| Budget Amount *help |
¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2016: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
In this study, we focused on metabolic or phenotypic changes of cells in tumor microenvironments and searched for marine natural products capable of regulating them. Then, 10 bioactive natural products including 7 novel compounds were discovered. In addition, total synthesis of isolated bioactive natural products, study of structure- activity relationship by synthesized analog compounds, and evaluation of in vivo efficacy were carried out. Furthermore, for the purpose of exploring new drug targets, we analyzed the action-mechanisms and target molecule of bioactive natural products. As a result, the action-mechanism or target molecule of 5 compounds were clarified.
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