合目的機能の統合によるオールインワンナノメディシンの開発と非侵襲がん治療への展開

• Project/Area Number: 26242049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka Prefecture University
• Principal Investigator: 河野 健司 大阪府立大学, 工学研究科, 教授 (90215187)
• Co-Investigator(Kenkyū-buntansha): 青木 伊知男 国立研究開発法人放射線医学総合研究所, 分子イメージング診断治療研究部, チームリーダー (10319519) ; 宇高 恵子 高知大学, 教育研究部医療学系基礎医学部門, 教授 (40263066) ; 冨田 章裕 藤田保健衛生大学, 医学系研究科, 准教授 (80378215) ; 弓場 英司 大阪府立大学, 工学研究科, 助教 (80582296)
• Project Period (FY): 2014 – 2016
• Project Status: Discontinued (Fiscal Year 2016)
• Budget Amount: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000); Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000); Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2014: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
• Keywords: 薬物送達システム / ナノ医療 / がん治療

Outline of Annual Research Achievements

平成28年度は、オールインワンナノ治療デバイスとして、温度応答機能、MRIや近赤外外蛍光イメージングによる可視化機能に加えて標的病巣がん細胞へのターゲティング機能を持たせるために、CD20陽性Bリンパ腫に特異性をもつリツキシマブを結合した多重機能リポソームや、金ナノロッドーデンドリマー複合体を作製し、そのキャラクタリゼーションと細胞実験を行った。リポソームや金ナノロッドハイブリッドにリツキシマブを結合することで、CD20陽性細胞へのキャリアの取り込みが大幅に上昇し、加温下や近赤外レーザー照射下において封入した抗がん剤が放出されることで高い細胞成長阻害効果が見られた。また、金ナノロッドと非対称デンドリマーからなるオールインワンナノベクターの開発について、粒径40nm程度の金ナノロッドと温度応答性高分子の側鎖構造を修飾した非対称カチオニックデンドリマー(デンドロン脂質)を複合化させたナノハイブリッドを作製した。このナノハイブリッドは、プラスミドDNAと効率よく複合体を形成した。また近赤外レーザーを照射すると金ナノロッドが発熱し、デンドロン末端の温度応答性側鎖が疎水化し、キャリア表面の疎水性が増大することで、細胞により効率良く取り込まれ、高い遺伝子発現を導いた。このことから、光・熱応答型遺伝子ベクターとして機能することがわかった。さらに、オールインワンナノワクチンとして、pH応答性基を導入した多糖誘導体被覆リポソームに、カチオン性脂質を組み込むと、従来の脂質アジュバントであるMPLAよりも極めて効果的に樹状細胞を活性化し、CTLの誘導に重要なサイトカインIL-12が大量に産生された。また、MPLAを含有したpH応答性ポリマー・pH応答性デンドロン脂質修飾リボソームをがん抗原ペプチドのデリバリーシステムとして用いるとそれぞれCTL・ヘルパーT細胞の誘導効率が増大することも明らかにした。

Research Progress Status

28年度が最終年度であるため、記入しない

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない

Research Products

• [Journal Article] Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions (2016)
  • Author(s): S. A. Chechetka, E. Yuba, K. Kono, M. Yudasaka, A. Bianco, E. Miyako
  • Journal Title: Angew. Chem. Int. Ed Volume: 55 Issue: 22 Pages: 6476-6481
  • DOI: 10.1002/anie.201602453
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Intracellular Protein-Protein Interaction Inhibitors by Epitope and Arginine Grafting (2016)
  • Author(s): Daisuke Fujiwara, Hidekazu Kitada, Masahiro Oguri, Toshio Nishihara, Masataka Michigami, Kazunori Shiraishi, Eiji Yuba, Ikuhiko Nakase, Haeri Im, Sunhee Cho, Jong Young Joung, Seiji Kodama, Kenji Kono, Sihyun Ham*, and Ikuo Fujii*
  • Journal Title: Angewandte Chemie International Edition Volume: 55 Issue: 36 Pages: 10612-10615
  • DOI: 10.1002/anie.201603230
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 免疫治療のためのDDS最前線 (2016)
  • Author(s): 弓場英司、原田敦史、河野健司
  • Journal Title: 高分子 Volume: 65 Pages: 435-440
  • Peer Reviewed
• [Journal Article] リポソームエンジニアリング : 高機能化・高性能化への挑戦 (2016)
  • Author(s): 河野健司
  • Journal Title: Drug Delivery System Volume: 31 Pages: 331-342
• [Journal Article] Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes. (2016)
  • Author(s): Yoshizaki Y, Yuba E, Komatsu T, Udaka K, Harada A, Kono K
  • Journal Title: Molecules Volume: 21 Issue: 10 Pages: 1284-1284
  • DOI: 10.3390/molecules21101284
  • Peer Reviewed / Open Access
• [Journal Article] Live-cell single-molecule imaging of the cytokine reoeptor MPL for analysis of dynamic dimerization. (2016)
  • Author(s): Sakamoto A, Tsukamoto T, Furutani Y, Sudo Y, Shimada K, Tomita A, Kiyoi H, Kato T, Funatsu T.
  • Journal Title: J Mol Cell Biol. Volume: 8 Pages: 553-555
  • Description: in process
  • Peer Reviewed
• [Journal Article] Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes. (2016)
  • Author(s): Suzuki Y, Tomita A, Nakamura F, Iriyama C, Shirahata-Adachi M, Shimada K, Akashi A, Ishikawa Y, Kaneda N, Kiyoi H.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 9 Pages: 1329-37
  • DOI: 10.1111/cas.12994
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. (2016)
  • Author(s): 2.Takagi Y, Shimada K*, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 9 Pages: 1270-1280
  • DOI: 10.1111/cas.13001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Japanese phase Ⅱ study of rituximab maintenance for untreated indolent B-cell non-Hodgk in lymphoma with high tumor burden. (2016)
  • Author(s): Igarashi T, Ogura M, Itoh K, Taniwaki M, Ando K, Kuroda Y, Yamamoto K, Uike N, Tomita A, Nagai H, Kurosawa M, Mori S, Nawano S, Terauchi T, Ohashi Y, Tobinai K.
  • Journal Title: Int J Hematol. Volume: 104 Pages: 700-708
  • Description: in process
  • Peer Reviewed
• [Journal Article] Genetic and Epigenetic Modulation of CD20 Expression in B-Cell Malignancies Molecular Mechanisms and Significance to Rituximab Resistance. (2016)
  • Author(s): Tomita A
  • Journal Title: J Clin Exp Hematop. Volume: 56 Pages: 89-99
  • NAID: 130005433863
  • Description: in process
  • Peer Reviewed / Open Access
• [Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs (2016)
  • Author(s): M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Sejju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura
  • Journal Title: OncoImmunology Volume: 5 Issue: 6 Pages: e1123368-e1123368
  • DOI: 10.1080/2162402x.2015.1123368
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of glypican-3-derived long peptides activating both CD8 and CD4 T cells; prolonged overall survival in cancer patients with Th cell response (2016)
  • Author(s): Sayem, M. A. Tomita, Y. Yuno, A. Hirayama, M. Irie, A. Tsukamoto, H. Senju, S. Yuba, E. Yoshikawa, T. Kono, K. Nakatsura, T. Nishimura, Y.
  • Journal Title: Oncoimmunology Volume: 5 Issue: 1 Pages: e1062209-e1062209
  • DOI: 10.1080/2162402x.2015.1062209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy (2015)
  • Author(s): I. Aoki, M. Yoneyama, J. Hirose, Y. Minemoto, T. Koyama, D. Kokuryo, R. Bakalova, S. Murayama, T. Saga, S. Aoshima, Y. Ishizaka, K. Kono,
  • Journal Title: Translational Research Volume: 166 Issue: 6 Pages: 660-673
  • DOI: 10.1016/j.trsl.2015.07.009
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] In vivo remote control of reactions in Caenorhabditis elegans by using supramolecular nanohybrids of carbon nanotubes and liposomes (2015)
  • Author(s): E. Miyako, S. A. Chechetka, M. Doi, E. Yuba, K. Kono
  • Journal Title: Angew. Chem. Int. Ed Volume: 54 Issue: 34 Pages: 9903-9906
  • DOI: 10.1002/anie.201504987
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multifunctional liposomes having target specificity, temperature-triggered release, and near-infrared fluorescence imaging for tumor-specific chemotherapy (2015)
  • Author(s): K. Kono, M. Takashima, E. Yuba, A. Harada, Y. Hiramatsu, H. Kitagawa, T. Otani, K. Maruyama, S. Aoshima
  • Journal Title: J. Control. Release Volume: 216 Pages: 69-77
  • DOI: 10.1016/j.jconrel.2015.08.005
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effective condensation of multivalent anions into polyion complex micelles prepared from TiO2 nanoparticles and polyallylamine bearing poly(ethylene glycol) grafts (2015)
  • Author(s): Satoshi Yamamoto, Eiji Yuba, Atsushi Harada and Kenji Kono
  • Journal Title: Langmuir Volume: 31 Issue: 31 Pages: 8583-8588
  • DOI: 10.1021/acs.langmuir.5b01883
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PAMAM dendron lipid assemblies that undergo structural transition in response to weakly acidic pH and their cytoplasmic delivery capability (2015)
  • Author(s): T. Doura, M. Yamada, R. Teranishi, Y. Yamamoto, T. Sugimoto, E. Yuba, A. Harada, K. Kono
  • Journal Title: Langmuir Volume: 印刷中 Issue: 18 Pages: 5105-5114
  • DOI: 10.1021/acs.langmuir.5b00183
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] pH-Sensitive polymer-liposome-based antigen delivery systems potentiated with interferon-γ gene lipoplex for efficient cancer immunotherapy (2015)
  • Author(s): E. Yuba, Y. Kanda, Y. Yoshizaki, R. Teranishi, A. Harada, K. Sugiura, T. Izawa, J. Yamate, N. Sakaguchi, K. Koiwai, K. Kono,
  • Journal Title: Biomaterials Volume: 67 Pages: 214-224
  • DOI: 10.1016/j.biomaterials.2015.07.031
  • NAID: 120007159642
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Gene expression of ternary complexes through the compaction of nanofiber-polyplexes by mixing with Lipofectamine (2015)
  • Author(s): R. Aono, K. Nomura, E. Yuba, A. Harada, K. Kono
  • Journal Title: Biomaterials Science Volume: in press Issue: 5 Pages: 1-7
  • DOI: 10.1039/c5bm00081e
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Facile construction of well-defined fullerene-dendrimer supramolecular nanocomposites for bioapplications (2015)
  • Author(s): Xiaojie Li, Yasuo Watanabe, Eiji Yuba, Atsushi Harada, Takeharu Haino, Kenji Kono
  • Journal Title: Chemical Communications Volume: 51 Issue: 14 Pages: 2851-2854
  • DOI: 10.1039/c4cc09082a
  • Peer Reviewed
• [Journal Article] Evaluation of Thermo-triggered Drug Release in Intramuscular-transplanted Tumors using Thermosensitive Polymer-modified Liposomes and MRI (2015)
  • Author(s): Daisuke Kokuryo, Seiji Nakashima, Fuminori Ozaki, Kai-Hsiang Chuang, Sadahito Aoshima, Yukihito Ishizaka, Tsuneo Saga, Kenji Kono, and Ichio Aoki
  • Journal Title: Nanomedicine Volume: 11 Issue: 1 Pages: 229-238
  • DOI: 10.1016/j.nano.2014.09.001
  • Peer Reviewed
• [Journal Article] Synthesis of oligoethylene glycol-modified hyperbranched polyglycidols for dual sensitization of liposomes to pH and temperature (2014)
  • Author(s): K. Kono, T. Kaiden, E. Yuba, Y. Sakanishi, A. Harada
  • Journal Title: J. Taiwan Institute of Chemical Engineers Volume: 45 Issue: 6 Pages: 3054-3061
  • DOI: 10.1016/j.jtice.2014.06.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effective enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a new type synthetic vector. (2014)
  • Author(s): Wijesekera, D.P.H., Sugiura, K., Yuba, E., Ueda, K., Wijewardana, V., Kanegi, R., Nishimura, T., Ushigusa, T., Hatoya, S., Kono, K., Inaba, T.
  • Journal Title: Vet. Immunol. Immunopathol. Volume: 162 Issue: 1-2 Pages: 59-64
  • DOI: 10.1016/j.vetimm.2014.08.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Potentiation of pH-sensitive polymer-modified liposomes with cationic lipid inclusion as antigen delivery carriers for cancer immunotherapy (2014)
  • Author(s): Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono
  • Journal Title: Biomaterials Volume: 35 Issue: 28 Pages: 8186-8196
  • DOI: 10.1016/j.biomaterials.2014.05.077
  • NAID: 120007159643
  • Peer Reviewed
• [Journal Article] Application of pH-sensitive fusogenic polymer-modified liposomes for development of mucosal vaccines (2014)
  • Author(s): S. Watarai, T. Iwase, T. Tajima, E. Yuba, K. Kono, Y. Sekiya
  • Journal Title: Veterinary Immunology and Immunopathology Volume: 158 Issue: 1-2 Pages: 62-72
  • DOI: 10.1016/j.vetimm.2013.05.005
  • Peer Reviewed
• [Journal Article] Dually functionalized dendrimers by temperature-sensitive surface modification and gold nanoparticle loading for biomedical application (2014)
  • Author(s): K. Kono, K. Takeda, X. Li, E. Yuba, A. Harada, T. Ozaki, S. Mori
  • Journal Title: RSC Adv. Volume: 4 Issue: 53 Pages: 27811-27819
  • DOI: 10.1039/c4ra03947e
  • Peer Reviewed
• [Journal Article] Preparation of PEG-modified PAMAM dendrimers having gold nanorod core and their application to photothermal therapy (2014)
  • Author(s): X. Li, K. Takeda, E. Yuba, A. Harada, K. Kono
  • Journal Title: J. Mater. Chem. B Volume: 2 Issue: 26 Pages: 4167-4176
  • DOI: 10.1039/c4tb00132j
  • Peer Reviewed
• [Journal Article] PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy (2014)
  • Author(s): X. Li, M. Takashima, E. Yuba, A. Harada, K. Kono
  • Journal Title: Biomaterials Volume: 35 Issue: 24 Pages: 6576-6584
  • DOI: 10.1016/j.biomaterials.2014.04.043
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nanofiber polyplex formation based on the morphology elongation by the intra-polyplex PEG crowding effect (2014)
  • Author(s): Ryuta Aono, Eiji. Yuba, Atsushi Harada, Kenji Kono
  • Journal Title: ACS Macro Letters Volume: 3 Issue: 4 Pages: 333-336
  • DOI: 10.1021/mz500072k
  • Peer Reviewed
• [Presentation] Emetine Elicits Apoptosis of Intractable B-Cell Lymphoma Cells with MYC Rearrangement through Inhibition of Glycolytic Metabolism (2016)
  • Author(s): Tomohiro Aoki, Kazuyuki Shimada, Akihiko Sakamoto, Keiki Sugimoto, Takanobu Morishita, Yuki Kojima, Satoko Shimada, Seiichi Kato, Chisako Iriyama, Shunsuke Kuno, Yasuhiko Harada, Shigeo Nakamura, Akihiro Tomita, Fumibiko Hayakawa and Hitoshi Kiyoi
  • Organizer: American Society of Hematology, 58th Annual Meeting & Exposition
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA,
  • Year and Date: 2016-12-04
• [Presentation] Development of effective immune-inducing system using pH-sensitive polysaocharide-modified liposomes and TGF-β signal inhibitor-embedded liposomes (2016)
  • Author(s): E. Yuba, S. Uesugi, A. Harada, K. Kono
  • Organizer: 3rd International Conference on Biomaterials Science in Tokyo (ICBS2016)
  • Place of Presentation: 東京、伊藤ホール
  • Year and Date: 2016-11-28
• [Presentation] pH-Sensitive polymer-modified liposome-based immunity inducing system : the effect of inclusion of cationic lipid and CpG-DNA (2016)
  • Author(s): Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono
  • Organizer: 3rd International Conference on Biomaterials Science in Tokyo(ICBS2016)
  • Place of Presentation: 東京、伊藤ホール
  • Year and Date: 2016-11-28
• [Presentation] Polyamidoamine dendrimer-gold nanorod hybrids for non-invasive photothermal chemotherapy (2016)
  • Author(s): T. Hashimoto, E. Yuba, A. Harada, K. Kono
  • Organizer: 3rd International Conference on Biomaterials Science in Tokyo(ICBS2016)
  • Place of Presentation: 東京、伊藤ホール
  • Year and Date: 2016-11-28
• [Presentation] Hyaluronic acid derivative-modified liposomes for a target-specific intracellular drug delivery system (2016)
  • Author(s): M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono
  • Organizer: 3rd International Conference on Biomaterials Science in Tokyo(ICBS2016)
  • Place of Presentation: 東京、伊藤ホール
  • Year and Date: 2016-11-28
• [Presentation] カードラン誘導体修飾リポソームの免疫誘導活性に及ぼすカチオン性脂質導入の効果 (2016)
  • Author(s): 門柚奈、弓場英司、坂口奈央樹、小岩井一倫、原田敦史、河野健司
  • Organizer: 日本バイオマテリアル学会シンポジウム2016
  • Place of Presentation: 博多、福岡国際会議場
  • Year and Date: 2016-11-21
• [Presentation] サイトカイン遺伝子と抗原の同時送達によるpH応答性リポソームワクチンの高活性化 (2016)
  • Author(s): 弓場英司、神田雄平、原田敦史、河野健司
  • Organizer: 日本バイオマテリアル学会シンポジウム2016
  • Place of Presentation: 博多、福岡国際会議場
  • Year and Date: 2016-11-21
• [Presentation] PEG修飾デンドリマー・金ナノロットハイブリッドベクターの作製 (2016)
  • Author(s): 松村和洋、弓場英司、原田敦史、河野健司
  • Organizer: 日本バイオマテリアル学会シンポジウム2016
  • Place of Presentation: 博多、福岡国際会議場
  • Year and Date: 2016-11-21
• [Presentation] cRGD結合温度応答性高分子修飾リポソームのDDS機能 : 従来型リポソームとの比較 (2016)
  • Author(s): 林孝彰、弓場英司、原田敦史、青島貞人、河野健司
  • Organizer: 日本バイオマテリアル学会シンポジウム2016
  • Place of Presentation: 博多、福岡国際会議場
  • Year and Date: 2016-11-21
• [Presentation] がん免疫療法の開発戦略 -抗原提示の視点から- (2016)
  • Author(s): 宇高 恵子
  • Organizer: 日本臨床麻酔学会第36回大会
  • Place of Presentation: 高知県高知市、高知県立県民文化ホール
  • Year and Date: 2016-11-04
  • Invited
• [Presentation] Preparation of Multifunctional Dendrimer-Gold Nanorod Hybrid and Their Application to Photothermal Chemotherapy (2016)
  • Author(s): T. Hashimoto, E. Yuba, A. Harada, K. Kono
  • Organizer: Biomaterials International2016
  • Place of Presentation: 墾丁、Howard Beach Resort Kenting
  • Year and Date: 2016-10-30
• [Presentation] Preparation of Polysaocharide Derivatives Having pH-Sensitivity and Immune Activation Function (2016)
  • Author(s): E. Yuba, A. Yamaguchi, A. Harada, K. Kono
  • Organizer: Biomaterials International2016
  • Place of Presentation: 墾丁、Howard Beach Resort Kenting
  • Year and Date: 2016-10-30
• [Presentation] Discovering the novel drug targeting tumor-microenvironment for intractable lymphoma (2016)
  • Author(s): 青木智広、島田和之、坂本明彦、森下喬允、原田靖彦、入山智沙子、早川文彦、冨田章裕、清井仁
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-10-15
• [Presentation] Possibility of retreatment with bendamustine-rituximab in relapsed/refractory mantle cell lymphoma (2016)
  • Author(s): 伊藤佳織、岡本昌隆、稲熊容子、岡本晃直、徳田倍将、安藤舞子、安藤洋介、柘植雅大、加藤梓沙、島戸茜、林高弘、冨田章裕、赤塚美樹、山田成樹、恵美宣彦
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-10-14
• [Presentation] Liposome engineering for efficient cancer immunotherapy(Invited lecture) (2016)
  • Author(s): E. Yuba, K. Kono
  • Organizer: 12^<th> IUPAC International Conference NMS-XII
  • Place of Presentation: 長沙、湖南農業大学
  • Year and Date: 2016-10-14
• [Presentation] Relationship between tissue EBV-DNA copy number and pathological classification/subtypes in LPDs (2016)
  • Author(s): 岡本晃直、岡本昌隆、冨田章裕、稲熊容子、徳田倍将、柳田正光、蟹江匡治、山本幸也、赤塚美樹、吉川哲史、恵美宣彦
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-10-13
• [Presentation] Transcriptional activation of PDGFRA and GSX2 by ETV6 translocation in a case of AML witht(4;12) (2016)
  • Author(s): 安部明弘、水田秀一、山本幸也、岡本晃直、伊庭佐知子、徳田倍将、稲熊容子、柳田正光、森島聡子、蟹江匡治、冨田章裕、赤塚美樹、岡本昌隆、亀山俊樹、前田明、恵美宣彦
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-10-13
• [Presentation] Simultaneous delivery system of antigenic protein and cytokine gene using hybrid complexes of pH-sensitive polymer-modified liposome and lipoplex (2016)
  • Author(s): E. Yuba, Y. Kanda, A. Harada, K. Kono
  • Organizer: 4^<th> Symposium on Innovative Polymers for Controlled Delivery
  • Place of Presentation: 蘇州、Worldhotel Grand DushuLake
  • Year and Date: 2016-09-23
• [Presentation] カルボキシ基導入多糖修飾リポソームのpH応答性・抗原デリバリー機能に及ぼす側鎖構造の影響 (2016)
  • Author(s): 弓場 英司、上杉慎也、原田 敦史、河野 健司
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 横浜、神奈川大学横浜キャンパス
  • Year and Date: 2016-09-14
• [Presentation] 異なる細胞内分布を示す音増感剤デリバリーと超音波力学療法効果 (2016)
  • Author(s): 原田 敦史、寺西諒真、松田賢之、弓場 英司、河野 健司
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 横浜、神奈川大学横浜キャンパス
  • Year and Date: 2016-09-14
• [Presentation] 多分岐PEG被覆ポリプレックスのアスペクト比と遺伝子導入効果の相関 (2016)
  • Author(s): 原田 敦史、勝圓由希子、野村健太、弓場 英司、河野 健司
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 横浜、神奈川大学横浜キャンパス
  • Year and Date: 2016-09-14
• [Presentation] 弱酸性pHで構造転移するデンドロン脂質集合体の調製とサイトゾルデリバリーシステムへの展開 (2016)
  • Author(s): 弓場 英司、堂浦智裕、山田めぐみ、原田 敦史、河野 健司
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 横浜、神奈川大学横浜キャンパス
  • Year and Date: 2016-09-14
• [Presentation] siRNAと多分岐PEG導入ポリ-L-リシンからのumbrellaplexの調製と機能評価 (2016)
  • Author(s): 大村啓輔、弓場 英司、原田 敦史、河野 健司
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 横浜、神奈川大学横浜キャンパス
  • Year and Date: 2016-09-14
• [Presentation] T_1O_2ナノ粒子内包PICミセルへの超音波照射による樹状細胞サイトカイン産生能評価 (2016)
  • Author(s): 古川和樹、山本聡、弓場 英司、原田 敦史、河野 健司
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 横浜、神奈川大学横浜キャンパス
  • Year and Date: 2016-09-14
• [Presentation] 血管内皮細胞のHLAクラスⅡ発現は、T細胞浸潤及び膵腫瘍に対する傷害活性と関連する (2016)
  • Author(s): 宇高恵子、木岐 淳、西森 功、西原利治、小松利広、西岡千恵、鈴木勝英
  • Organizer: 第8回血液疾患免疫療法学会
  • Place of Presentation: 北海道札幌市、北海道大学
  • Year and Date: 2016-09-03
• [Presentation] 機能性高分子の表面修飾による細胞特異的リポソームDDSの設計 (2016)
  • Author(s): 弓場 英司
  • Organizer: 粉体工学会第52回夏期シンポジウム
  • Place of Presentation: 三宮、ひょうご共済会館
  • Year and Date: 2016-08-08
  • Invited
• [Presentation] リポソームエンジニアリング : 高機能化・高性能化への挑戦(受賞講演) (2016)
  • Author(s): 河野 健司
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡、グランシップ
  • Year and Date: 2016-06-30
• [Presentation] CpG-DNAを複合化したpH応答性高分子修飾リポソームの免疫誘導機能 (2016)
  • Author(s): 能崎 優太、弓場 英司、坂口 奈央樹、小岩井 一倫、原田 敦史、河野 健司
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡、グランシップ
  • Year and Date: 2016-06-30
• [Presentation] pH応答性多糖修飾リポソームとTGF-BI型受容体阻害剤包埋リポソームを併用したがん免疫誘導システムの構築 (2016)
  • Author(s): 弓場 英司、上杉慎也、原田 敦史、河野 健司
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡、グランシップ
  • Year and Date: 2016-06-30
• [Presentation] pH応答性膜融合ポリマーとがん細胞膜ベシクルの複合化によるがん抗原デリバリーシステムの構築 (2016)
  • Author(s): 浦﨑拓真、弓場 英司、原田 敦史、河野 健司
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡、グランシップ
  • Year and Date: 2016-06-30
• [Presentation] 血管内皮細胞のクロスプレゼンテーションによるCTLの固形腫瘍への抗原特異的浸潤 (2016)
  • Author(s): 岩出良介、横山水紀、小松利広、木嶋美香、笠井道之、清水健之、佐藤健人、宇高恵子
  • Organizer: 第15回四国免疫フォーラム
  • Place of Presentation: 高知県南国市、高知大学医学部
  • Year and Date: 2016-06-25
• [Presentation] PNIPAM-poly(L-lysine)ブロック共重合体を用いたポリプレックスの形態・機能制御 (2016)
  • Author(s): 勝圓 由希子・野村 健太・弓場 英司・原田 敦史・河野 健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] デンドロン脂質・金ナノロッドハイブリッドベクターの遺伝子導入活性とメカニズム (2016)
  • Author(s): 平田 智哉・弓場 英司・原田 敦史・河野 健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] ポリアミドアミンデンドリマーと金ナノロッドの複合化による多機能性ナノハイブリッドの作製とホトサーマルケモセラピーへの応用 (2016)
  • Author(s): 橋本 拓弥・弓場 英司・原田 敦史・河野健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] T_1O_2 ナノ粒子内包ポリイオンコンプレックスミセルの多価アニオン濃縮効果を利用した細胞内デリバリーと超音波照射効果 (2016)
  • Author(s): 古川 和樹・山本 聡・弓場 英司・原田 敦史・河野 健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] TGF-β受容体阻害剤包埋リポソームの併用によるpH応答性多糖修飾リポソームのがん免疫誘導機能の増強 (2016)
  • Author(s): 弓場 英司・上杉慎也・原田 敦史・河野 健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] 細胞特異性と細胞内デリバリー機能をあわせもつヒアルロン酸誘導体修飾リポソームの構築 (2016)
  • Author(s): 宮﨑麻衣子・弓場 英司・原田 敦史・林弘志・河野 健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] 酸化チタンナノ粒子内包ポリイオンコンプレックスの超音波力学療法効果へのミトコンドリア指向性基導入効果 (2016)
  • Author(s): 森本純平・山本聡・弓場 英司・原田 敦史・河野 健司
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸、国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] Cell-derived vesicles modified with pH-sensitive polymers for intracellular delivery of autologous antigen (2016)
  • Author(s): E. Yuba, T. Sakano, T. Kato, T. Urasaki, A. Harada, K. Kono
  • Organizer: 10^<th> World Biomaterials Congress
  • Place of Presentation: モントリオール、Palais des congres de Montreal
  • Year and Date: 2016-05-17
• [Presentation] Effect of CpG-DNA inclusion in pH-sensitive polymer-liposome vaccines on their immune-inducing activities (2016)
  • Author(s): Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono
  • Organizer: 10^<th> World Biomaterials Congress
  • Place of Presentation: モントリオール、Palais des congres de Montreal
  • Year and Date: 2016-05-17
• [Presentation] Preparation of bollow nanocapsules entrapping cationic sonosensitizer for effective sonodynamic therapy (2016)
  • Author(s): R. Teranishi, E. Yuba, A. Harada, K. Kono
  • Organizer: 10^<th> World Biomaterials Congress
  • Place of Presentation: モントリオール、Palais des congres de Montreal
  • Year and Date: 2016-05-17
• [Presentation] PAMAM dendron-lipid assem-blies stimuli-responsive dug delivery systems. (2015)
  • Author(s): K. Kono, Y. Hirai, Y. Yamamoto, E. Yuba, A. Harada
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Hawaii Convention Center, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Multifunctional liposomes having target-specificity, imaging, and temperature-responsive drug release for cancer chemotherapy. (2015)
  • Author(s): K. Kono, M. Takashima, E. Yuba, A. Harada, D. Kokuryo, I. Aoki, K. Maruyama, S. Aoshima
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Royal Hawaiian, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Design of dendrimer-gold nanohybrids for biomedical applications. (2015)
  • Author(s): K. Kono, T. Hashimoto, X. Li, E. Yuba, A. Harada
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Hawaii Convention Center, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Bioactive polysaccharide-based pH-sensitive polymers for cytoplasmic delivery of antigen and activation of antigen-specific immunity. (2015)
  • Author(s): E. Yuba, A. Yamaguchi, A. Harada, K. Kono
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Sheraton Waikiki, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Development of multifunctional dendrimer-gold nanorod hybrids for photothermal chemotherapy. (2015)
  • Author(s): T. Hashimoto, E. Yuba, A. Harada, K. Kono
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Hawaii Convention Center, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] pH-Sensitive polymer-modified liposomes combined with multiple adjuvants as potent vaccine carriers for cancer immunotherapy. (2015)
  • Author(s): Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Hawaii Convention Center, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Development of pH-sensitive liposomes using hyaluronic acid derivatives for target-specific intracellular drug delivery. (2015)
  • Author(s): M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono
  • Organizer: The International Chemical Congress of PACIFIC BASIN SOCIETIES 2015
  • Place of Presentation: Hawaii Convention Center, Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Functional polymer-liposomes for cancer chemotherapy and immunotherapy. (2015)
  • Author(s): K. Kono
  • Organizer: IUPAC 11th International Conference on Novel Materials and their Synthesis
  • Place of Presentation: Qinhuangdao International Hotel, Qinhuangdao, China
  • Year and Date: 2015-10-11
  • Int'l Joint Research / Invited
• [Presentation] Simultaneous delivery system of antigenic protein and cytokine gene based on pH-sensitive polymer-modified liposomes for induction of antigen-specific immune responses. (2015)
  • Author(s): E. Yuba, Y. Kanda, A. Harada, K. Kono
  • Organizer: The 42nd CRS Annual Meeting & Exposition
  • Place of Presentation: Edinbrgh International Conference Centre, Edinburgh, U.K.
  • Year and Date: 2015-07-26
  • Int'l Joint Research
• [Presentation] Design of multifunctional liposomes having target specificity,temperature-sensitivity and imaging for efficient, personalized chemotherapy. (2015)
  • Author(s): K. Kono, M. Takashima, F. Ozaki, D. Kokuryo, S. Aoshima, K. Maruyama, E.Yuba, A. Harada, Y. Hiramatsu, H. Kitagawa I. Aoki
  • Organizer: The 42nd CRS Annual Meeting & Exposition
  • Place of Presentation: Edinbrgh International Conference Centre, Edinburgh, U.K.
  • Year and Date: 2015-07-26
  • Int'l Joint Research
• [Presentation] Development of multifunctional liposomes for tumor chemotherapy and immunotherapy (2015)
  • Author(s): K. Kono
  • Organizer: ICMAT2015
  • Place of Presentation: SUNTECH, SUNTECH City, Singapore
  • Year and Date: 2015-06-28
  • Int'l Joint Research / Invited
• [Presentation] Development of multifunctional liposomes by surface modification with polymers for cancer therapies. (2015)
  • Author(s): K. Kono
  • Organizer: The 3rd China-Japan Symposium on Nanomedicine
  • Place of Presentation: Institute of Basic Medical Sciences, Beijing, China
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Presentation] Construction of dendrimer-based functional nanohybrids using gold nanoparticles or fllurenes for biomedical applications (2015)
  • Author(s): K. Kono, X. Li, Y. Watanabe, K. Takeda, E. Yuba, A. Harada
  • Organizer: Biomaterials International 2015
  • Place of Presentation: Howard Beach Resort, Kenting, Taiwan
  • Year and Date: 2015-06-01
  • Int'l Joint Research
• [Presentation] Preparation of dual signal-responsive liposomes using methacrylate-based copolymers having oligo (oxyethylene) grafts and their application to drug delivery. (2015)
  • Author(s): T. Sugimoto, N. Yamazaki, E. Yuba, A. Harada, K. Kono
  • Organizer: Biomaterials International 2015
  • Place of Presentation: Howard Beach Resort, Kenting, Taiwan
  • Year and Date: 2015-06-01
  • Int'l Joint Research
• [Presentation] Simultaneous delivery of antigen with pH-sensitive polymer-modified liposomes and cytokine gene with lipoplexes for efficient induction of antitumor immune responses (2014)
  • Author(s): Y. Kanda, E. Yuba, K. Sugiura, N. Sakaguchi, A. Harada, K. Kono
  • Organizer: IPC2014
  • Place of Presentation: つくば国際会議場（茨城県・つくば市）
  • Year and Date: 2014-12-02 – 2014-12-05
• [Presentation] Synthesis of pH-sensitive hyrluronic acid derivatives and their application to anticancer drug delivery (2014)
  • Author(s): M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono
  • Organizer: IPC2014
  • Place of Presentation: つくば国際会議場（茨城県・つくば市）
  • Year and Date: 2014-12-02 – 2014-12-05
• [Presentation] pH応答性デキストラン修飾リポソームのがん免疫誘導能に及ぼす多糖側鎖構造の影響 (2014)
  • Author(s): 上杉慎也、弓場英司、原田敦史、河野健司
  • Organizer: 第36回日本バイオマテリアル学会大会
  • Place of Presentation: タワーホール船堀（東京都・江戸川区）
  • Year and Date: 2014-11-17 – 2014-11-18
• [Presentation] カードラン・マンナン誘導体修飾リポソームを用いるがん免疫誘導：多糖構造の影響 (2014)
  • Author(s): 山口彩加、弓場英司、原田敦史、河野健司
  • Organizer: 第36回日本バイオマテリアル学会大会
  • Place of Presentation: タワーホール船堀（東京都・江戸川区）
  • Year and Date: 2014-11-17 – 2014-11-18
• [Presentation] Dendrimer-Gold Nanoparticle Hybrids for Biomedical Applications (2014)
  • Author(s): K. Kono, X. Li, E. Yuba, A. Harada
  • Organizer: IUPAC 10th International Conference on Novel Materials and their Synthesis
  • Place of Presentation: 鄭州、中国
  • Year and Date: 2014-10-10 – 2014-10-14
  • Invited
• [Presentation] ポリアミドアミンデンドロン脂質を用いた温度・pHデュアル応答性ベシクルのドラッグデリバリー機能 (2014)
  • Author(s): 山本侑平, 弓場英司, 原田敦史, 河野健司
  • Organizer: 第63回高分子討論会
  • Place of Presentation: 長崎大学文京キャンパス（長崎県・長崎市）
  • Year and Date: 2014-09-24 – 2014-09-26
• [Presentation] オリゴオキシエチレングラフト鎖をもつメタクリル酸共重合体を用いる温度・pHデュアル応答性リポソームの作製とドラッグデリバリーへの応用 (2014)
  • Author(s): 杉本卓巳・山﨑奈穂子・弓場英司・原田敦史・河野健司
  • Organizer: 第63回高分子討論会
  • Place of Presentation: 長崎大学文京キャンパス（長崎県・長崎市）
  • Year and Date: 2014-09-24 – 2014-09-26
• [Presentation] スマートナノ分子集合体システムの構築と医療応用 (2014)
  • Author(s): 河野健司
  • Organizer: 第63回高分子討論会
  • Place of Presentation: 長崎大学文京キャンパス（長崎県・長崎市）
  • Year and Date: 2014-09-24 – 2014-09-26
  • Invited
• [Presentation] バイオ機能デンドリマー－金ナノロッドハイブリッドの作製とナノ治療への応用 (2014)
  • Author(s): 河野健司・Xiaojie Li・Phan Thi Thanh Binh・弓場英司・原田敦史
  • Organizer: 第63回高分子討論会
  • Place of Presentation: 長崎大学文京キャンパス（長崎県・長崎市）
  • Year and Date: 2014-09-24 – 2014-09-26
• [Presentation] pH-sensitive polysaccharide derivatives-modified liposomes as antigen delivery vehicles for cancer immunotherapy (2014)
  • Author(s): E. Yuba, S. Uesugi, A. Yamaguchi, A. Harada, K. Kono
  • Organizer: SIPCD2014
  • Place of Presentation: 蘇州、中国
  • Year and Date: 2014-09-16 – 2014-09-19
• [Presentation] Hyaluronic acid derivative-modified liposomes as pH-sensitive anticancer drug delivery system (2014)
  • Author(s): M. Miyazaki, E. Yuba, A. Harada,
  • Organizer: SIPCD2014
  • Place of Presentation: 蘇州、中国
  • Year and Date: 2014-09-16 – 2014-09-19
• [Presentation] Effect of molecular adjuvant inclusion in pH-sensitive polymer-modified liposomes on their performance as antigen delivery carriers for cancer immunotherapy (2014)
  • Author(s): Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono
  • Organizer: SIPCD2014
  • Place of Presentation: 蘇州、中国
  • Year and Date: 2014-09-16 – 2014-09-19
• [Presentation] 非侵襲癌治療を目指した刺激応答ナノキャリアの開発 (2014)
  • Author(s): 河野健司
  • Organizer: 機会学会2014年度年次大会
  • Place of Presentation: 東京電機大学千住キャンパス（東京都・足立区）
  • Year and Date: 2014-09-07 – 2014-09-10
  • Invited
• [Presentation] Design of PAMAM dendron-lipid assemblies with stimuli-responsive properties for drug delivery (2014)
  • Author(s): K. Kono, Y. Hirai, Y. Yamamoto, E. Yuba, A. Harada
  • Organizer: 248th American Chemical Society National Meeting
  • Place of Presentation: San Francisco， ＵＳＡ
  • Year and Date: 2014-08-10 – 2014-08-14
• [Presentation] Polymer-based design of multifunctional liposomes for cancer therapy (2014)
  • Author(s): K. Kono, M. Takashima, Y. Yoshizaki, E. Yuba, A. Harada
  • Organizer: 248th American Chemical Society National Meeting
  • Place of Presentation: San Francisco， ＵＳＡ
  • Year and Date: 2014-08-10 – 2014-08-14
• [Presentation] 標的指向・可視化・高感度温度応答・多重機能型リポソームの作製と腫瘍治療効果 (2014)
  • Author(s): 高嶋宗信, 弓場英司, 原田敦史, 国領大介、青木伊知男、丸山一雄、青島貞人, 河野健司
  • Organizer: 第63回高分子学会年次大会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2014-05-28 – 2014-05-30
• [Presentation] ポリアミドアミンデンドロン脂質を用いた温度・pHデュアル応答ベシクルの作製と細胞との相互作用 (2014)
  • Author(s): 山本 侑平、弓場 英司、 原田 敦史、河野 健司
  • Organizer: 第63回高分子学会年次大会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2014-05-28 – 2014-05-30
• [Presentation] リゴオキシエチレングラフト鎖をもつメタクリル酸共重合体を用いる温度･pHデュアル応答性リポソームの構築 (2014)
  • Author(s): 杉本卓巳・山﨑奈穂子・弓場英司・原田敦史・河野健司
  • Organizer: 第63回高分子学会年次大会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2014-05-28 – 2014-05-30
• [Presentation] Development of dendrimer-gold nanoparticle nanohybrids for biomedical applications (2014)
  • Author(s): K. Kono
  • Organizer: The 2nd Japan-China Symposium on Nanomedicine
  • Place of Presentation: 広島大学東広島キャンパス（広島県・東広島市）
  • Year and Date: 2014-05-16 – 2014-05-17
  • Invited
• [Book] DDSキャリア作製プロトコル集 (2015)
  • Author(s): 河野健司、弓場英司
  • Total Pages: 262
  • Publisher: CMC
• [Remarks] 大阪府立大学大学院工学研究科応用化学分野生体高分子化学研究グループ
  • URL: http://www2.chem.osakafu-u.ac.jp/ohka/ohka9/index.htm
• [Remarks] 大阪府立大学大学院工学研究科応用化学分野生体高分子化学研究グループ
  • URL: http://www.chem.osakafu-u.ac.jp/ohka/ohka9/index.htm
• [Remarks] 大阪府大（工）応用化学生体高分子化学研究室
  • URL: http://www.chem.osakafu-u.ac.jp/ohka/ohka9/index.htm
• [Patent(Industrial Property Rights)] 正電荷脂質と多糖誘導体を含む微粒子担体 (2016)
  • Inventor(s): 弓場英司, 河野健司, 門柚奈, 小岩井一倫, 坂口奈央樹
  • Industrial Property Rights Holder: 公立大学法人大阪府立大学 テルモ株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-214408
  • Filing Date: 2016-11-01