive measurement of blood constituents2015

    • Author(s)
      T. Yamakoshi, J. Lee, K. Matsumura, Y. Yamakoshi, P. Rolfe, D. Kiyohara,K. Yamakoshi
    • Journal Title

      PLOS One

      Volume: 10 Issue: 12 Pages: e0143506-e0143506

    • DOI

      10.1371/journal.pone.0143506

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A novel design of lateral incident radiation-type finger-photoplethysmography in the wavelength regions with blood glucose absorption2018

    • Author(s)
      Yamakoshi Y., Matsumura K., Yamakoshi T., Lee J., Motoi K., Shibata M., Rolfe P. and Yamakoshi K.
    • Organizer
      The 2018 World Congress on Medical Physics & Biomedical Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel multichannel laser photoplethysmogram for the detection of side-scattered light in a wavelength with blood glucose absorption2016

    • Author(s)
      Yasuhiro Yamakoshi, Kenta Matsumura, Takehiro Yamakoshi, Jihyoung Lee, Peter Rolfe, Kosuke Motoi, Masahiro Shibata, Yuji Kato, Koichi Shimizu and Ken-ichi Yamakoshi
    • Organizer
      38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Orland, USA
    • Year and Date
      2016-08-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] An integration sphere-type finger-photopletysmography with higher accuracy and sensitivity towords practical non-invasive measurement of blood constituents2015

    • Author(s)
      Yasuhiro Yamakoshi, Kenta. Matsumura, Takehiro Yamakoshi, Jihyoung Lee, Kosuke Motoi, Peter Rolfe and Ken-ichi Yamakoshi
    • Organizer
      The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano Conference Center
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非侵襲血中成分計測を目指した積分球型高感度光電容積脈波検出法の検討2015

    • Author(s)
      山越康弘、松村健太、山越健弘、田中直登、Jihyoung Lee、Peter Rolfe、清水孝一、山越憲一
    • Organizer
      第54回日本生体医工学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-05-07 – 2015-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非侵襲血中成分計測を目指した積分球型高感度光電容積脈波検出法の検討2015

    • Author(s)
      山越康弘, 松村健太, 山越健弘, 田中直登, 李知炯, ピーター・ロルフ, 清水孝一, 山越憲一
    • Organizer
      第54回日本生体医工学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of aging on vascular wall elasticity in human digital artery analyzed by photoplethysmographic pulsations2014

    • Author(s)
      Masahiro Shibata, Pichitra Uangpairoj and Ken-ichi Yamakoshi
    • Organizer
      6th European Conference of the International Federation for Medical and Biological Engineering
    • Place of Presentation
      Dubrovnik, Croatia
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非侵襲血中成分計測のための球状拡散反射面を用いた高感度光電容積脈波検出法の提案2014

    • Author(s)
      清原大樹,永井孝,Jihyoung Lee,松村健太,Peter Rolfe,山越憲一,田中直登,山越康弘,田中志信,野川雅道,山越健弘
    • Organizer
      第53回日本生体医工学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Book] ドライバ状態の検知・測定技術と運転支援・自動運転への応用2016

    • Author(s)
      山越健弘
    • Total Pages
      485
    • Publisher
      技術情報協会
    • Related Report
      2016 Annual Research Report
  • [Remarks] 福岡工業大学 大学院工学研究科 情報システム工学専攻 山越研究室ホームページ

    • URL

      http://www.fit.ac.jp/~yamakoshi

    • Related Report
      2016 Annual Research Report
  • [Remarks] 福岡工業大学 大学院工学研究科 情報システム工学専攻 山越研究室ホームページ

    • URL

      http://www.fit.ac.jp/~yamakoshi

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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