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Clinical application of real-time psycho-behavioral monitoring toward prevention of depression.

Research Project

Project/Area Number 26242069
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionThe University of Tokyo

Principal Investigator

Yamamoto Yoshiharu  東京大学, 大学院教育学研究科(教育学部), 教授 (60251427)

Co-Investigator(Kenkyū-buntansha) 北島 剛司  藤田保健衛生大学, 医学部, 准教授 (40360234)
佐々木 司  東京大学, 教育学研究科(研究院), 教授 (50235256)
森田 賢治  東京大学, 教育学研究科(研究院), 講師 (60446531)
吉内 一浩  東京大学, 医学部附属病院, 准教授 (70313153)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA TORU  大阪大学, 大学院基礎工学研究科, 特任教授 (80419473)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2016: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2015: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2014: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Keywords行動リズム / 気分障害 / 報酬機能
Outline of Final Research Achievements

We developed a real-time monitoring system for behavioral and psychological dynamics in daily life, aiming at prevention of depression. We developed objective and quantitative indicators to evaluate and predict alterations in behavioral and psychological dynamics associated with disease onset / pathological conditions. Furthermore, based on data driven approaches, we reconstructed dynamical structures of psycho-behavioral systems behind the transition phenomena / pathological conditions of behavioral and psychological dynamics, and then found the significant associations of the developed indices with the characteristics of the identified systems. We also gained insight the mechanism that contributes to the early detection of disease onset and pathological state transitions.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 11 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Central Institute of Mental Health/University of Heidelberg(Germany)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Rank among Peers during Game Competition Affects the Tendency to Make Risky Choices in Adolescent Males2017

    • Author(s)
      Jerome C. Foo, Kohei Nagase, Sawako Naramura-Ohno, Kazuhiro Yoshiuchi, Yoshiharu Yamamoto and Kenji Morita
    • Journal Title

      Frontiers in Psychology

      Volume: 8 Pages: 16-16

    • DOI

      10.3389/fpsyg.2017.00016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Momentary Biomarker for Depressive Mood2016

    • Author(s)
      J. Kim, T. Nakamura, Y. Yamamoto
    • Journal Title

      In-Silico Pharmacology

      Volume: 4 Issue: 1 Pages: 1-6

    • DOI

      10.1186/s40203-016-0017-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multiscale Analysis of Intensive Longitudinal Biomedical Signals and Its Clinical Applications2016

    • Author(s)
      T. Nakamura, K. Kiyono, H. Wendt, P. Abry, Y. Yamamoto
    • Journal Title

      Proceedings of the IEEE

      Volume: 104 Issue: 2 Pages: 242-261

    • DOI

      10.1109/jproc.2015.2491979

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Continuous estimation of depressive mood from spontaneous physical activity in major depressive disorder2015

    • Author(s)
      J. Kim, T. Nakamura, H. Kikuchi, K. Yoshiuchi, T. Sasaki, Y. Yamamoto
    • Journal Title

      IEEE J Biomed Health Inform

      Volume: 19 Issue: 4 Pages: 1347-1355

    • DOI

      10.1109/jbhi.2015.2440764

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Co-variation of Depressive Mood and Spontaneous Physical Activity Evaluated by Ecological Momentary Assessment in Major Depressive Disorder2014

    • Author(s)
      J. Kim, T. Nakamura, H Kikuchi, K. Yoshiuchi, Y. Yamamoto
    • Journal Title

      Proc IEEE Eng Med Biol Soc. 2014

      Volume: 36 Pages: 6635-6638

    • DOI

      10.1109/embc.2014.6945149

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 強縦断データを用いた動的疾患研究2016

    • Author(s)
      中村亨
    • Organizer
      第35回 日本医用画像工学会大会
    • Place of Presentation
      千葉県・千葉市
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自発的身体活動の強縦断データによる双極性障害の連続病態把握と病相遷移予測2016

    • Author(s)
      中村亨
    • Organizer
      第55回 日本生体医工学会大会
    • Place of Presentation
      富山県・富山市
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Multiscale analysis for behavioral intermittency and inertia --toward objective and predictive mental health.2016

    • Author(s)
      Yamamoto, Y.
    • Organizer
      Workshop on Mathematical Identification of Momentary Biomarkers, Excellence Initiative of University of Heidelberg
    • Place of Presentation
      Mannheim, Germany
    • Year and Date
      2016-04-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自発的身体活動にみるヒト行動原理とその生成機序の解明2016

    • Author(s)
      中村 亨
    • Organizer
      発達基礎科学研究会
    • Place of Presentation
      同志社びわこリトリートセンター(滋賀県・大津市)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 日常生活行動にみられる行動制御と精神疾患におけるその破綻2015

    • Author(s)
      中村 亨
    • Organizer
      RIMS 研究集会 第 12 回生物数学の理論とその応用
    • Place of Presentation
      京都大学数理解析研究所(京都府・京都市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Multiscale analysis of intensive longitudinal biomedical signals and its clinical applications2015

    • Author(s)
      Y. Yamamoto
    • Organizer
      Gretsi 2015
    • Place of Presentation
      Lyon(France)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 健康情報学の現状と課題 ~予測医療による健康リスク制御に向けて~2015

    • Author(s)
      中村 亨
    • Organizer
      ヘルスケア・医療情報通信技術研究会
    • Place of Presentation
      九州工業大学 飯塚キャンパス(福岡県・飯塚市)
    • Year and Date
      2015-09-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Fatigue and mood assessed with the DRM and EMA2015

    • Author(s)
      Y. Yamamoto
    • Organizer
      Conference on the Day Reconstruction Method (DRM): Review and New Directions
    • Place of Presentation
      University of Southern California (California, USA)
    • Year and Date
      2015-01-08 – 2015-01-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 精神疾患における行動制御系の破綻原理の機序解明に向けて2014

    • Author(s)
      中村 亨
    • Organizer
      第78回 形の科学シンポジウム
    • Place of Presentation
      佐賀大学(佐賀県、佐賀市)2014年11月22日~24日
    • Year and Date
      2014-11-22 – 2014-11-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 連続行動モニタリング情報に基づく精神疾患の早期発見技術の開発2014

    • Author(s)
      中村 亨
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2014
    • Place of Presentation
      金沢大学(石川県、金沢市)
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Health Informatics(健康情報学):日常生活の健康関連行動の連続モニタリングと計測データの利活用2014

    • Author(s)
      中村 亨
    • Organizer
      第37回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Co-variation of Depressive Mood and Spontaneous Physical Activity Evaluated by Ecological Momentary Assessment in Major Depressive Disorder2014

    • Author(s)
      J. Kim
    • Organizer
      The 36rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Sheraton Chicago Hotel and Towers (Chicago, USA)
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大うつ病性障害における自発的身体活動に基づく抑うつ気分の連続評価法の開発2014

    • Author(s)
      金 鎭赫
    • Organizer
      第53回 日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Funded Workshop] The 8th International Workshop on Biosignal Interpretation2016

    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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