Study on microphotonic devices with bidirectional brain communication
Project/Area Number |
26249051
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Electron device/Electronic equipment
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
Ohta Jun 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161)
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Co-Investigator(Kenkyū-buntansha) |
田村 英紀 星薬科大学, 先端生命科学研究所, 特任准教授 (80437516)
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Co-Investigator(Renkei-kenkyūsha) |
TOKUDA Takashi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
SASAGAWA Kiyotaka 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725)
NODA Toshihiko 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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Keywords | イメージセンサ / 埋植デバイス / 蛍光検出 / オプトジェネティクス / 生体内埋植デバイス / 蛍光計測 / 光刺激 / CMOSイメージセンサ / 生体内埋植 / 光遺伝学 / GFP / 脳内埋植 / LED / 蛍光 |
Outline of Final Research Achievements |
We achieved (1) the improvement of performance of implantable devices, (2) bidirectional communication with neural networks, and (3) the establishment of out-body communication method. In high performance of implantable devices, an ultra-thin device with low-induced damage are developed and fabricated. The both functions of imaging and optical stimulation are integrated on a device and demonstrated a bidirectional communication with neural cells. In addition, we achieved optical measurement and stimulation in multiple points. Out-body communication is demonstrated in wireless manner and also demonstrated a method to transmit image data effectively.
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Report
(5 results)
Research Products
(170 results)
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[Journal Article] Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation2017
Author(s)
Makito Haruta,Naoya Kamiyama,Shun Nakajima,Mayumi Motoyama,Mamiko Kawahara Yasumi Ohta,Atsushi Yamasaki,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Yasuyuki Ishikawa,Takashi Tokuda,Hitoshi Hashimoto,Jun Ohta
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Journal Title
Japanese Journal of Applied Physics
Volume: 56
Issue: 5
Pages: 057001-057001
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] "Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca(2+) fluoroimaging".2016
Author(s)
Kobayashi T, Haruta M, Sasagawa K, Matsumata M, Eizumi K, Kitsumoto C, Motoyama M, Maezawa Y, Ohta Y, Noda T, Tokuda T, Ishikawa Y, Ohta J.
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Journal Title
Sci Rep.
Volume: 16
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] "Implantable Imaging Device for Brain Functional Imaging System using Flavoprotein Fluorescence"2016
Author(s)
Yoshinori Sunaga, Hiroshi Yamaura, Makito Haruta, Takahiro Yamaguchi,Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yumiko Yoshimura, and Jun Ohta
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Journal Title
Jpn. J. Appl. Phys.
Volume: 55
Issue: 3S2
Pages: 03DF02-03DF02
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] A packaging method for an implantable brain-machine interface device with a thin film substrate2016
Author(s)
Takahiro Yamaguchi, Yoshinori Sunaga, Makito Haruta, Toshihiko Noda,Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
Organizer
5th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications 2016 (Bio4Apps2016)
Place of Presentation
Griffith University, Queensland, Australia
Year and Date
2016-12-14
Related Report
Int'l Joint Research
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[Presentation] An Implantable Needle Shape Image Sensor with an On-Chip Thinned LED2016
Author(s)
Kiyotaka Sasagawa, Takahiro Yamaguchi, Makito Haruta, Yoshinori Sunaga, Yasumi Ohta, Hironari Takehara, Hiroaki Takehara, Toshihiko Noda, Takashi Tokuda, Jun Ohta
Organizer
2016 International Conference on Solid State Devides and Materials(SSDM2016)
Place of Presentation
Tsukuba International Congress Center, Tsukuba, Ibaraki
Year and Date
2016-09-28
Related Report
Int'l Joint Research
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[Presentation] ここまで進んだ人工の目2016
Author(s)
太田 淳
Organizer
あづみ野ロータリークラブ創立30周年記念講演会
Place of Presentation
豊科交流学習センター,長野県安曇野市
Year and Date
2016-02-27
Related Report
Invited
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[Presentation] Improvement of green fluorescence imaging system based on implantable CMOS imaging device for freely moving mice2015
Author(s)
Yoshinori Sunaga, Hiroshi Yamaura, Makito Haruta, Takahiro Yamaguch1, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yumiko Yoshimura and Jun Ohta
Organizer
Neuroscience 2015 SfN 45th annual meeting
Place of Presentation
McCormick Place Convention Center,Chicago,USA
Year and Date
2015-10-21
Related Report
Int'l Joint Research
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[Presentation] An implantable hemodynamic imaging device for revealing relation between a blood flow and brain activity in animal behavior2015
Author(s)
Makito Haruta,Yoshinori Sunaga,Takahiro Yamaguchi, Hironari Takehara.Yasumi Ohta,Mayumi Motoyama,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Takashi Tokuda,Jun Ohta.
Organizer
Neuroscience 2015 SfN 45th annual meeting
Place of Presentation
McCormick Place Convention Center,Chicago,USA
Year and Date
2015-10-21
Related Report
Int'l Joint Research
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[Presentation] Image processing technique for an implantable image sensor with self-resetting function2015
Author(s)
Kiyotaka Sasagawa, Takahiro Yamaguchi, Makito Haruta, Yoshinori Sunaga, Hironari Takehara, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Takashi Tokuda, Jun Ohta
Organizer
Neuroscience 2015 SfN 45th annual meeting
Place of Presentation
McCormick Place Convention Center,Chicago,USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] Implantable CMOS imaging devices2015
Author(s)
Jun Ohta
Organizer
4th International Symposium on Bioelectronics and Bioinformatics
Place of Presentation
Tsinghua University Rohm Hall, China
Year and Date
2015-10-15
Related Report
Int'l Joint Research / Invited
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[Presentation] An Implantable Hemodynamic Imaging Device for Observing the Process of Recovery from Cerebrovascular Disease2015
Author(s)
Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Yasumi Ohta, Mayumi Motoyama, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
Organizer
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Place of Presentation
MiCo, Milano Conference Center, Italy
Year and Date
2015-08-28
Related Report
Int'l Joint Research
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[Presentation] 動物の脳機能制御を可能にする無線多点光刺激デバイス2015
Author(s)
Makito Haruta, , Naoya Kamiyama, Takahiro Yamaguchi, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
Organizer
第38回日本神経科学大会
Place of Presentation
神戸国際展示場 兵庫県神戸市
Year and Date
2015-07-29
Related Report
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[Presentation] Implantable Imaging Device for Brain Functional Imaging System using Flavoprotein Fluorescence2015
Author(s)
Yoshinori Sunaga, Hiroshi Yamaura, Makito Haruta, Takahiro Yamaguchi, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yumiko Yoshimura and Jun Ohta
Organizer
M&BE8
Place of Presentation
Tower Hall Funabori, Tokyo, Japan
Year and Date
2015-06-22
Related Report
Int'l Joint Research
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[Presentation] 埋め込み型CMOSイメージセンシングデバイス2015
Author(s)
徳田 崇, 竹原 宏明, 野田 俊彦, 笹川 清隆, 太田 淳
Organizer
マルチモーダルバイオイメージセンサ研究会平成26年度第3回研究会
Place of Presentation
ウインク愛知,愛知県名古屋市
Year and Date
2015-03-19
Related Report
Invited
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[Presentation] 自由行動下脳機能計測に向けた緑色蛍光観察用埋植型イメージングデバイス2015
Author(s)
須永 圭紀, 春田 牧人, 山口 貴大, 元山 真由美, 太田 安美, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
Organizer
応用物理学会関西支部 平成26年度第3回講演会「関西発グリーンエレクトロニクス研究の進展」
Place of Presentation
奈良先端科学技術大学院大学,奈良県生駒市
Year and Date
2015-02-27
Related Report
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[Presentation] CMOSバイオイメージセンサ2015
Author(s)
徳田 崇, 竹原 宏明, 野田 俊彦, 笹川 清隆, 太田 淳
Organizer
電子情報通信学会シリコンフォトニクス研究会
Place of Presentation
湯坂温泉 ホテル賀茂川荘, 広島県竹原市
Year and Date
2015-01-22
Related Report
Invited
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[Presentation] An Implantable Green Fluorescence Imaging Device Using Absorption Filters with High Excitation Light Rejection Ratio2014
Author(s)
Yoshinori Sunaga, Makito Haruta, Takahiro Yamaguchi, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
Organizer
IEEE Biomedical Circuits and Systems Conference (BioCAS 2014)
Place of Presentation
SwissTech Convention Center, Lausanne, SWITZERLAND
Year and Date
2014-10-21 – 2014-10-24
Related Report
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[Presentation] Noise Performance of an Implantable Self-reset CMOS Image Sensor2014
Author(s)
Takahiro Yamaguchi, Yoshinori Sunaga, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
Organizer
The 2014 International Meeting for Future of Electron Devices, Kansai (IMFEDK2014)
Place of Presentation
Ryukoku University Avanti Kyoto Hall, Kyoto, JAPAN
Year and Date
2014-06-19 – 2014-06-20
Related Report
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