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Neurorehabilitation for spinal cord injury to maximize voluntary motor control

Research Project

Project/Area Number 26242056
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Nakazawa Kimitaka  東京大学, 大学院総合文化研究科, 教授 (90360677)

Co-Investigator(Kenkyū-buntansha) 緒方 徹  国立障害者リハビリテーションセンター(研究所), その他部局等, 障害者健康増進・運動医科学支援センター長 (00392192)
西村 幸男  京都大学, 医学研究科, 准教授 (20390693)
河島 則天  国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究室長 (30392195)
柴田 智広  九州工業大学, 大学院生命体工学研究科, 教授 (40359873)
柳原 大  東京大学, 大学院総合文化研究科, 准教授 (90252725)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Keywords脊髄損傷 / 歩行 / ニューロリハビリテーション / 歩行ロボット / ニューロモジュレーション / やる気 / リハビリテーション
Outline of Final Research Achievements

The present study has been performed to obtain scientific bases of a new neuro-rehabilitation system, which can enhance spinal locomotor neural circuits (1), which can maximize participation of the higher nervous system (2), and which can utilize an adaptive locomotion robot that assists patient's stepping motion depnding on his/her locomotor ability. As the results of the study for (1), we succeeded to establish new evaluation methods for spinal motor map and for inducing spinal stretch reflexes from multi-segmental muscles. Regarding (2) we got an idea to use the transcranial direct current stimulation (tDCs) to enhance motivation system in brain, and we have been working on the effects of this method on spinal plasticity. Regarding (3) the initial plan was changed, and a new robotic system that combines neuromodulation technique has been developing.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (35 results)

All 2018 2017 2016 2015 2014

All Journal Article (29 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 29 results,  Open Access: 10 results,  Acknowledgement Compliant: 8 results) Presentation (6 results) (of which Invited: 4 results)

  • [Journal Article] Difference in phase modulation of corticospinal excitability during the observation of the action of walking, with and without motor imagery2018

    • Author(s)
      Kaneko Naotsugu、Masugi Yohei、Yokoyama Hikaru、Nakazawa Kimitaka
    • Journal Title

      NeuroReport

      Volume: 29 Issue: 3 Pages: 169-173

    • DOI

      10.1097/wnr.0000000000000941

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Velocity-dependent transfer of adaptation in human running as revealed by split-belt treadmill adaptation2018

    • Author(s)
      Ogawa Tetsuya、Obata Hiroki、Yokoyama Hikaru、Kawashima Noritaka、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 236 Issue: 4 Pages: 1019-1029

    • DOI

      10.1007/s00221-018-5195-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of the gait adaptation process due to split-belt treadmill walking under a wide range of right-left speed ratios in humans2018

    • Author(s)
      Yokoyama Hikaru、Sato Koji、Ogawa Tetsuya、Yamamoto Shin-Ichiro、Nakazawa Kimitaka、Kawashima Noritaka
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 4 Pages: e0194875-e0194875

    • DOI

      10.1371/journal.pone.0194875

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of motor imagery on spinal reflex excitability of multiple muscles2018

    • Author(s)
      Nakagawa Kento、Masugi Yohei、Saito Akira、Obata Hiroki、Nakazawa Kimitaka
    • Journal Title

      Neuroscience Letters

      Volume: 668 Pages: 55-59

    • DOI

      10.1016/j.neulet.2018.01.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Static magnetic field stimulation applied over the cervical spinal cord can decrease corticospinal excitability in finger muscle2018

    • Author(s)
      Nakagawa K, Nakazawa K
    • Journal Title

      Clin Neurophysiol Pract

      Volume: 3 Pages: 49-53

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Speed dependency in α-motoneuron activity and locomotor modules in human locomotion: indirect evidence for phylogenetically conserved spinal circuits.2017

    • Author(s)
      Hikaru Yokoyama, Tetsuya Ogawa, Masahiro Shinya, Noritaka Kawashima, Kimitaka Nakazawa
    • Journal Title

      Proceedings of the Royal Society B

      Volume: 284 Issue: 1851 Pages: 20170290-20170290

    • DOI

      10.1098/rspb.2017.0290

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle synergies reveal impaired trunk muscle coordination strategies in individuals with thoracic spinal cord injury2017

    • Author(s)
      Milosevic Matija、Yokoyama Hikaru、Grangeon Murielle、Masani Kei、Popovic Milos R.、Nakazawa Kimitaka、Gagnon Dany H.
    • Journal Title

      Journal of Electromyography and Kinesiology

      Volume: 36 Pages: 40-48

    • DOI

      10.1016/j.jelekin.2017.06.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Motor module activation sequence and topography in the spinal cord during air-stepping in human: Insights into the traveling wave in spinal locomotor circuits2017

    • Author(s)
      Yokoyama Hikaru、Hagio Kohtaroh、Ogawa Tetsuya、Nakazawa Kimitaka
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 22

    • DOI

      10.14814/phy2.13504

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Aquatic Pole Walking on the Reduction of Spastic Hypertonia in a Patient with Hemiplegia: A Case Study2017

    • Author(s)
      Obata Hiroki、Ogawa Tetsuya、Hoshino Motonori、Fukusaki Chiho、Masugi Yohei、Kobayashi Hirofumi、Yano Hideo、Nakazawa Kimitaka
    • Journal Title

      International Journal of Physical Medicine & Rehabilitation

      Volume: 05 Issue: 03 Pages: 401-401

    • DOI

      10.4172/2329-9096.1000401

    • NAID

      120006800694

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wheelchair Neuroprosthesis for Improving Dynamic Trunk Stability2017

    • Author(s)
      Patel Kramay、Milosevic Matija、Nakazawa Kimitaka、Popovic Milos R.、Masani Kei
    • Journal Title

      IEEE Transactions on Neural Systems and Rehabilitation Engineering

      Volume: 25 Issue: 12 Pages: 2472-2479

    • DOI

      10.1109/tnsre.2017.2727072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postural regulatory strategies during quiet sitting are affected in individuals with thoracic spinal cord injury2017

    • Author(s)
      Milosevic Matija、Gagnon Dany H.、Gourdou Philippe、Nakazawa Kimitaka
    • Journal Title

      Gait & Posture

      Volume: 58 Pages: 446-452

    • DOI

      10.1016/j.gaitpost.2017.08.032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of anode position on the responses elicited by transcutaneous spinal cord stimulation2017

    • Author(s)
      Masugi Yohei、Obata Hiroki、Nakazawa Kimitaka
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc.

      Volume: 2017 Pages: 1114-1117

    • DOI

      10.1109/embc.2017.8037024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural effects of muscle stretching on the spinal reflexes in multiple lower-limb muscles2017

    • Author(s)
      Masugi Yohei、Obata Hiroki、Inoue Daisuke、Kawashima Noritaka、Nakazawa Kimitaka
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 6 Pages: 275-275

    • DOI

      10.1371/journal.pone.0180275

    • NAID

      120006800693

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Speed dependency in α-motoneuron activity and locomotor modules in human locomotion: indirect evidence for phylogenetically conserved spinal circuits.2017

    • Author(s)
      Yokoyama H, Ogawa T, Kawashima N, Shinya M, Nakazawa K.
    • Journal Title

      Proc Biol Sci

      Volume: 284 Pages: 1851-1851

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinct sets of locomotor modules control the speed and modes of human locomotion.2016

    • Author(s)
      Yokoyama H, Ogawa T, Kawashima N, Shinya M, Nakazawa K.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 36275-36275

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of movement-related afferent inputs on spinal reflexes evoked by transcutaneous spinal cord stimulation during robot-assisted passive stepping.2016

    • Author(s)
      Masugi Y, Kawashima N, Inoue D, Nakazawa K.
    • Journal Title

      Neuroscience Letters.

      Volume: 627 Pages: 100-106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Difference in Postural Control during Quiet Standing between Young Children and Adults: Assessment with Center of Mass Acceleration2015

    • Author(s)
      Oba N, Sasagawa S, Yamamoto A, Nakazawa K.
    • Journal Title

      PLOS ONE

      Volume: 10(10) Issue: 10 Pages: e0140235-e0140235

    • DOI

      10.1371/journal.pone.0140235

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mode-dependent control of human walking and running as revealed by split-belt locomotor adaptation.2015

    • Author(s)
      Ogawa T, Kawashima N, Obata H, Kanosue K, Nakazawa K.
    • Journal Title

      The Journal of Experimental Biology,

      Volume: 218 Pages: 3192-3198

    • DOI

      10.1242/jeb.120865

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term effect of electrical nerve stimulation on spinal reciprocal inhibition during robot-assisted passive stepping in humans.2015

    • Author(s)
      Obata H, Ogawa T, Kitamura, Masugi Y, Takahashi M, Kawashima N, Nakazawa K
    • Journal Title

      European Journal of Neuroscience

      Volume: 42(6) Issue: 6 Pages: 2283-2288

    • DOI

      10.1111/ejn.13000

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinct motor strategies underlying split-belt adaptation in human walking and running.2015

    • Author(s)
      Tetsuya Ogawa, Noritaka Kawashima, Hiroki Obata, Kazuyuki Kanosue, Kimitaka Nakazawa
    • Journal Title

      PLoS ONE

      Volume: 10(3) Issue: 3 Pages: e0121951-e0121951

    • DOI

      10.1371/journal.pone.0121951

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rhythmic arm swing enhances patterned locomotor-like muscle activity in passively moved lower extremities.2015

    • Author(s)
      Tetsuya Ogawa, Takahiko Sato, Toru Ogata, Shin-Ichiro Yamamoto, Kimitaka Nakazawa, Noritaka Kawashima
    • Journal Title

      Physiological Reports

      Volume: 3(3) Issue: 3 Pages: e12317-e12317

    • DOI

      10.14814/phy2.12317

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Velocity-dependent H-reflex suppression of the soleus muscle during robot-assisted passive stepping.2015

    • Author(s)
      Yohei Masugi, Taku Kitamura, Kiyotaka Kamibayashi, Tetsuya Ogawa, Toru Ogata, Noritaka Kawashima, Kimitaka Nakazawa
    • Journal Title

      Neuroscience Letters

      Volume: 584 Pages: 337-341

    • DOI

      10.1016/j.neulet.2014.10.044

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locomotor adaptation: significance and underlying neural mechanisms.2015

    • Author(s)
      Ogawa T, Kawashima N, Nakazawa K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine,

      Volume: 4 Pages: 107-110

    • NAID

      130005130587

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral effect of knee joint motion on body's center of mass during human quiet standing2015

    • Author(s)
      Yamamoto A, Sasagawa S, Oba N, Nakazawa K.
    • Journal Title

      Gait and Posture

      Volume: 41 Issue: 1 Pages: 291-294

    • DOI

      10.1016/j.gaitpost.2014.08.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interpersonal variability in timing strategy and temporal accuracy in rapid interception task with variable time-to-contact.2015

    • Author(s)
      Ijiri T, Shinya M & Nakazawa K.
    • Journal Title

      J Sports Sci.

      Volume: 33 Issue: 4 Pages: 381-390

    • DOI

      10.1080/02640414.2014.946073

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heel strike detection using split force-plate treadmill2015

    • Author(s)
      Rouhani H, Abe MO, Nakazawa K, Popovic MR, Masani K
    • Journal Title

      Gait & Posture

      Volume: 41 Issue: 3 Pages: 863-866

    • DOI

      10.1016/j.gaitpost.2015.02.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neural dynamics in motor preparation: From phase-mediated global computation to amplitude-mediated local computation.2015

    • Author(s)
      Kajihara T, Anwar MN, Kawasaki M, Mizuno Y, Nakazawa K, Kitajo K
    • Journal Title

      Neuroimage,

      Volume: 118 Pages: 445-455

    • DOI

      10.1016/j.neuroimage.2015.05.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical and neural changes in plantar-flexor muscles after spinal cord injury in humans.2015

    • Author(s)
      Yaeshima K, Negishi D, Yamamoto S, Ogata T, Nakazawa K, Kawashima N.
    • Journal Title

      Spinal Cord

      Volume: Feb 10 Issue: 7 Pages: 526-533

    • DOI

      10.1038/sc.2015.9

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 水中ポールウォーキング ―ニューロリハビリテーションへの応用可能性―2015

    • Author(s)
      星野元訓、中澤公孝
    • Journal Title

      バイオメカニクス研究

      Volume: 19 Pages: 34-38

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歩行のニューロリハビリテーション最先端2016

    • Author(s)
      中澤公孝
    • Organizer
      日本作業療法研究学会
    • Place of Presentation
      新潟医療福祉大学(新潟県新潟市)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 歩行ニューロリハビリテーションの最先端2015

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学研究会
    • Place of Presentation
      西鉄イン福岡(福岡県福岡市)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歩行ニューロリハビリテーションの最先端とスポーツの可能性2015

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学研究会
    • Place of Presentation
      東京工科大(東京都大田区)
    • Year and Date
      2015-04-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Locomotor Neurorehabilitation -Past and future direction-2015

    • Author(s)
      中澤公孝
    • Organizer
      International symposium on Hybrid Organs of the future
    • Place of Presentation
      大阪府、吹田市、大阪大学臨床工学研究センター
    • Year and Date
      2015-03-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 歩行ニューロリハビリテーションの最先端とスポーツの可能性 -最新の研究動向から-2014

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学研究会
    • Place of Presentation
      長野県、鹿教湯温泉、鹿教湯リハビリテーション病院
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 歩行ニューロリハビリテーションの可能性 -最新の研究動向から-2014

    • Author(s)
      中澤公孝
    • Organizer
      脳神経科学研究会
    • Place of Presentation
      大阪府、大阪市、大阪保健専門学校
    • Year and Date
      2014-04-19
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2024-07-03  

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