Novel imaging mass spectrometry using high energy cluster ions

• Project/Area Number: 26246025
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thin film/Surface and interfacial physical properties
• Research Institution: Kyoto University
• Principal Investigator: Kimura Kenji 京都大学, 工学研究科, 教授 (50127073)
• Co-Investigator(Kenkyū-buntansha): 中嶋 薫 京都大学, 工学(系)研究科(研究院), 准教授 (80293885) ; 鳴海 一雅 国立研究開発法人日本原子力研究開発機構, その他部局等, 研究員 (90354927)
• Co-Investigator(Renkei-kenkyūsha): SAITOH YUICHI 量子科学技術研究開発機構, 量子ビーム科学研究部門, 課長 (40360424)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000); Fiscal Year 2014: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
• Keywords: 2次イオン質量分析 / 分子イメージング / フラーレンイオン / 熱スパイク / フラーレン / 二次イオン質量分析

Outline of Final Research Achievements

We found that the yield of intact biomolecular ions emitted in the forward direction upon transmission of fast ions through a thin film sample is enhanced compared to that emitted in the backward direction. We developed a novel imaging mass spectrometry by combining this transmission secondary ion mass spectrometry with secondary electron microscopy. In this method, secondary electrons emitted in the backward direction are observed using the secondary electron microscope and the secondary ions emitted in the forward direction are mass analyzed simultaneously. It was demonstrated that molecular imaging can be performed with spatial resolution of 1μm using the developed equipment.

Research Products

• [Journal Article] Local heating induced by single MeV C60 ion impacts (2017)
  • Author(s): H. Hayashi, S. Matsuzaki, K. Nakajima, K. Narumi, Y. Saitoh, M. Tsujimoto, M. Toulemonde, and K. Kimura
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 印刷中 Pages: 591-595
  • DOI: 10.1016/j.nimb.2017.01.020
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Temperature of thermal spikes induced by swift heavy ions (2017)
  • Author(s): S. Matsuzaki, H. Hayashi, K. Nakajima, M. Matsuda, M. Sataka, M. Tsujimoto, M. Toulemonde, and K. Kimura
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 印刷中 Pages: 456-459
  • DOI: 10.1016/j.nimb.2016.12.019
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Temperature of thermal spikes in amorphous silicon nitride films produced by 1.11 MeV C603+ impacts (2015)
  • Author(s): T. Kitayama, K. Nakajima, M. Suzuki, K. Narumi, Y. Saitoh, M. Matsuda, M. Sataka, M. Tsujimoto, S. Isoda and K. Kimura
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 354 Pages: 183-186
  • DOI: 10.1016/j.nimb.2014.11.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Formation of ion tracks in amorphous silicon nitride films with MeV C60 ions (2015)
  • Author(s): T. Kitayama, Y. Morita, K. Nakajima, K. Narumi, Y. Saitoh, M. Matsuda, M. Sataka, M. Tsujimoto, S. Isoda, M. Toulemonde, and K. Kimura
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 356-357 Pages: 22-27
  • DOI: 10.1016/j.nimb.2015.07.089
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Tracing temperature in a nanometer size region in a picosecond time period (2015)
  • Author(s): K. Nakajima, T. Kitayama, H. Hayashi, M. Matsuda, M. Sataka, M. Tsujimoto, M. Toulemonde, S. Bouffard, K. Kimura
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 5 Issue: 1 Pages: 13363-13363
  • DOI: 10.1038/srep13363
  • NAID: 120005672545
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Evaluation of local temperature around the impact points of fast ions (2015)
  • Author(s): H. Hayashi, T. Kitayama, S. Matsuzaki, K. Nakajima, K. Narumi, Y. Saitoh, M. Tsujimoto, M. Toulemonde, K. Kimura
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 365 Pages: 569-572
  • DOI: 10.1016/j.nimb.2015.07.042
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 二次電子顕微鏡を用いたSIMSイメージング装置の開発 (2017)
  • Author(s): 中嶋薫, 山本和輝, 石井洋晶, 澤田純平, 木村健二
  • Organizer: 日本物理学会 2017年春季分科会
  • Place of Presentation: 大阪大学（豊中キャンパス）
  • Year and Date: 2017-03-17
• [Presentation] 高速イオンの照射点付近における温度測定V (2017)
  • Author(s): 古株弘樹, 松崎勝太, 李暁星, 中嶋薫, 木村健二, 松田誠, 左高正雄, 鳴海一雅, 斎藤勇一, 辻本将彦
  • Organizer: 日本物理学会 2017年春季分科会
  • Place of Presentation: 大阪大学（豊中キャンパス）
  • Year and Date: 2017-03-17
• [Presentation] Transmission secondary ion mass spectrometry of a peptide using 5 MeV C60 ions (2016)
  • Author(s): K. Nakajima
  • Organizer: International Meeting on Recent Developments in the Study of Radiation Effects in Matter
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-10-27
  • Int'l Joint Research
• [Presentation] Temperature measurement of local heating induced by single MeV C60 ion impact (2016)
  • Author(s): H. Hayashi, S. Matsuzak, K. Nakajima, K. Narumi, Y. Saitoh, M. Matsuda, M. Sataka, M. Tsujimoto, M. Toulemonde, S. Bouffard and K. Kimura
  • Organizer: International Meeting on Recent Developments in the Study of Radiation Effects in Matter
  • Place of Presentation: Kyoto, Lapan
  • Year and Date: 2016-10-27
  • Int'l Joint Research
• [Presentation] 高速イオンを用いた透過型SIMSにおける生体分子の消失断面積 (2016)
  • Author(s): 石井洋晶, 山本和輝, 中嶋薫, 木村健二
  • Organizer: 日本物理学会 2016年秋季大会
  • Place of Presentation: 金沢大学（角間キャンパス）
  • Year and Date: 2016-09-13
• [Presentation] 高速イオンの照射点付近における温度測定IV (2016)
  • Author(s): 中嶋薫, 林宏昭, 松崎勝太, 木村健二, 鳴海一雅, 斎藤勇一, 辻本将彦
  • Organizer: 日本物理学会 2016年秋季大会
  • Place of Presentation: 金沢大学（角間キャンパス）
  • Year and Date: 2016-09-13
• [Presentation] Local heating induced by single MeV C60 ion impact (2016)
  • Author(s): H. Hayashi, S. Matsuzaki, K. Nakajima, K. Narumi, Y. Saitoh, M. Tsujimoto, M. Toulemonde, and K. Kimura
  • Organizer: 27th International Conference on Atomic Collisions in Solids
  • Place of Presentation: Lanzhou, China
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Temperature measurement of thermal spikes produced by swift heavy ions (2016)
  • Author(s): S. Matsuzaki, H. Hayashi, K. Nakajima, M. Matsuda, M. Sataka, M. Tsujimoto, M. Toulemonde, and K. Kimura
  • Organizer: 27th International Conference on Atomic Collisions in Solids
  • Place of Presentation: Lanzhou, China
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Transmission SIMS: A novel approach to achieving higher secondary ion yields of intact biomolecules (2016)
  • Author(s): K. Nakajima, K. Nagano, T. Marumo, K. Yamamoto, K. Narumi, Y. Saitoh, K. Hirata, K. Kimura
  • Organizer: 8th International Workshop on High-Resolution Depth Profiling
  • Place of Presentation: London, Ontario, Canada
  • Year and Date: 2016-07-07
  • Int'l Joint Research / Invited
• [Presentation] 高速C60イオンを用いたペプチドの透過型二次イオン質量分析 (2016)
  • Author(s): 中嶋薫, 丸毛智矢, 山本和輝, 鳴海一雅, 斎藤勇一, 平田浩一, 木村健二
  • Organizer: 日本物理学会 第71回年次大会
  • Place of Presentation: 東北学院大学(宮城県・仙台市）
  • Year and Date: 2016-03-19
• [Presentation] 高速イオンの照射点付近における温度の測定Ⅲ (2016)
  • Author(s): 松崎勝太, 林宏昭, 北山巧, 中嶋薫, 木村健二, 鳴海一雅, 斎藤勇一, 辻本将彦
  • Organizer: 日本物理学会 第71回年次大会
  • Place of Presentation: 東北学院大学(宮城県・仙台市）
  • Year and Date: 2016-03-19
• [Presentation] Transmission secondary ions mass spectrometry of organic molecules using 5 MeV C60+ ions (2015)
  • Author(s): Kaoru Nakajima
  • Organizer: 21st International Workshop on Inelastic Ion-Surface Collisions
  • Place of Presentation: Donostia-San Sebastián, Spain
  • Year and Date: 2015-10-18 – 2015-10-25
  • Invited
• [Presentation] Temperature measurement of thermal spike using desorption of nanoparticles (2015)
  • Author(s): T. Kitayama, H. Hayashi, K. Nakajima, K. Narumi, Y. Saitoh, M. Matsuda, M. Sataka, M. Tsujimoto, M. Toulemonde, S. Bouffard and K. Kimura
  • Organizer: 21th International Workshop on Inelastic Ion Surface collisions
  • Place of Presentation: San Sebastian, Spain
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Transmission secondary ion mass spectroscopy of peptide using 5 MeV C60+ ions (2015)
  • Author(s): T. Marumo, K. Yamamoto, K. Nakajima, K. Narumi, Y. Saitoh, K. Hirata and K. Kimura
  • Organizer: 21th International Workshop on Inelastic Ion Surface collisions
  • Place of Presentation: San Sebastian, Spain
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Transmission Secondary Ion Mass Spectrometry of Organic Molecules using 5 MeV C60+ Ions (2015)
  • Author(s): K. Nakajima
  • Organizer: 21th International Workshop on Inelastic Ion Surface collisions
  • Place of Presentation: San Sebastian, Spain
  • Year and Date: 2015-10-18
  • Int'l Joint Research / Invited
• [Presentation] 高速イオンの照射点付近における温度の測定Ⅱ (2015)
  • Author(s): 林宏昭, 北山巧, 中嶋薫, 松田誠, 左高正雄, 辻本将彦, 木村健二
  • Organizer: 日本物理学会 2015年秋季大会
  • Place of Presentation: 関西大学(大阪府・吹田市）
  • Year and Date: 2015-09-16
• [Presentation] Temperature measurement of thermal spike using desorption of nanoparticles (2015)
  • Author(s): K. Kimura
  • Organizer: 22nd international conference on ion surface interactions
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2015-08-18
  • Int'l Joint Research / Invited
• [Presentation] Transmission SIMS: A novel approach to achieving higher secondary ion yields of intact biomolecules (2015)
  • Author(s): Kenji Kimura
  • Organizer: 17th Scientific International Symposium on SIMS and Related Techniques Based on Ion-Solid Interactions
  • Place of Presentation: 成蹊大学
  • Year and Date: 2015-06-25 – 2015-06-26
  • Invited
• [Presentation] Transmission SIMS: A novel approach to achieving higher secondary ion yields of intact biomolecules (2015)
  • Author(s): K. Kimura
  • Organizer: The 17th Scientific International Symposium on SIMS and Related Techniques Based on Ion-Solid Interactions
  • Place of Presentation: 成蹊大学（東京都・武蔵野市）
  • Year and Date: 2015-06-25
  • Int'l Joint Research / Invited
• [Presentation] Transmission secondary ion mass spectrometry using 5 MeV C60+ ions (2015)
  • Author(s): K. Kimura
  • Organizer: 22nd International Conference on Ion Beam Analysis
  • Place of Presentation: Opatija, Croatia
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Presentation] Synergy effect between electronic and collisional sputtering: The case of amorphous silicon nitride irradiated with energetic C60 ions (2015)
  • Author(s): T. Kitayama, Y. Morita, K. Nakajima, K. Narumi, Y. Saitoh, M. Matsuda, M. Sataka, M. Toulemonde, and K. Kimura
  • Organizer: 9th International Symposium on Swift heavy Ions in Matter
  • Place of Presentation: Darmstadt, Germany
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] Measurement of local temperature around the impact points of fast ions (2015)
  • Author(s): H. Hayashi, T. Kitayama, K. Nakajima, K. Narumi, Y. Saitoh, M. Matsuda, M. Sataka, M. Tsujimoto, M. Toulemonde, K. Kimura
  • Organizer: 9th International Symposium on Swift heavy Ions in Matter
  • Place of Presentation: Darmstadt, Germany
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] 高速C60+イオン透過によるアミノ酸およびペプチドの前方二次イオン放出 (2015)
  • Author(s): 丸毛智矢，中嶋薫，木村健二，鳴海一雅，斎藤勇一
  • Organizer: 日本物理学会 第70回年次大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2015-03-24
• [Presentation] 高速C60+イオン透過によるSiN薄膜上のアミノ酸の前方二次イオン放出II (2014)
  • Author(s): 中嶋薫，丸毛智矢，永野賢悟，木村健二，鳴海一雅，斎藤勇一
  • Organizer: 物理学会2014年秋季大会
  • Place of Presentation: 中部大学
  • Year and Date: 2014-09-17
• [Presentation] Transmission secondary ion mass spectrometry of phenylalanine on silicon nitride membranes using MeV monoatomic and cluster ions (2014)
  • Author(s): Kaoru Nakajima
  • Organizer: 26th International Conference on Atomic Collisions in Solids
  • Place of Presentation: Debrecen, Hungary
  • Year and Date: 2014-07-13 – 2014-07-18
• [Presentation] Transmission secondary ion mass spectrometry of biomolecules using 5 MeV C60+ ions (2014)
  • Author(s): Kenji Kimura
  • Organizer: 7th International Meeting on Recent Developments in the Study ofRadiation Effects in Matter
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-07-09 – 2014-07-12