Non-Equilibrium Dynamics of Cytoskeleton During Cell Migration
| Project/Area Number |
26247070
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Kyoto University |
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Principal Investigator |
Tanaka Motomu 京都大学, 物質－細胞統合システム拠点, 特定拠点教授 (00706814)
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| Co-Investigator(Kenkyū-buntansha) |
見学 美根子 京都大学, 物質-細胞統合システム拠点, 教授 (10303801)
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| Co-Investigator(Renkei-kenkyūsha) |
TSURUYAMA Tatsuaki 京都大学, 医学研究科, 教授 (00303842)
YOSHIKAWA Hiroshi 埼玉大学, 理工学研究科, 助教 (50551173)
HEUSER John 京都大学, 物質-細胞統合システム拠点, 特定拠点教授 (40571815)
YOSHIKAWA Kenichi 同志社大学, 生命医科学部, 教授 (80110823)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000)
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| Keywords | 生命現象の物理 / 形状と運動 / 細胞遊走 / 神経細胞 / 細胞接着 / 細胞骨格 |
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| Outline of Final Research Achievements |
The main thrust of this study is to unravel the correlation between adhesion-induced tension and cytoskeleton dynamics out of equilibrium. Precisely functionalized planar lipid membranes (supported membranes) are used as a quantitative surrogate surface to modulate the coupling between cells and model surfaces. Unique experimental techniques developed in our lab are utilized to unravel the influence of adhesion-induced tension on the active ordering of cytoskeletons and the spatio-temporal patterns in cell migration. The experiments with cells undergoing different modes of deformation and migration, such as neural granule cells and cancerous epithelial cells, enable to gain general principles of non-equilibrium dynamics of cytoskeletons inside self-propelled, crawling cells.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Three-Legged 2,2′-Bipyridine Monomer at the Air/Water Interface: Monolayer Structure and Reactions with Ni(II) Ions from the Subphase2017
Author(s)
Dai, W.; Lee, L.-T.; Schuetz, A.; Zelenay, B.; Zheng, Z.; Borgschulte, A.; Doebeli, M.; Abuillan, W.; Konovalov, O. V.; Tanaka, M.; Schlueter, A. D.
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Journal Title
Langmuir
Volume: 33
Pages: 1646-1654
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency2016
Author(s)
Frank, V.; Kaufmann, S.; Wright, R.; Horn, P.; Yoshikawa, H. Y.; Wuchter, P.; Madsen, J.; Lewis, A. L.; Armes, S. P.; Ho, A. D.; Tanaka. M.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 24264-24264
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress2016
Author(s)
Shatirishvili, M.; Burk, A. S.; Franz, C. M.; Pace, G.; Kastilan, T.; Breuhahn, K.; Hinterseer, E.; Dierich, A.; Bakiri, L.; Wagner, E. F.; Ponta, H.; Hartmann, T. N.; Tanaka, M.; Orian-Rousseau, V.
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Journal Title
Cell Death and Disease
Volume: 7
Issue: 11
Pages: e2461-e2461
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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