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Observation of micro fluorescence and discrimination of infiltrating brain tumor region using confocal microscope

Research Project

Project/Area Number 26242054
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKanazawa University

Principal Investigator

Yoneyama Takeshi  金沢大学, 機械工学系, 教授 (30175020)

Co-Investigator(Kenkyū-buntansha) 中田 光俊  金沢大学, 医学系, 教授 (20334774)
香川 博之  金沢大学, 機械工学系, 講師 (40251938)
渡辺 哲陽  金沢大学, 機械工学系, 准教授 (80363125)
林 裕  金沢大学, 医学系, 研究員 (90262568)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2016: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2015: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2014: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Keywords脳腫瘍 / 光線力学診断 / 共焦点顕微鏡 / 蛍光 / 光線力学治療 / 医療・福祉 / 人間医工学 / 医用システム / 画像診断
Outline of Final Research Achievements

In photodynamic diagnosis on brain tumor, the fluorescence intensity distribution and average intensity in the tumor observed by confocal microscope are different from those in the normal region. Tumor region is distinguished by the fluorescence intensity distribution.
On the other hand, in the infiltrating region which is difficult to distinguish by fluorescence intensity, the bright spot size and number are different from those in the normal region. Possibility to distinguish infiltration region by the analysis on bright spot size and number observed by confocal microscope has been found.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Fluorescence intensity and bright spot analysis using a confocal microscope for photodynamic diagnosis of brain tumors2017

    • Author(s)
      T.Yoneyama, H.Kagawa, T.Watanabe, Y.Hayashi, M. Nakada
    • Journal Title

      Photodiagnosis and Photodynamic Therapy

      Volume: 17 Pages: 13-21

    • DOI

      10.1016/j.pdpdt.2016.11.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 5-ALA蛍光ガイド下手術における蛍光輝点の分析2016

    • Author(s)
      米山 猛,伊藤雄介1、宮下勝吉2、渡辺哲陽1、中田光俊
    • Organizer
      日本脳神経外科光線力学学会
    • Place of Presentation
      はまぎんホール ヴィアマーレ(横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 5-ALA蛍光ガイド下手術における蛍光微細局在の解析2015

    • Author(s)
      中田光俊、伊藤雄介、片平拓磨、滝沢真、宮下勝吉、渡辺哲陽、米山猛
    • Organizer
      第11回日本脳神経外科光線力学学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膠芽腫浸潤領域判別を目的とした共焦点顕微鏡によるProtoporphyrin IX蛍光強度定量法2014

    • Author(s)
      中田 光俊
    • Organizer
      日本脳神経外科光線力学学会
    • Place of Presentation
      アクトシティ浜松コングレスセンター
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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